| 50.59% | % of Shares Held by All Insider |
| 51.75% | % of Shares Held by Institutions |
| 104.73% | % of Float Held by Institutions |
| 122 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vivo Capital, LLC | 5,575,785 | Mar 30, 2019 | 7.29% | 11,653,390 |
| Blackrock Inc. | 3,220,608 | Mar 30, 2019 | 4.21% | 6,731,070 |
| Ardsley Advisory Partners | 2,732,500 | Mar 30, 2019 | 3.57% | 5,710,925 |
| Vanguard Group, Inc. (The) | 2,047,341 | Mar 30, 2019 | 2.68% | 4,278,942 |
| Silverback Asset Management, LLC | 1,795,451 | Mar 30, 2019 | 2.35% | 3,752,492 |
| Hood River Capital Management LLC | 1,417,517 | Mar 30, 2019 | 1.85% | 2,962,610 |
| Tanaka Capital Management Inc | 913,873 | Mar 30, 2019 | 1.19% | 1,909,994 |
| Allianz Asset Management GmbH | 631,350 | Mar 30, 2019 | 0.83% | 1,319,521 |
| WS Management, LLP | 550,319 | Mar 30, 2019 | 0.72% | 1,150,166 |
| State Street Corporation | 539,134 | Mar 30, 2019 | 0.70% | 1,126,790 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Balanced Fund | 1,704,900 | May 30, 2019 | 2.23% | 5,779,611 |
| iShares NASDAQ Biotechnology ETF | 946,469 | May 30, 2019 | 1.24% | 3,208,529 |
| Vanguard Total Stock Market Index Fund | 894,783 | Dec 30, 2018 | 1.17% | 2,988,575 |
| Roxbury/Hood River Small Cap Growth Fund | 759,297 | Mar 30, 2019 | 0.99% | 1,586,930 |
| iShares Russell 2000 ETF | 650,138 | May 30, 2019 | 0.85% | 2,203,967 |
| Vanguard Extended Market Index Fund | 593,645 | Dec 30, 2018 | 0.78% | 1,982,774 |
| Fidelity Strategic Advisers Fidelity U.S. Total Stock Fund | 297,800 | May 30, 2019 | 0.39% | 1,009,542 |
| iShares Russell 2000 Value ETF | 263,489 | May 30, 2019 | 0.34% | 893,227 |
| Variable Insurance Products Fund III-Balanced Portfolio | 229,800 | May 30, 2019 | 0.30% | 779,022 |
| Fidelity Extended Market Index Fund | 222,319 | May 30, 2019 | 0.29% | 753,661 |