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Wired News – AbbVie Presents New Undetectable Minimal Residual Disease Data from Phase-3 MURANO Trial of Venetoclax with Rituximab at 23rd European Hematology Association Annual Congress

Stock Monitor: NanoViricides Post Earnings Reporting

LONDON, UK / ACCESSWIRE / June 19, 2018 / If you want access to our free research report on AbbVie Inc. (NYSE: ABBV), all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=ABBV as the Company’s latest news hit the wire. On June 15, 2018, the Company announced that it has presented investigational data from a new analysis of undetectable minimal residual disease (uMRD) rates from the pivotal Phase-3 MURANO trial, assessing venetoclax in combination with rituximab (VenR) in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) during the 23rd European Hematology Association (EHA) Annual Congress, Stockholm, held on June 16, 2018. Register today and get access to over 1,000 Free Research Reports by joining our site below:

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83% Patients who Achieved uMRD at End of Combination Therapy with VenR were Progression-Free at 13.8 Months of Follow-Up

The international, multicenter, open-label, randomized Phase-3 MURANO study included a total of 389 patients with R/R CLL who had received at least one prior therapy. The primary endpoint of the study is investigator-assessed progression-free survival, and evaluation of safety of venetoclax in combination with rituximab, in 194 patients of median age 64.5 years, for up to two years; compared to bendamustine in combination with rituximab, in 195 patients of median age 66.0 years, for six months. Of the 121 patients who achieved uMRD (meaning less than one CLL cell in 10,000 white blood cells were detectable using a standardized test) at the end of combination therapy (EOCT), 83% maintained uMRD and were progression-free for a median of 13.8 months thereafter.

Data Supports a Correlation between uMRD and Improved Clinical Outcomes for CLL

Neil Gallagher, M.D., Ph.D., Head of Global Oncology Development at AbbVie, stated that the venetoclax data being presented at EHA adds to the growing body of evidence that supports a correlation between uMRD and improved clinical outcomes for patients with CLL. Gallagher added that the Company continues to investigate the correlation between uMRD and clinical outcomes following treatment with venetoclax alone, or in novel combinations, for the potential treatment of patients with CLL and other blood cancers.

About Chronic Lymphocytic Leukemia (CLL)

CLL is a type of cancer in which the bone marrow makes too many lymphocytes. Early on, there are typically no symptoms. Later non-painful lymph nodes swelling, feeling tired, fever, or weight loss for no clear reason may occur. Enlargement of the spleen and anemia may also occur, which worsens gradually. Risk factors include having a family history of the disease. CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood. These cells do not function well and crowd out healthy blood cells.

About VENCLYXTO® (Venetoclax)

Venetoclax, an oral B-cell lymphoma-2 (BCL-2) inhibitor, is indicated for the treatment of CLL in the presence of 17p deletion or TP53 mutation in adult patients who are unsuitable for or have failed a B-cell receptor pathway inhibitor; and for the treatment of CLL in the absence of 17p deletion or TP53 mutation in adult patients who have failed both chemoimmunotherapy and a B-cell receptor pathway inhibitor. It is also being evaluated for the treatment of patients with various blood cancer types. Venetoclax is being developed by AbbVie and Roche. It is jointly commercialized by AbbVie and Genentech, which is a member of the Roche Group, in the US and by AbbVie outside of the US. Together, the Companies are committed to BCL-2 research with venetoclax, which is currently being evaluated in Phase-3 clinical trials for the treatment of R/R CLL, along with studies in several other cancers.

About AbbVie Inc.

Founded in 2013 and headquartered in North Chicago, Illinois, AbbVie is a global, research and development (R&D) biopharmaceutical organization committed to developing innovative advanced therapies for some of the world’s most complex and critical conditions.

Stock Performance Snapshot

June 18, 2018 - At Monday’s closing bell, AbbVie’s stock declined 1.09%, ending the trading session at $98.48.

Volume traded for the day: 6.43 million shares.

Stock performance in the previous six-month period – up 2.26%; past twelve-month period – up 38.61%; and year-to-date - up 1.83%

After yesterday’s close, AbbVie’s market cap was at $156.68 billion.

Price to Earnings (P/E) ratio was at 15.83.

The stock has a dividend yield of 3.90%.

The stock is part of the Healthcare sector, categorized under the Drug Manufacturers - Major industry.

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