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Wired News – Pluristem’s PLX Cells Demonstrated Inhibition of Cancer Cell Growth in Peer-Reviewed Article

Stock Monitor: CEL-SCI Post Earnings Reporting

LONDON, UK / ACCESSWIRE / January 17, 2018 / Active-Investors.com has just released a free research report on Pluristem Therapeutics Inc. (NASDAQ: PSTI). If you want access to this report all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=PSTI as the Company's latest news hit the wire. On January 12, 2018, the Company announced that it has published a peer-reviewed article in the journal Scientific Reports, titled, "Human Placental-Derived Adherent Stromal Cells Co-Induced with TNF‑α and IFN‑γ Inhibit Triple-Negative Breast Cancer in Nude Mouse Xenograft Models". The article published is based on studies that examined the effect of PLX cells that had been induced with tumor necrosis factor alpha (TNF-α) and interferon-gamma (IFN-γ), on the proliferation of over 50 lines of human cancerous cells. Register today and get access to over 1000 Free Research Reports by joining our site below:

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Modified PLX Cells Exhibited Anti-Proliferative Effect on 45% of the Tested Cancer Cell Lines

It was found from the first study that the modified PLX cells exhibited an anti-proliferative effect on 45% of the tested cancer cell lines, with a strong inhibitory effect on various lines of breast, colorectal, kidney, liver, lung, muscle and skin cancers. Common characteristics of the cancer cell lines that were inhibited by PLX cells were identified using comprehensive bioinformatics analysis. This information can be used in the future for screening patients' tumors to identify those patients most likely to show a positive response to the treatment.

Pre-Clinical Study Results Revealed Statistically Significant Reduction in Tumor Size

On the basis of these results, the Company then conducted a pre-clinical study of female mice harboring human triple negative breast cancer (TNBC). In this study, female mice were injected with weekly intramuscular (IM) injections induced with PLX cells. The treatment produced a statistically significant reduction in mean tumor size in the treated group compared with the untreated group, with 30% of the treated mice exhibiting complete tumor remission. Additionally, statistically significant reduction in the percentage of proliferating tumor cells as well as in the level of blood vessels within the tumors was observed.

Findings Demonstrate Utilization of Pluristem's Induced PLX Cells in Reversing Cancer Cells Growth

Zami Aberman, Chairman and Co-CEO of Pluristem, mentioned that the findings of the study published demonstrate the utilization of Pluristem's induced PLX cells in slowing and reversing the growth of cancer cells, particularly for some cancers that don't have viable treatment options. The findings also confirm the effectiveness of IM administration and support a mechanism of action involving immunomodulation and inhibition of angiogenesis and cell proliferation in cancerous conditions. Zami added that the company's unique patented manufacturing platform allows it to alter its cells' secretion profile in correlation with the targeted cancer cells, which may open new possibilities in the field of oncology to treat solid tumors.

About PLX Cells

Pluristem's PLacental eXpanded (PLX) cells are placenta-derived, mesenchymal-like adherent stromal cells that are designed to be administered to patients without the need for tissue or genetic matching. These cells release soluble biomolecules which act in a paracrine or endocrine manner to facilitate healing of damaged tissue by stimulating the body's own regenerative mechanisms. The Company has filed patent applications relating to the technology for the induction of PLX cells and the use of these cells for the treatment of cancer.

About Triple Negative Breast Cancer (TNBC)

TNBC is an aggressive form of breast cancer that does not respond to standard hormonal therapy due to a lack of estrogen and progesterone receptors. This makes it more difficult to treat since most hormone therapies target one of the three receptors, so triple-negative cancers often require combination therapies. TNBC have a relapse pattern that is very different from hormone-positive breast cancers, the risk of relapse is much higher for the first 3–5 years but drops sharply and substantially below that of hormone-positive breast cancers.

About Pluristem Therapeutics Inc.

Founded in 2003, Pluristem Therapeutics is a clinical-stage biotherapy company using placental cells and a unique, proprietary, three-dimensional (3D) technology platform to develop cell therapies for conditions such as inflammation, ischemia, hematological disorders, or exposure to radiation. The Company is headquartered in Haifa, Israel.

Stock Performance Snapshot

January 16, 2018 - At Tuesday's closing bell, Pluristem Therapeutics' stock declined 1.24%, ending the trading session at $1.59.

Volume traded for the day: 648.61 thousand shares, which was above the 3-month average volume of 480.80 thousand shares.

Stock performance in the last month – up 14.80%; previous six-month period – up 33.61%; past twelve-month period – up 1.92%; and year-to-date - up 15.22%

After yesterday's close, Pluristem Therapeutics' market cap was at $170.70 million.

The stock is part of the Healthcare sector, categorized under the Biotechnology industry. This sector was flat at the end of the session.

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