| 0.30% | % of Shares Held by All Insider |
| 98.72% | % of Shares Held by Institutions |
| 99.01% | % of Float Held by Institutions |
| 274 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Baker Brothers Advisors, LLC | 39,713,842 | Dec 30, 2018 | 31.75% | 642,172,825 |
| FMR, LLC | 21,543,893 | Dec 30, 2018 | 17.22% | 348,364,749 |
| Vanguard Group, Inc. (The) | 10,141,664 | Dec 30, 2018 | 8.11% | 163,990,706 |
| Blackrock Inc. | 10,133,466 | Dec 30, 2018 | 8.10% | 163,858,145 |
| Price (T.Rowe) Associates Inc | 6,856,137 | Dec 30, 2018 | 5.48% | 110,863,735 |
| State Street Corporation | 4,839,186 | Dec 30, 2018 | 3.87% | 78,249,637 |
| First Trust Advisors LP | 4,138,725 | Dec 30, 2018 | 3.31% | 66,923,183 |
| Oppenheimer Funds, Inc. | 3,628,576 | Dec 30, 2018 | 2.90% | 58,674,073 |
| Janus Henderson Group PLC | 3,142,042 | Dec 30, 2018 | 2.51% | 50,806,819 |
| Citadel Advisors LLC | 2,838,922 | Dec 30, 2018 | 2.27% | 45,905,368 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Growth Company Fund | 7,173,764 | Feb 27, 2019 | 5.74% | 190,104,746 |
| First Trust NYSE Arca Biotechnology Index Fund | 5,870,693 | Sep 29, 2018 | 4.69% | 121,875,586 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 2,953,470 | Feb 27, 2019 | 2.36% | 78,266,955 |
| Fidelity Select Portfolios - Biotechnology | 2,882,880 | Feb 27, 2019 | 2.30% | 76,396,320 |
| Vanguard Small-Cap Index Fund | 2,553,390 | Sep 29, 2018 | 2.04% | 53,008,376 |
| Vanguard Total Stock Market Index Fund | 2,531,407 | Sep 29, 2018 | 2.02% | 52,552,009 |
| Janus Henderson Enterprise Fund | 2,501,075 | Dec 30, 2018 | 2.00% | 40,442,382 |
| Price (T.Rowe) Health Sciences Fund | 2,408,330 | Dec 30, 2018 | 1.93% | 38,942,696 |
| Fidelity Series Growth Company Fund | 2,121,687 | Feb 27, 2019 | 1.70% | 56,224,705 |
| iShares Russell 2000 ETF | 2,065,189 | Feb 27, 2019 | 1.65% | 54,727,508 |