| 22.43% | % of Shares Held by All Insider |
| 39.41% | % of Shares Held by Institutions |
| 50.81% | % of Float Held by Institutions |
| 8 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Price (T.Rowe) Associates Inc | 7,178,036 | Jun 29, 2019 | 17.04% | 826,550,845 |
| FMR, LLC | 4,692,706 | Jun 29, 2019 | 11.14% | 540,365,095 |
| RA Capital Management, LLC | 4,132,442 | Jun 29, 2019 | 9.81% | 475,850,696 |
| Orbimed Advisors LLC. | 3,846,673 | Jun 29, 2019 | 9.13% | 442,944,395 |
| Baker Brothers Advisors, LLC | 3,390,270 | Jun 29, 2019 | 8.05% | 390,389,590 |
| Vivo Capital, LLC | 2,060,135 | Jun 29, 2019 | 4.89% | 237,224,545 |
| Avoro Capital Advisors LLC | 1,970,000 | Jun 29, 2019 | 4.68% | 226,845,500 |
| Eventide Asset Management LLC | 1,698,648 | Jun 29, 2019 | 4.03% | 195,599,317 |
| Artisan Partners Limited Partnership | 1,593,267 | Jun 29, 2019 | 3.78% | 183,464,695 |
| Farallon Capital Management LLC | 1,540,000 | Jun 29, 2019 | 3.65% | 177,331,000 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Price (T.Rowe) New Horizons Fund | 1,493,789 | Jun 29, 2019 | 3.55% | 172,009,803 |
| Price (T.Rowe) Health Sciences Fund | 1,267,432 | Jun 29, 2019 | 3.01% | 145,944,794 |
| Mutual Fund Ser Tr-Eventide Gilead Fund | 1,123,000 | Dec 30, 2018 | 2.67% | 70,355,950 |
| Fidelity Select Portfolios - Health Care | 730,000 | Jun 29, 2019 | 1.73% | 84,059,500 |
| Price (T.Rowe) Small Cap Stock Fund | 669,162 | Jun 29, 2019 | 1.59% | 77,054,004 |
| Fidelity Select Portfolios - Biotechnology | 649,309 | Jun 29, 2019 | 1.54% | 74,767,931 |
| Mutual Fund Ser Tr-Eventide Healthcare & Life Sciences Fund | 575,648 | Dec 30, 2018 | 1.37% | 36,064,347 |
| iShares NASDAQ Biotechnology ETF | 450,727 | Jun 29, 2019 | 1.07% | 51,901,214 |
| Fidelity Advisor Biotechnology Fund | 440,206 | Jun 29, 2019 | 1.04% | 50,689,720 |
| Invesco Oppenheimer International Small-Mid Company Fund | 424,570 | Feb 27, 2019 | 1.01% | 30,917,187 |