| 0.30% | % of Shares Held by All Insider |
| 98.72% | % of Shares Held by Institutions |
| 99.01% | % of Float Held by Institutions |
| 274 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Baker Brothers Advisors, LLC | 39,713,842 | Mar 30, 2019 | 27.55% | 1,066,316,657 |
| FMR, LLC | 21,582,357 | Mar 30, 2019 | 14.97% | 579,486,285 |
| Blackrock Inc. | 10,718,708 | Mar 30, 2019 | 7.43% | 287,797,309 |
| Vanguard Group, Inc. (The) | 9,497,642 | Mar 30, 2019 | 6.59% | 255,011,687 |
| Price (T.Rowe) Associates Inc | 7,357,656 | Mar 30, 2019 | 5.10% | 197,553,063 |
| State Street Corporation | 4,865,697 | Mar 30, 2019 | 3.38% | 130,643,964 |
| First Trust Advisors LP | 4,815,776 | Mar 30, 2019 | 3.34% | 129,303,585 |
| Oppenheimer Funds, Inc. | 3,644,406 | Mar 30, 2019 | 2.53% | 97,852,301 |
| Great Point Partners LLC | 2,000,000 | Mar 30, 2019 | 1.39% | 53,700,000 |
| Goldman Sachs Group, Inc. | 1,933,145 | Mar 30, 2019 | 1.34% | 51,904,943 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Growth Company Fund | 7,197,067 | Apr 29, 2019 | 4.99% | 173,089,461 |
| First Trust NYSE Arca Biotechnology Index Fund | 5,870,693 | Sep 29, 2018 | 4.07% | 121,875,586 |
| Vanguard Total Stock Market Index Fund | 3,006,124 | Dec 30, 2018 | 2.09% | 48,609,025 |
| Vanguard Small-Cap Index Fund | 2,910,441 | Dec 30, 2018 | 2.02% | 47,061,830 |
| Fidelity Select Portfolios - Biotechnology | 2,882,880 | Apr 29, 2019 | 2.00% | 69,333,264 |
| Price (T.Rowe) Health Sciences Fund | 2,606,130 | Mar 30, 2019 | 1.81% | 69,974,590 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 2,604,252 | Apr 29, 2019 | 1.81% | 62,632,260 |
| Price (T.Rowe) New Horizons Fund | 2,532,116 | Mar 30, 2019 | 1.76% | 67,987,314 |
| iShares Russell 2000 ETF | 2,331,643 | Apr 29, 2019 | 1.62% | 56,076,014 |
| Fidelity Series Growth Company Fund | 2,142,887 | Apr 29, 2019 | 1.49% | 51,536,432 |