|Bid||27.40 x 1000|
|Ask||27.99 x 1000|
|Day's Range||26.01 - 29.28|
|52 Week Range||5.67 - 60.00|
|Beta (5Y Monthly)||7.14|
|PE Ratio (TTM)||N/A|
|Earnings Date||Nov 10, 2020|
|Forward Dividend & Yield||N/A (N/A)|
|1y Target Est||61.00|
Initiates Multi-Center, Multi-Arm Trial Using Active Dose Identified in the Dose Escalation Phase of the TrialSEATTLE, WA / ACCESSWIRE / May 27, 2021 / Aptevo Therapeutics Inc. ("Aptevo") (NASDAQ:APVO), a clinical-stage biotechnology company focused on developing novel immuno-oncology therapeutics based on its proprietary ADAPTIRTM and ADAPTIR-FLEXTM platform technologies today announced that the company has initiated the expansion phase of lead anti-leukemia drug candidate, APVO436, in adult patients with acute myeloid leukemia (AML) with a multi-center, multi-arm trial using the active recommended dose identified in the dose escalation phase (Part 1) of the study.
Aptevo Therapeutics Inc (NASDAQ: APVO) has announced positive results from Phase 1 dose-escalation trial evaluating lead ADAPTIR candidate, APVO436, for acute myeloid leukemia and myelodysplastic syndromes (AML/MDS). The study met its primary endpoint of identification of an active dose level for advanced studies. The Company plans to submit the data for publication later this year. Of seven evaluable relapsed AML patients treated in Cohort 6, four showed stabilization of their leukemias. Of those four patients with disease stabilization, three patients lived over 246 days, over 261 days, and over 281 days, respectively, and one progressed after a month. Two relapsed AML patients, who experienced stabilization of their leukemia, achieved partial remission and subsequently a complete remission. No partial or complete remissions have been observed at APVO436 dose levels either lower or higher than the Cohort 6 dose level. APVO436 was generally well tolerated and demonstrated a favorable side effect profile, including the absence of severe or prolonged neutropenia, an often serious condition associated with CD123-targeting therapies. Price Action: APVO shares are up 9.7% at $27.71 during the market session on the last check Wednesday. See more from BenzingaClick here for options trades from BenzingaVistaGen Kick Starts Late-Stage Social Anxiety Disorder Study with PH94BDyadic's Stock Jumps On COVID-19 Vaccine Development Pact In India© 2021 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
* Dose Escalation Study of APVO436 Shows Favorable Safety Profile and No Severe Neutropenia, a Potentially Life-threatening Side Effect, Reported in a Significant Number of Patients Receiving CD123-Targeting Drugs * Dosing Level Established For Advanced Clinical TrialsSEATTLE, WA / ACCESSWIRE / May 26, 2021 / Aptevo Therapeutics Inc. ("Aptevo") (NASDAQ:APVO), a clinical-stage biotechnology company focused on developing novel immuno-oncology therapeutics based on its proprietary ADAPTIR™ and ADAPTIR-FLEX™ platform technologies, today announced positive results from the Company's Phase 1 dose escalation trial evaluating lead ADAPTIR candidate, APVO436, for the treatment of acute myeloid leukemia and myelodysplastic syndromes (AML/MDS).