SEATTLE, WA--(Marketwired - Jul 26, 2017) - CFN Media Group ("CannabisFN"), the leading creative agency and digital media network dedicated to legal cannabis, announces the publication of an article discussing the need for improved delivery technologies for cannabinoid-based therapies and four companies that are on the cutting edge with innovative systems. Cure Pharmaceutical Corp. (
Cannabinoids have demonstrated tremendous potential in treating many medical conditions, ranging from epilepsy to chronic pain. The problem is that many of these conditions rely on cannabinoids passing through the blood-brain barrier, while others require rapid absorption into the bloodstream. Conventional delivery systems are not ideally suited to achieve these goals, which have prompted many companies to develop alternatives.
Oral Thin Films
Listerine® PocketPack® and other breath strips have become a popular way to kill bad breath germs in less than 30 seconds. It turns out that the same type of technology could help efficiently deliver cannabinoids into the bloodstream without the use of water.
CURE Pharmaceutical Corp. (
Since they're simply placed the tongue to dissolve, oral thin films are ideally suited for children and elderly patients that may have trouble swallowing pills. They may also help improve compliance since they don't require water and have improved flavor masking.
GlaxoSmithKline's Nicorette® chewing gum has become the most popular nicotine replacement therapy in the world. But surprisingly, chewing gum hasn't been used as a delivery mechanism for many other drugs despite its convenience and benefits.
AXIM Biotechnologies Inc. (
In addition to effectively delivering cannabinoids into the blood stream, chewing gum offers a controlled release via cellulose and may improve cerebral circulation, stimulate the basal ganglia, reduce stress, improve memory, and offer neuroprotective benefits.
The primary issue with tablets and other swallowed medicine is that they're subject to so-called first pass metabolism. Compounding this problem, studies have shown that cannabinoids do not tolerate acidic environments like the stomach.
Lexaria Corp. (
In addition to improved bioavailability, the company's licensable technology platform has a rapid onset of just 15-20 minutes -- compared to 60-120 minutes for conventional therapies -- along with the elimination of undesirable tastes. The company has already signed several licensing agreements to commercialize the patented technology around the world. Lexaria is working with the Canadian federal government, through the National Research Council, on further research, development, and commercialization opportunities.
Sol-Gel Nasal Delivery
Soft gels have become a popular delivery mechanism since they are easy to administer, familiar to patients, and may contain a variety of different chemicals designed for slow-release and other features that improve the safety and efficacy profile of the active ingredients.
PreveCeutical Medical Inc.'s (
Follow or copy and paste this link to see a video of Dr. Harry Parekh, PreveCeutical's Chief Researcher, explaining the Sol-Gel technology:https://content.jwplatform.com/previews/QRRekyqg-DaoTez7J
The company has pioneered a novel process for preparing insoluble drug-containing nanomicelles and incorporating them into Sol-Gels in conjunction with the Parekh group at PACE-UQ. The team plans to file a provisional patent application around the single phase Sol-Gels for nasal delivery, which could vastly improve bioavailability relative to other therapeutics that are already on the market.
Please follow the link to read the full article: http://www.cannabisfn.com/top-4-companies-reinventing-cannabinoid-delivery/
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