| 4.86% | % of Shares Held by All Insider |
| 111.63% | % of Shares Held by Institutions |
| 117.34% | % of Float Held by Institutions |
| 182 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 6,417,956 | Mar 30, 2019 | 13.86% | 255,113,751 |
| Baupost Group, Inc,.(The) LLC | 6,380,519 | Mar 30, 2019 | 13.77% | 253,625,630 |
| Redmile Group, LLC | 4,485,417 | Mar 30, 2019 | 9.68% | 178,295,325 |
| Blackrock Inc. | 3,484,425 | Mar 30, 2019 | 7.52% | 138,505,893 |
| Vanguard Group, Inc. (The) | 2,879,314 | Mar 30, 2019 | 6.22% | 114,452,731 |
| Camber Capital Management LP | 2,000,000 | Mar 30, 2019 | 4.32% | 79,500,000 |
| JP Morgan Chase & Company | 1,917,903 | Mar 30, 2019 | 4.14% | 76,236,644 |
| Bridger Management LLC | 1,752,690 | Mar 30, 2019 | 3.78% | 69,669,427 |
| Price (T.Rowe) Associates Inc | 1,751,752 | Mar 30, 2019 | 3.78% | 69,632,142 |
| State Street Corporation | 1,694,026 | Mar 30, 2019 | 3.66% | 67,337,533 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Carillon Ser Tr-Carillon Eagle Small Cap Growth Fund | 1,220,241 | Mar 30, 2019 | 2.63% | 48,504,579 |
| Vanguard Total Stock Market Index Fund | 1,032,865 | Dec 30, 2018 | 2.23% | 35,881,730 |
| Fidelity Select Portfolios - Biotechnology | 1,015,143 | Apr 29, 2019 | 2.19% | 34,108,804 |
| Fidelity Select Portfolios - Health Care | 1,000,000 | Apr 29, 2019 | 2.16% | 33,600,000 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 877,844 | Apr 29, 2019 | 1.90% | 29,495,558 |
| iShares Russell 2000 ETF | 861,681 | Apr 29, 2019 | 1.86% | 28,952,481 |
| Price (T.Rowe) Health Sciences Fund | 777,892 | Mar 30, 2019 | 1.68% | 30,921,207 |
| Fidelity Advisor Biotechnology Fund | 692,124 | Apr 29, 2019 | 1.49% | 23,255,366 |
| Price (T.Rowe) New Horizons Fund | 668,605 | Mar 30, 2019 | 1.44% | 26,577,048 |
| Federated Kaufmann Fund | 631,406 | Mar 30, 2019 | 1.36% | 25,098,388 |