| 2.05% | % of Shares Held by All Insider |
| 121.21% | % of Shares Held by Institutions |
| 123.75% | % of Float Held by Institutions |
| 254 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Blackrock Inc. | 5,279,307 | Mar 30, 2019 | 15.63% | 67,997,474 |
| Vanguard Group, Inc. (The) | 3,756,733 | Mar 30, 2019 | 11.13% | 48,386,721 |
| Palo Alto Investors Lp | 3,421,306 | Mar 30, 2019 | 10.13% | 44,066,421 |
| Armistice Capital, LLC | 3,316,000 | Mar 30, 2019 | 9.82% | 42,710,080 |
| State Street Corporation | 2,823,826 | Mar 30, 2019 | 8.36% | 36,370,878 |
| Camber Capital Management LP | 2,650,000 | Mar 30, 2019 | 7.85% | 34,132,000 |
| Renaissance Technologies, LLC | 1,946,700 | Mar 30, 2019 | 5.77% | 25,073,496 |
| Robeco Institutional Asset Management B V | 1,304,639 | Mar 30, 2019 | 3.86% | 16,803,750 |
| Dimensional Fund Advisors LP | 1,097,961 | Mar 30, 2019 | 3.25% | 14,141,737 |
| Shaw D.E. & Co., Inc. | 1,037,759 | Mar 30, 2019 | 3.07% | 13,366,335 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,635,182 | May 30, 2019 | 4.84% | 15,583,284 |
| iShares Core S&P Smallcap ETF | 1,619,842 | May 30, 2019 | 4.80% | 15,437,094 |
| Vanguard Small-Cap Index Fund | 846,043 | Dec 30, 2018 | 2.51% | 12,851,393 |
| Vanguard Total Stock Market Index Fund | 842,524 | Dec 30, 2018 | 2.50% | 12,797,939 |
| iShares Russell 2000 ETF | 701,351 | May 30, 2019 | 2.08% | 6,683,875 |
| iShares S&P Smallcap 600 Value ETF | 581,123 | May 30, 2019 | 1.72% | 5,538,102 |
| Vanguard Small-Cap Growth Index Fund | 476,496 | Dec 30, 2018 | 1.41% | 7,237,974 |
| Vanguard Extended Market Index Fund | 470,873 | Dec 30, 2018 | 1.39% | 7,152,560 |
| iShares NASDAQ Biotechnology ETF | 355,259 | May 30, 2019 | 1.05% | 3,385,618 |
| DFA U.S. Small Cap Value Series | 326,494 | Jan 30, 2019 | 0.97% | 5,344,706 |