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Wired News - Reata Pharma Presented Encouraging Interim Data from PHOENIX Trial Assessing Bardoxolone Methyl in Patients with ADPKD and IgA Nephropathy

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LONDON, UK / ACCESSWIRE / May 30, 2018 / If you want access to our free research report on Reata Pharmaceuticals, Inc. (NASDAQ: RETA), all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=RETA as the Company's latest news hit the wire. On May 25, 2018, the Company announced that it has presented results from the ongoing, open-label, Phase-2 PHOENIX trial assessing bardoxolone methyl (bardoxolone) in patients with autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy cohorts at the European Renal Association and European Dialysis and Transplant Association (ERA-EDTA) meeting in Copenhagen. Register today and get access to over 1,000 Free Research Reports by joining our site below:


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Primary Endpoint of PHOENIX Study is Change from Baseline in eGFR after 12 Weeks of Treatment

The Phase-2 PHOENIX program is studying bardoxolone in patients with ADPKD, IgA nephropathy, focal segmental glomerulosclerosis, and chronic kidney disease (CKD) associated with type-1 diabetes. The primary efficacy endpoint of the study is change from baseline in eGFR after 12 weeks of treatment. The ADPKD cohort of PHOENIX enrolled 31 patients, and available data demonstrate that bardoxolone significantly improved kidney function in ADPKD patients as measured by their estimated glomerular filtration rate (eGFR). Bardoxolone-treated patients showed a mean improvement of 6.6 mL/min/1.73 m2 at Week 4, increasing to 12.0 mL/min/1.73 m2 at Week 12. The IgA nephropathy cohort enrolled 26 patients, and data were reported through Week 8. Bardoxolone-treated patients showed a mean improvement of 8.4 mL/min/1.73 m2 at Week 8 from a mean baseline eGFR of 46.2 mL/min/1.73 m2. No drug-related serious adverse events have been reported.

Full data for the primary endpoint of change in eGFR at Week 12 for the ADPKD, IgA nephropathy, and type-1 diabetic CKD cohorts of PHOENIX will be available in Q3 2018.

Bardoxolone May Delay Onset of Kidney Failure in Patients with Type-2 Diabetes & Stage 4 CKD

An oral presentation entitled ''Bardoxolone Methyl Prevents eGFR Decline in Patients with Chronic Kidney Disease Stage 4 and Type-2 Diabetes - Post-hoc Analyses from BEACON'' was also given. The analysis demonstrated that patients randomized to bardoxolone were more than 50% less likely than patients receiving placebo to experience events that predict kidney failure. The authors of the abstract concluded that bardoxolone preserves kidney function and may delay the onset of kidney failure in patients with type-2 diabetes and stage 4 CKD. The abstract was named a Ten Best Abstract by the Paper Selection Committee of ERA-EDTA.

About Bardoxolone Methyl

Bardoxolone is an experimental, oral, once-daily activator of Nrf2, a transcription factor that induces molecular pathways that promote the resolution of inflammation by restoring mitochondrial function, reducing oxidative stress, and inhibiting pro-inflammatory signaling. The FDA has granted orphan designation to bardoxolone for the treatment of Alport syndrome and for the treatment of connective tissue disease associated pulmonary arterial hypertension.

About Autosomal Dominant Polycystic Kidney Disease and IgA Nephropathy

ADPKD is a genetic form of CKD caused by mutations in PKD1 and PKD2 genes leading to inflammation that stimulates the formation of fluid-filled cysts in the kidneys that cause pain and progressive loss of kidney function.

IgA nephropathy, also known as Berger's disease, is a rare form of CKD that occurs when IgA deposits build up in the kidneys, causing inflammation that damages kidney tissues. There are currently no FDA-approved therapies for IgA nephropathy.

About Reata Pharmaceuticals, Inc.

Founded in 2002 and headquartered in Irving, Texas, Reata Pharma is a clinical-stage biopharmaceutical company that develops novel therapeutics for patients with serious or life-threatening diseases by targeting molecular pathways involved in the regulation of cellular metabolism and inflammation.

Stock Performance Snapshot

May 29, 2018 - At Tuesday's closing bell, Reata Pharma's stock rose 1.73%, ending the trading session at $34.19.

Volume traded for the day: 145.36 thousand shares.

Stock performance in the last month - up 30.50%; previous three-month period - up 36.71%; past twelve-month period - up 26.63%; and year-to-date - up 20.73%

After yesterday's close, Reata Pharma's market cap was at $904.67 million.

The stock is part of the Healthcare sector, categorized under the Biotechnology industry.


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