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Wired News – Auris Medical Reported Publication Related to AM-111 in Peer-Reviewed Scientific Journal Hearing Research

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LONDON, UK / ACCESSWIRE / May 08, 2018 / If you want access to our free research report on Auris Medical Holding AG (NASDAQ: EARS), all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=EARS as the Company's latest news hit the wire. On May 04, 2018, the Switzerland-based biopharmaceutical Company announced that the article reviewing the mechanism of action, pharmacokinetics and therapeutic applications of AM-111, the Company's investigational treatment for acute inner ear hearing loss, was published in Hearing Research, one of the leading journals in the otorhinolaryngology field. The peer-reviewed article "Preclinical and clinical otoprotective applications of cell-penetrating peptide D-JNKI-1 (AM-111)" was published. Register today and get access to over 1,000 Free Research Reports by joining our site below:

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Publication Summarizes the Extensive Body of Non-Clinical and Clinical Data on AM-111

Thomas Meyer, Founder, Chairman and Chief Executive Officer of Auris Medical, stated that the publication summarizes the extensive body of non-clinical and clinical data on AM-111 that have been accumulating over more than 15 years of research.

Thomas added that numerous studies have demonstrated AM-111's strong otoprotective effects across various types of acute cochlear injury, ranging from traumatic conditions such as sound overexposure or cochlear implantation to non-traumatic conditions such as acute inflammation, infection, vascular disturbances or ototoxic medications.

Auris Medical Provided Update on AM-111 Development Program

In January 2018, the Company announced clinical results from the HEALOS Phase-3 clinical trial that investigated AM-111 in the treatment of acute inner ear hearing loss and provided an update on the AM-111 development program. While the HEALOS trial had not met the primary efficacy endpoint in the overall study population, post-hoc analyses of top-line data revealed a clinically and statistically significant hearing improvement with AM-111 from baseline to Day 28 in the subpopulation of patients with profound hearing loss (n=98). AM-111 was well tolerated and the primary safety endpoint was met. The results from the profound acute hearing loss subgroup in HEALOS were broadly in-line with those observed in the same subpopulation in the prior Phase-2 clinical trial with AM-111.

About AM-111

AM-111 is being developed in a biocompatible gel formulation for the treatment of acute sensorineural hearing loss with a single-dose administration into the middle ear. Its active substance is brimapitide (also known as D-JNKI-1, D-stereoisomer of c-Jun N-terminal Kinase Inhibitor 1), a cell-penetrating peptide which inhibits the JNK stress kinase. JNK is activated following various types of cochlear insults (stress) that cause acute inner ear hearing loss and plays a key role in apoptosis of sensory cells as well as in inflammatory responses. AM-111 has orphan drug designation from both the US Food and Drug Administration and the European Medicines Agency.

About Auris Medical Holding AG

Founded in 2003 and headquartered in Basel, Switzerland, Auris Medical is a biopharmaceutical company dedicated to developing therapeutics that address important unmet medical needs in neurotology. The Company has two Phase-3 programs: AM-111 (brimapitide otic gel) for the treatment of acute inner ear hearing loss and Keyzilen® (AM-101; esketamine otic gel) for the treatment of acute inner ear tinnitus.

Stock Performance Snapshot

May 07, 2018 - At Monday's closing bell, Auris Medical's stock advanced 9.39%, ending the trading session at $1.98.

Volume traded for the day: 2.65 million shares, which was above the 3-month average volume of 392.29 thousand shares.

Stock performance in the last month – up 41.43%

After yesterday's close, Auris Medical's market cap was at $9.96 million.

The stock is part of the Healthcare sector, categorized under the Biotechnology industry. This sector was up 0.2% at the end of the session.

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