| 0.16% | % of Shares Held by All Insider |
| 85.23% | % of Shares Held by Institutions |
| 85.36% | % of Float Held by Institutions |
| 247 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Wellington Management Company, LLP | 4,979,681 | Jun 29, 2019 | 9.99% | 291,958,697 |
| Blackrock Inc. | 4,795,930 | Jun 29, 2019 | 9.63% | 281,185,375 |
| Vanguard Group, Inc. (The) | 4,551,498 | Jun 29, 2019 | 9.13% | 266,854,327 |
| FMR, LLC | 2,050,062 | Jun 29, 2019 | 4.11% | 120,195,135 |
| Partner Fund Management, L.P. | 1,828,378 | Jun 29, 2019 | 3.67% | 107,197,802 |
| State Street Corporation | 1,752,817 | Jun 29, 2019 | 3.52% | 102,767,660 |
| Primecap Management Company | 1,525,200 | Jun 29, 2019 | 3.06% | 89,422,476 |
| Perceptive Advisors Llc | 1,380,171 | Jun 29, 2019 | 2.77% | 80,919,425 |
| AllianceBernstein, L.P. | 1,053,855 | Jun 29, 2019 | 2.12% | 61,787,518 |
| Eagle Asset Management Inc | 937,252 | Jun 29, 2019 | 1.88% | 54,951,084 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 1,344,500 | Mar 30, 2019 | 2.70% | 60,273,935 |
| Vanguard Small-Cap Index Fund | 1,286,014 | Mar 30, 2019 | 2.58% | 57,652,007 |
| iShares Russell 2000 ETF | 1,086,200 | Jul 30, 2019 | 2.18% | 68,083,016 |
| Fidelity Select Portfolios - Biotechnology | 1,002,973 | Jun 29, 2019 | 2.01% | 58,804,306 |
| Vanguard Small-Cap Growth Index Fund | 725,410 | Mar 30, 2019 | 1.46% | 32,520,130 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 708,517 | Jul 30, 2019 | 1.42% | 44,409,845 |
| Vanguard Extended Market Index Fund | 694,674 | Mar 30, 2019 | 1.39% | 31,142,235 |
| Carillon Ser Tr-Carillon Eagle Small Cap Growth Fund | 665,583 | Jun 29, 2019 | 1.34% | 39,023,131 |
| Primecap Odyssey Aggressive Growth Fund | 619,200 | Jun 29, 2019 | 1.24% | 36,303,696 |
| Primecap Odyssey Growth Fund | 617,100 | Jun 29, 2019 | 1.24% | 36,180,573 |