| 0.16% | % of Shares Held by All Insider |
| 85.23% | % of Shares Held by Institutions |
| 85.36% | % of Float Held by Institutions |
| 247 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Wellington Management Company, LLP | 4,955,467 | Mar 30, 2019 | 10.00% | 222,153,585 |
| Blackrock Inc. | 4,757,174 | Mar 30, 2019 | 9.60% | 213,264,110 |
| Vanguard Group, Inc. (The) | 4,557,839 | Mar 30, 2019 | 9.19% | 204,327,922 |
| Partner Fund Management, L.P. | 3,255,230 | Mar 30, 2019 | 6.57% | 145,931,960 |
| FMR, LLC | 2,072,048 | Mar 30, 2019 | 4.18% | 92,889,911 |
| State Street Corporation | 1,948,764 | Mar 30, 2019 | 3.93% | 87,363,090 |
| Primecap Management Company | 1,462,200 | Mar 30, 2019 | 2.95% | 65,550,426 |
| Perceptive Advisors Llc | 1,400,171 | Mar 30, 2019 | 2.82% | 62,769,665 |
| Eagle Asset Management Inc | 939,507 | Mar 30, 2019 | 1.90% | 42,118,098 |
| Pictet Asset Management Ltd | 861,345 | Mar 30, 2019 | 1.74% | 38,614,096 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 1,312,509 | Dec 30, 2018 | 2.65% | 51,122,225 |
| Vanguard Small-Cap Index Fund | 1,266,682 | Dec 30, 2018 | 2.56% | 49,337,263 |
| iShares Russell 2000 ETF | 1,023,852 | Apr 29, 2019 | 2.07% | 46,841,229 |
| Fidelity Select Portfolios - Biotechnology | 1,002,973 | Apr 29, 2019 | 2.02% | 45,886,014 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 963,698 | Apr 29, 2019 | 1.94% | 44,089,183 |
| Vanguard Small-Cap Growth Index Fund | 717,578 | Dec 30, 2018 | 1.45% | 27,949,663 |
| Vanguard Extended Market Index Fund | 678,624 | Dec 30, 2018 | 1.37% | 26,432,404 |
| Carillon Ser Tr-Carillon Eagle Small Cap Growth Fund | 665,583 | Mar 30, 2019 | 1.34% | 29,838,085 |
| Vanguard Explorer Fund, Inc. | 612,048 | Jan 30, 2019 | 1.23% | 28,135,846 |
| Primecap Odyssey Growth Fund | 590,000 | Mar 30, 2019 | 1.19% | 26,449,700 |