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LONDON, UK / ACCESSWIRE / April 23, 2018 / Active-Investors.com has just released a free research report on Capricor Therapeutics, Inc. (NASDAQ: CAPR) ("Capricor"). If you want access to this report all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=CAPR as the Company's latest news hit the wire. On April 19, 2018, the Company announced that its pre-clinical study has established that repeated dosing of its lead candidate, CAP-1002, yields an increase in exercise performance in a disease model of Duchenne Muscular Dystrophy (DMD), the mdx mouse. Register today and get access to over 1000 Free Research Reports by joining our site below:
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Repeat Dosing of CAP-1002 Resulted in Improvements in Absolute Force in Soleus and Diaphragm of a Mouse Model of DMD
Researchers reported that while CAP-1002 is recognized by the immune system, its low immunogenic profile and immunomodulatory capabilities allowed it to be administered multiple times without significant safety issues. It was also reported that repeat dosing was shown to sustain the effect of the therapeutic. The research found improvements in absolute force in soleus (leg) and in the diaphragm of a mouse model of DMD, the mdx mouse. Additionally, decreased fibrosis in skeletal and cardiac muscles after three administrations of CAP-1002 was observed.
Findings were Foundation for Design of HOPE-2 Clinical Trial
These findings were the foundation for the design of the HOPE-2 clinical trial that Capricor will initiate shortly. The HOPE-2 clinical trial will test the safety and efficacy of repeat doses of CAP-1002 in boys and young men with DMD. Up to 84 boys and young men with DMD will be enrolled in the Phase-2, randomized, double-blind, placebo-controlled trial. HOPE-2 will test repeat doses of CAP-1002 in participants with advanced stages of DMD.
CAP-1002 has Potential to Work Synergistically with Gene Therapies for DMD
Linda Marbán, Ph.D., President and Chief Executive Officer (CEO) at Capricor, stated that the Company is eager to get the HOPE-2 trial underway as it may potentially be a registration trial, and also because the potential for improvements in muscle function in both pre-clinical studies and in the Company's earlier HOPE-Duchenne clinical trial was observed. Marbán added that CAP-1002 also has the potential to work synergistically with gene and other therapies for DMD.
Capricor Received FDA's Regenerative Medicine Advanced Therapy Designation for DMD Therapy
On February 05, 2018, the US Food and Drug Administration (FDA) granted the candidate CAP-1002 with a Regenerative Medicine Advanced Therapy (RMAT) designation for DMD Therapy. To receive the RMAT designation, Capricor submitted data from an earlier trial, the HOPE-Duchenne Trial, which reported significant and sustained improvements in skeletal muscle function and cardiac structure in boys and young men in advanced stages of DMD, following a single dose of intracoronary CAP-1002.
The FDA granted Rare Pediatric Disease Designation and Orphan Drug Designation to CAP-1002 in August 2015 and July 2017, respectively.
About Duchenne Muscular Dystrophy (DMD)
DMD is a genetic disorder characterized by progressive muscle degeneration and weakness. It is one of nine types of muscular dystrophy. DMD is caused by an absence of dystrophin, a protein that helps keep muscle cells intact. Symptom onset is in early childhood, usually between the ages of 3 and 5. The disease primarily affects boys, but in rare cases can also affect girls.
CAP-1002 consists of allogeneic cardiosphere-derived cells (CDCs), a unique population of cells that contains cardiac progenitor cells. CAP-1002 has been shown to exert potent immunomodulatory activity and stimulate cellular regeneration. CDCs have been the subject of over 100 peer-reviewed scientific publications and have been administered to approximately 140 human subjects across several clinical trials.
About Capricor Therapeutics, Inc.
Founded in 2005 and headquartered in Beverly Hills, California, Capricor is a clinical-stage biotechnology organization focused on the discovery, development, and commercialization of first-in-class biological therapeutics for the treatment of rare disorders.
Stock Performance Snapshot
April 20, 2018 - At Friday's closing bell, Capricor Therapeutics' stock dropped 6.16%, ending the trading session at $1.37.
Volume traded for the day: 317.68 thousand shares.
After last Friday's close, Capricor Therapeutics' market cap was at $39.40 million.
The stock is part of the Healthcare sector, categorized under the Biotechnology industry.
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