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Wired News – Compugen Reports Publication of Discovery and Validation of ILDR2 as A Novel Immune Checkpoint and Its Use for Auto-Immune Diseases

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LONDON, UK / ACCESSWIRE / February 08, 2018 / Active-Investors.com has just released a free research report on Compugen Ltd (NASDAQ: CGEN). If you want access to this report all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=CGEN as the Company's latest news hit the wire. On February 06, 2018, the Company, a therapeutic discovery firm, announced the online publication of the data pertaining to the discovery and validation of the ILDR2 protein as a novel immune checkpoint and its use as an Fc fusion protein for the treatment of auto-immune diseases in two peer-reviewed papers in The Journal of Immunology. Antibody-based therapeutics targeting ILDR2 (CGEN-15001T) for immuno-oncology were licensed to Bayer AG, while Compugen retains the full rights to the fusion protein CGEN-15001. Register today and get access to over 1000 Free Research Reports by joining our site below:


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Compugen, First to Publish Data on ILDR2 as a New Immune Checkpoint with a Therapeutic Role in Auto-Immune Diseases

Anat Cohen-Dayag, PhD, President and Chief Executive Officer (CEO) of Compugen, mentioned that Compugen is the first to publish data on ILDR2 as a new immune checkpoint with a potential therapeutic role in auto-immune diseases and cancer immuno-therapy, each presenting first-in-class therapeutic opportunities. This is the third novel immune checkpoint disclosed by the Company, following PVRIG and TIGIT. Cohen-Dayag added that Compugen has identified a new pathway with robust and diversified data supporting ILDR2 mechanism-of-action and broad therapeutic potential, both for the treatment of auto-immune diseases and for cancer immuno-therapy.

Publications Supporting Immune-Related Functions of ILDR2 and Its Use in Auto-Immune Diseases

  • ILDR2, a Novel B7-like Protein that Negatively Regulates T Cell Responses - The publication describes the computational discovery approach leading to the discovery of ILDR2 as a novel immune checkpoint. The experimental validation of the role of this protein as a negative regulator of T cell activity was established. The publication reports the beneficial effects of CGEN-15001 in an animal model of rheumatoid arthritis (RA), as well as in a translational assay utilizing blood cells from RA patients that mimics the deleterious interactions of immune cells in the RA synovium. These findings assign a new role to the ILDR2 protein, whose immune-related function was not previously known.
  • ILDR2-Fc, a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance - In a pre-clinical research, an additional paper was published demonstrating the potential of ILDR2-Fc fusion protein to address auto-immune and inflammatory conditions, as well as the mechanism of action underlying this activity. The data showed the potent and long-lasting immuno-modulatory activity of ILDR2-Fc fusion protein in animal models of multiple sclerosis (R-EAE) and type 1 diabetes, and its ability to promote engraftment in an animal model of bone marrow transplantation. These findings point to a compelling mode of action for this Fc fusion protein in auto-immune diseases.

CGEN-15001 Demonstrated Restoration of Immune Tolerance in Auto-Immunity

In January 2017, the Company disclosed new animal model results demonstrating the restoration of immune tolerance by CGEN-15001. The immune tolerance established by CGEN-15001 was shown to be antigen-specific, indicating that treatment with CGEN-15001 has the potential to not only generate a durable response, but also to avoid the global immune suppression generated by other therapeutic agents for auto-immune diseases.

Compugen Collaboration with Bayer in Immuno-Oncology

In July 2017, Compugen announced updates to its collaborative activities in immuno-oncology with Bayer. The agreement with Bayer involves the research, development, and commercialization of antibody-based therapeutics against novel immune checkpoint regulator, CGEN-15001T. As announced in August 2013, the CGEN-15001T program continues to be advanced by Bayer towards human clinical trials, for which pre-clinical stage milestones have been achieved.

About Auto-Immune Diseases

An auto-immune disease is a condition in which one's immune system mistakenly attacks one's body. There are at least 80 types of auto-immune diseases. Nearly any body part can be involved. The common symptoms include low grade fever and tiredness. Often symptoms come and go. Some auto-immune diseases, such as lupus, run in families, and certain cases may be triggered by infections or other environmental factors.

About CGEN-15001

CGEN-15001, Compugen's lead program, is an Fc fusion protein consisting of the extracellular domain of ILDR2 and an Fc domain, for the potential use in auto-immune diseases. It is a first-in-class therapeutic candidate of a novel inhibitory checkpoint pathway, with the potential to restore immune tolerance and re-establish immune homeostasis, thus potentially offering patients a durable therapeutic response and a safer treatment profile.

About Compugen Ltd

Founded in 1993 and headquartered in Holon, Israel, Compugen is a drug discovery Company with a unique, broadly applicable, predictive discovery infrastructure, which is advancing a therapeutic pipeline consisting mainly of early-stage immuno-oncology programs, aimed at harnessing the immune system to eradicate cancer in the United States, Europe, and Israel.

Stock Performance Snapshot

February 07, 2018 - At Wednesday's closing bell, Compugen's stock slightly rose 0.94%, ending the trading session at $2.67.

Volume traded for the day: 183.28 thousand shares.

Stock performance in the last month – up 4.90%; and year-to-date - up 7.00%

After yesterday's close, Compugen's market cap was at $139.80 million.

The stock is part of the Healthcare sector, categorized under the Biotechnology industry.


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