| 5.20% | % of Shares Held by All Insider |
| 101.40% | % of Shares Held by Institutions |
| 106.96% | % of Float Held by Institutions |
| 194 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Wellington Management Company, LLP | 10,159,082 | Mar 30, 2019 | 12.17% | 138,671,469 |
| Price (T.Rowe) Associates Inc | 9,105,567 | Mar 30, 2019 | 10.90% | 124,290,989 |
| Redmile Group, LLC | 8,244,896 | Mar 30, 2019 | 9.87% | 112,542,830 |
| Vanguard Group, Inc. (The) | 6,549,249 | Mar 30, 2019 | 7.84% | 89,397,248 |
| Blackrock Inc. | 5,774,520 | Mar 30, 2019 | 6.92% | 78,822,198 |
| Goldman Sachs Group, Inc. | 3,289,275 | Mar 30, 2019 | 3.94% | 44,898,603 |
| Samlyn Capital, LLC | 3,185,983 | Mar 30, 2019 | 3.82% | 43,488,667 |
| State Street Corporation | 3,165,522 | Mar 30, 2019 | 3.79% | 43,209,375 |
| Citadel Advisors LLC | 3,096,897 | Mar 30, 2019 | 3.71% | 42,272,644 |
| Foresite Capital Management III, LLC | 2,942,130 | Mar 30, 2019 | 3.52% | 40,160,074 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Price (T.Rowe) Health Sciences Fund | 2,582,937 | Mar 30, 2019 | 3.09% | 35,257,090 |
| Price (T.Rowe) New Horizons Fund | 2,035,875 | Mar 30, 2019 | 2.44% | 27,789,693 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 2,003,773 | Apr 29, 2019 | 2.40% | 27,231,275 |
| Price (T.Rowe) Small Cap Stock Fund | 1,739,578 | Mar 30, 2019 | 2.08% | 23,745,239 |
| Vanguard Total Stock Market Index Fund | 1,501,172 | Dec 30, 2018 | 1.80% | 15,387,013 |
| Vanguard Small-Cap Index Fund | 1,498,810 | Dec 30, 2018 | 1.79% | 15,362,802 |
| iShares Russell 2000 ETF | 1,206,194 | Apr 29, 2019 | 1.44% | 16,392,176 |
| Goldman Sachs Tr-Goldman Sachs Small/Mid Cap Growth Fund | 1,136,687 | Nov 29, 2018 | 1.36% | 15,208,872 |
| Fidelity Small Cap Growth Fund | 1,027,620 | Jan 30, 2019 | 1.23% | 14,468,889 |
| College Retirement Equities Fund-Stock Account | 1,014,969 | Sep 29, 2018 | 1.22% | 16,899,233 |