| 50.59% | % of Shares Held by All Insider |
| 51.75% | % of Shares Held by Institutions |
| 104.73% | % of Float Held by Institutions |
| 122 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vivo Capital, LLC | 5,575,785 | Dec 30, 2018 | 7.29% | 18,623,121 |
| Hood River Capital Management LLC | 3,568,872 | Dec 30, 2018 | 4.66% | 11,920,032 |
| Blackrock Inc. | 3,419,786 | Dec 30, 2018 | 4.47% | 11,422,085 |
| Vanguard Group, Inc. (The) | 1,656,578 | Dec 30, 2018 | 2.16% | 5,532,970 |
| Deutsche Bank Aktiengesellschaft | 1,626,582 | Dec 30, 2018 | 2.13% | 5,432,783 |
| Ardsley Advisory Partners | 1,389,500 | Dec 30, 2018 | 1.82% | 4,640,930 |
| Silverback Asset Management, LLC | 1,272,488 | Dec 30, 2018 | 1.66% | 4,250,109 |
| Gilder, Gagnon, Howe & Co. | 981,979 | Dec 30, 2018 | 1.28% | 3,279,809 |
| Tanaka Capital Management Inc | 794,495 | Dec 30, 2018 | 1.04% | 2,653,613 |
| WS Management, LLP | 629,104 | Dec 30, 2018 | 0.82% | 2,101,207 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| iShares NASDAQ Biotechnology ETF | 836,365 | Feb 27, 2019 | 1.09% | 3,964,370 |
| Roxbury/Hood River Small Cap Growth Fund | 823,236 | Dec 30, 2018 | 1.08% | 2,749,608 |
| iShares Russell 2000 ETF | 641,368 | Feb 27, 2019 | 0.84% | 3,040,084 |
| Vanguard Total Stock Market Index Fund | 609,083 | Sep 29, 2018 | 0.80% | 4,836,119 |
| Vanguard Extended Market Index Fund | 419,845 | Sep 29, 2018 | 0.55% | 3,333,569 |
| iShares Russell 2000 Value ETF | 246,902 | Feb 27, 2019 | 0.32% | 1,170,315 |
| Fidelity Extended Market Index Fund | 222,319 | Feb 27, 2019 | 0.29% | 1,053,792 |
| Bridgeway Funds Inc-Ultra Small Company Market Fund | 165,000 | Sep 29, 2018 | 0.22% | 1,310,100 |
| Tanaka Growth Fund | 146,141 | Aug 30, 2018 | 0.19% | 1,310,884 |
| Fidelity Small Cap Index Fund | 109,577 | Jan 30, 2019 | 0.14% | 371,466 |