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Aravive, Inc. (ARAV)

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Previous Close5.57
Open5.58
Bid5.63 x 800
Ask6.05 x 800
Day's Range5.45 - 6.23
52 Week Range3.34 - 15.62
Volume469,005
Avg. Volume214,788
Market Cap96.589M
Beta (5Y Monthly)3.20
PE Ratio (TTM)N/A
EPS (TTM)-1.92
Earnings DateNov 05, 2020 - Nov 09, 2020
Forward Dividend & YieldN/A (N/A)
Ex-Dividend DateN/A
1y Target Est27.75
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  • GlobeNewswire

    Aravive Reports Second Quarter 2020 Financial Results and Provides Recent Corporate Updates

    * Successfully completed Phase 1b trial of AVB-500 in Platinum Resistant Ovarian Cancer with encouraging clinical data showing 60% ORR in the subpopulation that has not previously been treated with bevacizumab * On-track to discuss the potential pivotal trial of AVB-500 with FDA this year * On-track to initiate Phase 1b/2 trial of AVB-500 in Clear Cell Renal Cell Carcinoma in 2H 2020 * Current cash and cash equivalents expected to fund operations into 2022HOUSTON, Aug. 03, 2020 (GLOBE NEWSWIRE) -- Aravive, Inc. (Nasdaq: ARAV), a clinical-stage oncology company developing transformative therapeutics, today announced recent corporate updates and financial results for the second quarter ended June 30, 2020.“Aravive has made significant progress in the second quarter of 2020, highlighted by the successful completion of our Phase 1b trial evaluating AVB-500 in platinum resistant ovarian cancer with encouraging clinical data setting us up to move into what could be a pivotal study with our lead program,” said Gail McIntyre, Ph.D., chief executive officer of Aravive. “A preliminary discussion with the FDA suggests an adaptive, randomized, controlled trial with biomarker-based stratification and an interim analysis to drop the control arm could potentially be an efficient pathway to approval. We are very encouraged by the Phase 1b trial results and look forward to formally discussing the data and our development plans with the FDA in the coming months. The Aravive team is also looking forward to advancing both the ovarian cancer and renal cancer programs over the next few months.”  Second Quarter 2020 Financial Results Revenue for the three and six months ended June 30, 2020 were $0 for both periods, compared to $3.1 million and $4.8 million for the same periods in 2019. Revenue for 2019 was derived solely from the Cancer Prevention Research Institute of Texas (CPRIT) grant.Total operating expenses for the three and six months ended June 30, 2020 were $5.7 million and $16.0 million, respectively, compared to $6.9 million and $14.4 million for the same periods in 2019.Total operating expenses for the three and six months ended June 30, 2020 included non-cash stock-based compensation expense of $0.5 million and $1.2 million, respectively, compared to $0.9 million and $2.0 million for the same periods in 2019. In addition, as previously reported, during the three months ended March 31, 2020, there was a one-time non-cash charge for impairment of the Company’s right-of-use asset and leasehold improvements of $2.9 million.For the three and six months ended June 30, 2020, Aravive reported a net loss of $5.0 million and $15.8 million, or $0.32 per share and $1.02 per share, respectively, compared to a net loss of $3.0 million and $7.7 million, or $0.27 per share and $0.69 per share, for the same periods in 2019.Cash Position As of June 30, 2020, cash and cash equivalents was $60.1 million, compared to $65.1 million as of December 31, 2019. The Company expects that its current cash and cash equivalents will be sufficient to fund its operating plans into 2022.   Recent Corporate Highlights• AVB-500 in Platinum Resistant Ovarian Cancer (PROC): On July 23, 2020, the Company announced the successful completion of its Phase 1b trial of AVB-500 in PROC and selection of the recommended Phase 2 dose.  o AVB-500 plus paclitaxel showed an overall Investigator-assessed best response rate (per RECIST V1.1) of 35% (95% CI of 16% to 57%) across all dosing cohorts with 2 complete responses (CR) and 6 partial responses (PR). These data compare favorably to the average response rate in platinum-resistant ovarian cancer patients of 10-15%.1  oThe Company is encouraged with 60% ORR in the sub population that has not been previously treated with bevacizumab and 71% among those with high plasma sAXL/GAS6 ratio, a potential biomarker of response.  oAnalysis of all safety data to date showed that AVB-500 has been well-tolerated with no dose-limiting toxicities or unexpected safety signals.  oWhile the Phase 1b trial was a safety trial and not powered to demonstrate efficacy, all 5 patients in the 15 mg/kg cohort experienced clinical benefit, with 1 CR (patient continues to maintain CR for 3 months on AVB-500 alone following discontinuation of paclitaxel), 2 partial responses, and 2 stable disease.  oThe safety, pharmacokinetic and clinical activity at the 15 mg/kg dose support advancing 15 mg/kg AVB-500 into the next, potentially registrational enabling PROC trial. An interim analysis of this study is expected in 2021. • AVB-500 in Clear Cell Renal Cell Carcinoma (ccRCC): Aravive is on-track to initiate a Phase 1b/2 trial of AVB-500 in ccRCC in the second half of 2020. This is an open-label study which is expected to provide safety, pharmacokinetic, and preliminary clinical activity during the upcoming year. This study will also explore the biomarkers that have been identified during the PROC study. • Investigator-Sponsored Trials (ISTs): The Company expects to provide an update on the ongoing ISTs within the next 12 months (assuming COVID-19 and other unforeseen circumstances do not interfere). •  Strategic Decision to Focus on Oncology Assets and Pipeline Expansion: The Company announced a new strategic focus for AVB-500 in oncology. Following the positive results from the AVB-500 Phase 1 trial in PROC, Aravive plans to focus its resources on advancing the development of AVB-500 in PROC, ccRCC and potentially additional oncology indications.  o Recent preclinical data with AVB-500 has highlighted its promise to be combined with various oncology compounds (e.g., PARP inhibitors, bevacizumab, immunotherapy as well as cytotoxic agents) to support the Company’s pipeline expansion in oncology indications.  o Specifically, in addition to Aravive’s focus on PROC, the Company is also considering moving AVB-500 into frontline therapy in Ovarian cancer in combination with PAC/Platinum/Bevacizumab, all of which have biological rationale and supportive data for potential synergy/additive anti-tumor effects. Importantly, the safety profile of AVB-500 suggests there may not be added toxicity to the first line cocktails used in frontline metastatic ovarian cancer.   o The Company expects to announce expansion plans during 2021. “I am delighted at the achievements that Gail and her team have made with AVB-500 and we strongly support moving the program forward. With a renewed focus on oncology assets, AVB-500 offers a first-and potentially best-in-class opportunity in oncology,” said Fred Eshelman, Pharm.D., chairman of the board of directors. “On behalf of the Aravive Board, we look forward to continuing to grow our business, add talent to our management team and Board and assess business development opportunities around our pipeline and ex-U.S.”About Aravive Aravive, Inc. (Nasdaq: ARAV) is a clinical-stage oncology company developing transformative treatments designed to halt the progression of life-threatening diseases. Aravive’s lead product candidate, AVB-500, is an ultra-high affinity decoy protein that targets the GAS6-AXL signaling pathway. On July 23, 2020, Aravive announced the successful completion of a Phase 1b trial of AVB-500 in platinum resistant ovarian cancer and selection of the recommended Phase 2 dose, 15 mg/kg. Analysis of all safety data to date showed that AVB-500 has been generally well-tolerated with no dose-limiting toxicities or unexpected safety signals. While the Phase 1b trial was a safety trial and not powered to demonstrate efficacy, all 5 patients in the 15 mg/kg cohort experienced clinical benefit, with 1 complete response (CR), 2 partial responses, and 2 stable disease. Across all cohorts, AVB-500 plus paclitaxel data showed an ORR of 35% (8/23 patients, including 2 CRs) and a 60% ORR in paclitaxel patients who had not previously been given bevacizumab. For more information, please visit www.aravive.com.Forward-Looking Statements This communication contains forward-looking statements (including within the meaning of Section 21E of the United States Securities Exchange Act of 1934, as amended, and Section 27A of the United States Securities Act of 1933, as amended), express or implied, such as advancing both the ovarian cancer and renal cancer programs over the next few months, being on-track to discuss the potentially pivotal study with FDA this year and initiation of Phase 1b/2 trial of AVB-500 in clear cell renal cell carcinoma in second half of 2020, moving into what could be a pivotal trial, expanding the pipeline in oncology and announcement of expansion plans in 2021, an adaptive, randomized, controlled trial with biomarker-based stratification and an interim analysis to drop the control arm potentially being an efficient pathway to approval, an interim analysis of the PROC trial in 2021, current cash and cash equivalents expected to fund operations into 2022, ISTs providing information within the next twelve months, moving AVB-500 into frontline therapy in ovarian cancer and the suggestion that AVB-500 may not be added toxicity to the first line cocktails used in frontline metastatic ovarian cancer and continuing to grow the business, add talent to the management and Board and assess business development opportunities around the pipeline and ex-U.S. Forward-looking statements are based on current beliefs and assumptions, are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results to differ materially from those contained in any forward-looking statement as a result of various factors, including, but not limited to, risks and uncertainties related to: the Company's ability to design and obtain approval for a randomized, controlled trial with an interim analysis and drop the control arm that potentially could be a pathway to approval, the ability to properly fund the Company, the ability to initiate the open-label ccRCC study and potentially pivotal PROC study, the ability to provide preliminary safety, pharmacokinetic and tumor response data from the ccRCC study, interim analysis data on the potentially pivotal study by the end of 2021 and announcement of pipeline expansion plans in 2021, providing information from ISTs within the next twelve months, the ability to move AVB-500 into frontline therapy, the ability to fund operations into 2022 with current cash and cash equivalents, the ability of the new directors and management team to deliver on the Company's strategic vision and execute on its business plan, the impact of COVID-19 on the Company's clinical strategy, clinical trials, supply chain and fundraising, the Company's ability to expand development into additional oncology indications, the Company's dependence upon AVB-500, AVB-500's ability to have favorable results in clinical trials and ISTs, the clinical trials of AVB-500 having results that are as favorable as those of preclinical and clinical trials, the ability to receive regulatory approval, potential delays in the Company's clinical trials due to regulatory requirements or difficulty identifying qualified investigators or enrolling patients especially in light of the COVID-19 pandemic; the risk that AVB-500 may cause serious side effects or have properties that delay or prevent regulatory approval or limit its commercial potential; the risk that the Company may encounter difficulties in manufacturing AVB-500; if AVB-500 is approved, risks associated with its market acceptance, including pricing and reimbursement; potential difficulties enforcing the Company's intellectual property rights; the Company's reliance on its licensor of intellectual property and financing needs. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2019, recent Current Reports on Form 8-K and subsequent filings with the SEC. Except as required by applicable law, the Company undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise. Contacts: Media: Sheryl Seapy, W2O sseapy@w2ogroup.com (949) 903-4750Investors: Luke Heagle, W2O  lheagle@w2ogroup.com (910) 726-1372 Aravive, Inc. Condensed Consolidated Statements of Operations (in thousands, except per share amounts) (unaudited) Three Months Ended Six Months Ended   June 30, June 30,   2020  2019 2020  2019  Revenue               Grant revenue$—  $3,054 $—  $4,753  Operating expenses               Research and development 2,522   3,637  6,014   6,485  General and administrative 3,201   3,291  7,151   7,881  Loss on impairment of long-lived assets —   —  2,870   —  Total operating expenses 5,723   6,928  16,035   14,366  Loss from operations (5,723)  (3,874) (16,035)  (9,613) Interest income 26   233  243   579  Other income (expense), net 656   597  (45)  1,286  Net loss$(5,041) $(3,044)$(15,837) $(7,748) Net loss per share- basic and diluted$(0.32) $(0.27)$(1.02) $(0.69) Weighted-average common shares used to compute basic and diluted net loss per share 15,902   11,280  15,457   11,277  Aravive, Inc. Condensed Consolidated Balance Sheets (in thousands) June 30,  December 31,   2020  2019   (unaudited)      Assets:        Cash and cash equivalents$60,062  $65,134  Restricted cash 2,429   2,423  Other assets 3,128   5,867  Operating lease right-of-use assets 5,394   8,697  Total assets$71,013  $82,121  Liabilities and stockholders' equity:        Accounts payable and accrued liabilities$2,276  $2,575  Operating lease obligation 8,995   10,233  Contingent payable 295   264  Total liabilities 11,566   13,072  Total stockholders' equity 59,447   69,049  Total liabilities and stockholders’ equity$71,013  $82,121  * * *1 A Davis et al., Gynecologic Oncology 133 (2014) 624–631

  • GlobeNewswire

    Aravive to Participate in Upcoming Virtual Investor Conferences in August

    HOUSTON, July 30, 2020 (GLOBE NEWSWIRE) -- Aravive, Inc. (Nasdaq: ARAV), a clinical-stage oncology company developing transformative therapeutics, today announced that the Company will present and conduct one-on-one meetings at the following three virtual investor conferences in August: * William Blair Biotech Focus Conference on Thursday, August 6, 2020, at 10:00 a.m. ET * BTIG Biotechnology Conference on Monday, August 10, 2020, at 9:30 a.m. ET * Wedbush PacGrow Healthcare Conference on Tuesday, August 11, 2020, at 1:45 p.m. ETLive webcasts and audio archives of the presentations will be available at http://ir.aravive.com.About Aravive Aravive, Inc. (Nasdaq: ARAV) is a clinical-stage oncology company developing transformative treatments designed to halt the progression of life-threatening diseases. Aravive’s lead product candidate, AVB-500, is an ultra-high affinity decoy protein that targets the GAS6-AXL signaling pathway. On July 23, 2020, Aravive announced the successful completion of a Phase 1b trial of AVB-500 in platinum resistant ovarian cancer and selection of the recommended Phase 2 dose. Analysis of all safety data to date showed that AVB-500 has been generally well-tolerated with no dose-limiting toxicities or unexpected safety signals. While the Phase 1b trial was a safety trial and not powered to demonstrate efficacy, all 5 patients in the 15 mg/kg cohort experienced clinical benefit, with 1 complete response (CR), 2 partial responses, and 2 stable disease. Across all cohorts, AVB-500 plus paclitaxel data showed an ORR of 35% (8/23 patients, including 2 CRs). For more information, please visit www.aravive.com.Contacts: Media: Sheryl Seapy, W2O sseapy@w2ogroup.com (949) 903-4750Investors: Luke Heagle, W2O  lheagle@w2ogroup.com (910) 726-1372

  • GlobeNewswire

    Aravive Announces Successful Completion of Phase 1b Trial Evaluating AVB-500 in Platinum Resistant Ovarian Cancer

    Identifies Recommended Phase 2 Dose for Continued Clinical Development of AVB-500  in Platinum Resistant Ovarian CancerAravive to Host Conference Call and Webcast Today at 8:30 a.m. ETHOUSTON, July 23, 2020 (GLOBE NEWSWIRE) -- Aravive, Inc. (Nasdaq: ARAV), a clinical-stage oncology company developing transformative therapeutics, today announced the successful completion of the Phase 1b trial of its AVB-500 drug candidate in platinum resistant ovarian cancer (PROC) and selection of the recommended Phase 2 dose (RP2D).“Aravive is grateful to the patients and their physicians who participated in this trial,” said Gail McIntyre, Ph.D., chief executive officer at Aravive. “We are very encouraged by the potential of AVB-500 to improve responses and progression free survival in combination with chemotherapy in platinum resistant ovarian cancer. The information we have obtained from the clinical data together with some informal preliminary feedback from the FDA have helped inform our Phase 2/3 trial strategy. We look forward to formally discussing these results and our development plan with the FDA by the end of 2020.”Phase 1b Results The safety of AVB-500 has been studied in 84 subjects, including 31 healthy volunteers in a Phase 1a trial and 53 patients with PROC in a Phase 1b trial (40 in 10 mg/kg cohort, 6 in 15 mg/kg cohort, and 7 in 20 mg/kg cohort). The primary objective of the PROC trial was to assess safety of AVB-500 in combination with paclitaxel (PAC) or pegylated liposomal doxorubicin (PLD). Secondary endpoints included objective response rate (ORR), CA-125 response, clinical benefit rate, progression free survival (PFS), overall survival, pharmacokinetic (PK) profile, GAS6 serum levels, and anti-drug antibody titers.Safety Data: Analysis of all safety data to date demonstrates that AVB-500 has been generally well-tolerated with no dose-limiting toxicities or unexpected safety signals. There have been no AVB-500-related SAEs reported to date. There were two types of adverse events that were considered related to AVB-500, as determined by an independent medical monitor: infusion reactions and fatigue. A premedication regimen was designed and implemented during the trial to manage potential infusion reactions.Pharmacokinetics: Prior data analysis of 31 patients from the 10 mg/kg cohort showed that blood trough levels of AVB-500 demonstrated statistically significant correlation with clinical activity, as patients who achieved minimal efficacious concentration (MEC) >13.8 mg/L demonstrated a greater likelihood of response and prolonged PFS. Updated modeling using actual data from all enrolled patients demonstrated that 59%, 84%, and 93% of patients achieved MEC at doses of 10 mg/kg, 15 mg/kg, and 20 mg/kg, respectively. Furthermore, at 20 mg/kg, a large percentage of subjects is projected to have trough levels greater than 4 times the MEC. These data suggest that at 15 mg/kg, the pharmacokinetics of AVB-500 start to plateau and support the choice of 15 mg/kg as RP2D for AVB-500.Preliminary Efficacy: While the Phase 1b trial was a safety trial and not powered to demonstrate efficacy, the investigator-assessed best response (RECIST V1.1) to AVB-500 across all cohorts supports promising clinical activity:10 mg/kg cohort, 37 out of 40 patients evaluable: * 31% ORR (5/16) among those treated with AVB-500 in combination with PAC, with 1 complete response (CR). Patients given AVB-500 plus PAC who achieved MEC of AVB-500 demonstrated improved ORR of 50% (4/8), with 1 CR. * The PFS among those who achieved MEC of AVB-500 was 7.5 months versus 2.28 months with those below MEC (p=0.0062). * 21.6% ORR (8/37) in all evaluable patients, regardless of their MEC or use of PAC or PLD. * All responses have been confirmed.15 mg/kg cohort, 5 out of 6 patients evaluable: * All 5 patients in this cohort experienced clinical benefit, with 1 CR (continuing to show CR 3 months after discontinuing chemotherapy while on AVB-500 as single agent), 2 partial responses (PR), and 2 stable disease (SD). * All responses have been confirmed.20 mg/kg cohort, 7 out of 7 patients evaluable: * Of the 7 patients in this cohort, there was 1 PR (with CR of target lesion; not confirmed), 1 SD, and 5 with progressive disease (PD). * A post-hoc analysis of tumor expression showed that 4 patients whose best response was PD did not express GAS6 (3) and/or had low amounts of AXL (2) on immunohistopathology of their tumors. While they were enrolled per protocol in the Phase 1b trial, these patients do not appear to be representative of the eventual AVB-500 target population, as they are mostly rare subtypes of PROC and such patients based on their clinical characteristics will not be eligible for the planned Phase 2/3 trial.Other notable findings: * AVB-500 plus PAC appeared to perform better than AVB-500 plus PLD. * Across all cohorts, AVB-500 plus PAC data show an ORR of 35% (8/23, including 2 CRs) compared to ORR of 15% (4/26) in AVB-500 plus PLD.   * AVB-500 plus chemo appeared to perform better in patients without previous exposure to bevacizumab. * In a subgroup analysis of patients who had not been previously exposed to bevacizumab in their prior lines of therapy, AVB-500 yielded an ORR of 60% (6/10 including 2 CR) when combined with PAC and an ORR of 19% (3/16) when combined with PLD. For reference, control arms of the third-party AURELIA Trial of bevacizumab (NCT00976911) showed ORR of 30.2% (out of 55 patients total) with PAC alone and 7.8% (out of 64 patients total) with PLD alone.   * Serum levels of soluble AXL (sAXL)/GAS6 ratio seemed to correlate with response to AVB-500. * In the entire Phase 1b cohort, patients with a high sAXL/GAS6 ratio had 30% ORR (10/33) versus 0% ORR (0/15) in patients with a low sAXL/GAS6 ratio. In the PAC cohort, patients with a high sAXL/GAS6 ratio had 43% ORR (6/14) versus 0% ORR (0/7) in patients with a low sAXL/GAS6 ratio. Notably, patients with high sAXL/GAS6 ratio who had not previously received bevacizumab achieved ORR of 71% (5/7). * Historically, high sAXL has been associated with a poor prognosis; however, AVB-500 plus PAC or PLD appeared correlated with improved clinical outcomes in this population. * Use of serum biomarkers such as sAXL/GAS6 ratio as potential stratification biomarker(s) will be explored in future clinical trials. “Improved therapeutic approaches, especially targeted therapies, are urgently needed for patients with ovarian cancer who are resistant to standard of care therapy and have limited treatment options,” said Katherine Fuh, M.D., Ph.D., Assistant Professor, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO. “AVB-500’s novel mechanism of action has the potential to be combined with any number of anticancer agents, including DNA-damaging agents, PARP inhibitors, bevacizumab as well as immuno-oncology agents and check point inhibitors to change the way we treat ovarian cancer.”Conference Call Information Aravive will host a live conference call and webcast at 8:30 a.m. ET today to discuss these clinical data. The conference call may be accessed by dialing (844) 281-9845 (domestic) and (314) 888-4254 (international) and referring to conference ID 6277266. A webcast of the conference call and an accompanying slide presentation will be available in the Investors section of the Aravive website at https://ir.aravive.com. The archived webcast will be available on Aravive’s website after the conference call.About AVB500-OC-002 Aravive initiated a Phase 1b dose-escalation trial (AVB500-OC-002) evaluating AVB-500 in combination with pegylated liposomal doxorubicin (PLD) or paclitaxel (PAC) for patients with platinum resistant ovarian cancer (PROC) in December 2018. Aravive reported positive preliminary data from the Phase 1b trial at 10 mg/kg in November 2019, demonstrating a relationship between AVB-500 blood levels and anti-tumor response. Additionally, AVB-500 is being studied in Investigator-sponsored Phase 1/2 trials, in combination with durvalumab in patients with platinum-resistant recurrent epithelial ovarian cancer and with avelumab in patients with advanced urothelial Carcinoma (COAXIN).About AVB-500 AVB-500 is a therapeutic recombinant fusion protein that has been shown to neutralize GAS6 activity by binding to GAS6 with very high affinity in preclinical models. In doing so, AVB-500 selectively inhibits the GAS6-AXL signaling pathway which is upregulated in multiple cancer types including ovarian cancer. In preclinical studies, GAS6-AXL inhibition has shown anti-tumor activity in combination with a variety of anticancer therapies including radiation therapy, immuno-oncology agents, and chemotherapeutic drugs that affect DNA replication and repair. Increased expression of AXL and GAS6 in tumors has been correlated with poor prognosis and decreased survival and has been implicated in therapeutic resistance to conventional chemotherapeutics and targeted therapies. AVB-500 is currently being evaluated in clinical trials and has been granted Fast Track Designation by The U.S. Food and Drug Administration (FDA) in platinum-resistant recurrent ovarian cancer.About Aravive Aravive, Inc. (Nasdaq: ARAV) is a clinical-stage oncology company developing transformative treatments designed to halt the progression of life-threatening diseases. Aravive’s lead product candidate, AVB-500, is an ultra-high affinity decoy protein that targets the GAS6-AXL signaling pathway. Aravive recently initiated a discovery program to develop a high affinity bispecific program targeting CCN2 (CTGF) for treatment of cancer and fibrosis. For more information, please visit www.aravive.com.Forward-Looking Statements This communication contains forward-looking statements (including within the meaning of Section 21E of the United States Securities Exchange Act of 1934, as amended, and Section 27A of the United States Securities Act of 1933, as amended), express or implied, such as the potential of AVB-500 to improve responses and progression free survival in combination with chemotherapy in platinum resistant ovarian cancer, the potential of a Phase 2/3 trial, and the potential of combining AVB-500’s novel mechanism of action with other anticancer agents, including DNA-damaging agents, PARP inhibitors, bevacizumab as well as immuno-oncology agents and check point inhibitors to change the way we treat ovarian cancer. Forward-looking statements are based on current beliefs and assumptions, are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results to differ materially from those contained in any forward-looking statement as a result of various factors, including, but not limited to, risks and uncertainties related to: the Company's ability to show the potential of AVB-500 to improve responses and progression free survival in combination with chemotherapy in platinum resistant ovarian cancer, the Company’s ability to successfully combine AVB-500’s novel mechanism of action with other anticancer agents, the ability to properly fund the Company, the ability of the new directors and management team to deliver on the Company's strategic vision and execute on its business plan, the impact of COVID-19 on the Company's clinical strategy, clinical trials, supply chain and fundraising, the Company's ability to expand development into additional oncology and fibrotic indications, the Company's dependence upon AVB-500, AVB-500's ability to have favorable results in clinical trials, the clinical trials of AVB-500 having results that are as favorable as those of preclinical and clinical trials, the ability to receive regulatory approval, potential delays in the Company's clinical trials due to regulatory requirements or difficulty identifying qualified investigators or enrolling patients especially in light of the COVID-19 pandemic; the risk that AVB-500 may cause serious side effects or have properties that delay or prevent regulatory approval or limit its commercial potential; the risk that the Company may encounter difficulties in manufacturing AVB-500; if AVB-500 is approved, risks associated with its market acceptance, including pricing and reimbursement; potential difficulties enforcing the Company's intellectual property rights; the Company's reliance on its licensor of intellectual property and financing needs. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2019, recent Current Reports on Form 8-K and subsequent filings with the SEC. Except as required by applicable law, the Company undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise.Contacts: Media: Sheryl Seapy, W2O sseapy@w2ogroup.com (949) 903-4750Investors: Luke Heagle, W2O  lheagle@w2ogroup.com (910) 726-1372

  • What Kind Of Investors Own Most Of Aravive, Inc. (NASDAQ:ARAV)?
    Simply Wall St.

    What Kind Of Investors Own Most Of Aravive, Inc. (NASDAQ:ARAV)?

    A look at the shareholders of Aravive, Inc. (NASDAQ:ARAV) can tell us which group is most powerful. Institutions often...

  • GlobeNewswire

    Aravive Added to the Russell 2000® and Russell 3000® Indexes

    Aravive, Inc. (ARAV), a clinical-stage biopharmaceutical company developing treatments designed to halt the progression of life-threatening diseases, including cancer and fibrosis, today announced that the Company has been added to the Russell 2000® and Russell 3000® Indexes, effective June 29, 2020, as part of the 2020 Russell U.S. indexes reconstitution. “Our inclusion in the Russell indexes reflects the meaningful progress we have made toward our goal of changing the treatment paradigm for people living with cancer,” said Gail McIntyre, Ph.D., chief executive officer of Aravive. Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies.

  • Aravive (ARAV) Stock Moves -1.47%: What You Should Know
    Zacks

    Aravive (ARAV) Stock Moves -1.47%: What You Should Know

    In the latest trading session, Aravive (ARAV) closed at $14.11, marking a -1.47% move from the previous day.

  • Aravive (ARAV) Dips More Than Broader Markets: What You Should Know
    Zacks

    Aravive (ARAV) Dips More Than Broader Markets: What You Should Know

    Aravive (ARAV) closed at $13.55 in the latest trading session, marking a -0.88% move from the prior day.

  • Hedge Funds Are Dumping Aravive, Inc. (ARAV)
    Insider Monkey

    Hedge Funds Are Dumping Aravive, Inc. (ARAV)

    In this article you are going to find out whether hedge funds think Aravive, Inc. (NASDAQ:ARAV) is a good investment right now. We like to check what the smart money thinks first before doing extensive research on a given stock. Although there have been several high profile failed hedge fund picks, the consensus picks among […]

  • GlobeNewswire

    Aravive To Present at The 2020 RBC Capital Markets Global Healthcare Conference

    HOUSTON, May 12, 2020 -- Aravive, Inc. (Nasdaq: ARAV), a clinical-stage biopharmaceutical company developing treatments designed to halt the progression of life-threatening.

  • GlobeNewswire

    Aravive Reports First Quarter 2020 Financial Results and Provides Recent Corporate Updates

    HOUSTON, May 06, 2020 -- Aravive, Inc. (Nasdaq: ARAV), a clinical-stage biopharmaceutical company developing treatments designed to halt the progression of life-threatening.