AZN - AstraZeneca PLC

NYSE - NYSE Delayed Price. Currency in USD
54.72
-0.44 (-0.80%)
At close: 4:00PM EDT

54.72 0.00 (0.00%)
After hours: 6:28PM EDT

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Performance Outlook
  • Short Term
    2W - 6W
  • Mid Term
    6W - 9M
  • Long Term
    9M+
Previous Close55.16
Open54.49
Bid54.33 x 1400
Ask54.69 x 1200
Day's Range54.10 - 54.74
52 Week Range36.15 - 57.44
Volume4,272,511
Avg. Volume5,335,292
Market Cap139.879B
Beta (5Y Monthly)0.31
PE Ratio (TTM)94.59
EPS (TTM)0.58
Earnings DateN/A
Forward Dividend & Yield1.40 (2.54%)
Ex-Dividend DateFeb 27, 2020
1y Target Est55.27
  • INSIGHT-Scientists hunt pandemic hotspots in race to test vaccines
    Reuters

    INSIGHT-Scientists hunt pandemic hotspots in race to test vaccines

    The first wave of the COVID-19 pandemic may be waning. Scientists in Europe and the United States say the relative success of draconian lockdown and social distancing policies in some areas and countries means virus transmission rates may be at such low levels that there is not enough disease circulating to truly test potential vaccines.

  • Lilly's Cyramza Gets FDA Approval for First-Line Lung Cancer
    Zacks

    Lilly's Cyramza Gets FDA Approval for First-Line Lung Cancer

    FDA approves Lilly's (LLY) Cyramza as a combination regimen for metastatic EGFR-mutated non-small cell lung cancer. Cyramza is now approved for six indications to treat four different types of cancers.

  • Cancer Summit Presses Toward Treatments in Covid’s Shadow
    Bloomberg

    Cancer Summit Presses Toward Treatments in Covid’s Shadow

    (Bloomberg) -- The year’s biggest meeting of cancer researchers was subjected to a coronavirus overhaul this year, but even in scaled-back form it forced investors to recalibrate their expectations for some closely watched medicines.The American Society of Clinical Oncology meeting is the field’s most important gathering each spring, providing a stage for major pharmaceutical companies to unveil major findings and tout promising treatments. It’s also an annual opportunity for all kinds of researchers, doctors, executives and investors to rub elbows.With Covid-19 making travel uncomfortable and splashy conferences impossible this year, the summit was mostly a virtual affair. Still, it delivered many of the kinds of important victories and stinging setbacks it often does. And the meeting showed that even as the drug industry races to identify virus treatments and vaccines, cancer remains perhaps its most important business overall.“When the coronavirus wanes and we have a vaccine, and this infectious disease is brought under control, we will still have cancer and the need for new treatments,” said Richard Schilsky, ASCO’s chief medical officer, in an interview. “We have millions of patients around the world who need new and improved treatments for cancer.”Among the most noteworthy winners was U.K. pharmaceutical giant AstraZeneca Plc, which reported that its blockbuster Tagrisso reduced the risk of dying from lung cancer or relapse by four-fifths over three years. The drug is already AstraZeneca’s biggest product, bringing in $982 million in sales in the first quarter alone.Some smaller drug companies also logged what looked like significant victories: Trillium Therapeutics Inc. said that a second patient taking its experimental lymphoma therapy responded to the treatment. Shares of Trillium, which has a market value of about $560 million, surged more than 17% on FridayAnd as ASCO played out, other big cancer-research news also roiled drugmaker stocks.Pfizer Inc. shares fell 5.1% in trading before U.S. exchanges opened Monday after the U.S. drug bellwether said a late-stage study of its treatment for metastatic breast cancer, Ibrance, was unlikely to show a statistically significant improvement in invasive disease-free survival for patients with early breast cancer.Though the Covid-19 pandemic has been the defining story of the health-care business this year, the ASCO meeting was a reminder that most of the world’s pharmaceutical companies remain keenly focused on finding new cancer treatments to generate profits. And that focus has paid off for patients: The U.S. death rate from cancer has been falling at a record pace, thanks largely to big advances in treating lung tumors.Data presented at the meeting showed progress in combating the second leading cause of death worldwide, Schilsky said. Researchers found medicines used for patients with advanced disease can have an even bigger benefit for those with recently diagnosed tumors, while medicines are emerging that are effective against a wide range of tumors that are driven by specific gene mutations.Deals Getting DoneLarge drugmakers have remained on the prowl for promising cancer therapies that they can acquire through mergers or other transactions. Even Gilead Sciences Inc., which has been in the headlines because of its potential coronavirus treatment remdesivir, has been getting cancer-focused deals done against the backdrop of the pandemic.Last week, Gilead agreed to work on immunotherapy drugs with biotech Arcus Biosciences Inc. And earlier this year it agreed to buy cancer-drug maker Forty Seven for $4.9 billion. Gilead has been pressured by investors to find new drugs that can take the place of some of its aging blockbusters. It made another big bet on cancer when it bought Kite Pharma and its drug Yescarta, though sales of the highly priced genetic therapy have so far failed to live up to expectations.At ASCO, Gilead presented encouraging new data on magrolimab, an immunology drug that was developed by Forty Seven, a sign that the company’s wager could pay off. Gilead’s management is successfully building a pipeline of potential new therapies, Jefferies & Co. analyst Michael Yee said in a note sent to clients.Gilead shares dropped 1.5% early Monday. They now have gained about 20% so far this year, in part because of excitement over remdesivir.Breakthroughs at ASCO could make smaller companies enticing to Gilead and to other giants looking to add to their rosters of experimental therapies. Adaptimmune Therapeutics Plc’s U.S.-traded shares more than doubled in value after the company presented early studies for therapies that could treat a number of cancers, including lung and head and neck tumors.Allogene Therapeutics Inc., which is developing a CAR-T therapy similar to Yescarta, gained 3.5% Friday after it said its treatment benefited 63% of patients with blood cancer in an early-stage trial. Allogene’s founders ran Kite Pharma before selling it to Gilead for $11 billion in 2017.Dueling GiantsLike Gilead, Bristol-Myers Squibb Co. has also sought to refashion itself into a cancer-fighting juggernaut, mostly notably with its $74 billion takeover of Celgene Corp. last year. Even before that transaction, the company was locked in a battle with rival Merck & Co. for supremacy in the market for lung-cancer immunotherapies.Merck’s Keytruda and Bristol-Myers’s Opdivo are blockbusters for each company, and the drugmakers have raced to expand their use in a range of tumor types. But at ASCO, a study of Opdivo in combination with another Bristol-Myers drug, Yervoy, supported what JPMorgan Chase & Co. analyst Chris Schott said in a note was a “niche role” in treating certain lung-cancer patients -- not one that will upset Keytruda’s dominance.Bristol-Myers shares declined 0.2% on Friday, while Merck advanced 2.1%. Both were little changed before U.S. markets opened Monday.Last year, Opdivo generated $7.2 billion in revenue for Bristol-Myers, while Yervoy brought in $1.5 billion. Together, the two drugs accounted for roughly a third of the company’s sales. Meanwhile, Keytruda generated $11 billion for Merck, about 24% of its sales.Another challenge to Keytruda may come from Switzerland’s cancer titan Roche Holding AG. The drugmaker presented data at ASCO showing that combining the experimental tiragolumab with one of its proven medicines, Tecentriq, worked better than prescribing Tecentriq alone in patients with metastatic non-small-cell lung cancer. The phase 2 data suggests it “could potentially compete with Merck’s Keytruda in a segment of lung-cancer patients,” wrote Cinney Zhang of Bloomberg Intelligence.Some Chinese drugmakers also showed promising findings in liver cancer. A combination from Innovent Biologics Inc. showed initial efficacy comparable to Roche in hepatocellular carcinoma, for which China accounts for almost than half of new cases. Innovent shares surged 10% in Hong Kong trading Monday.(Updates with share moves for Pfizer, Gilead and Innovent in eighth, 14th and last paragraphs)For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.©2020 Bloomberg L.P.

  • GuruFocus.com

    AstraZeneca Ranked Most Inventive, Roche Most Innovative

    AbbVie was 2 in innovation for the second consecutive year and 7 in invention Continue reading...

  • Don’t Only Bet on Fast Vaccines, Root for Covid Treatments
    Bloomberg

    Don’t Only Bet on Fast Vaccines, Root for Covid Treatments

    (Bloomberg Opinion) -- As companies and countries pour money into the effort to develop Covid-19 vaccines, timelines keep getting more ambitious and dates for delivering a workable immunization against the virus keep moving up. Yet even with companies such as Moderna Therapeutics Inc. and AstraZeneca Plc signaling rapid progress and already enrolling patients in mid-stage trials, it would be quite a feat if we had a stockpile of proven doses by year's end. That’s a best-case scenario. A longer wait is more likely, and that may seem discouraging. The good news is, there is a batch of treatments in development with a chance of accelerated approval, and they can provide needed relief in the interim.Dozens of approaches could serve as a valuable bridge, from repurposed drugs to bespoke antibody cocktails. None can replace the value of a vaccine in getting the world back to normal, but the availability of more treatment options for sick patients could help to increase the chances of a faster and fuller recovery, and reduce the lethality of the disease. Two of the most familiar treatments options — the malaria drug hydroxychloroquine and Gilead Sciences Inc.’s remdesivir — have recently run into issues over safety and degree of efficacy, but there are plenty more in the pipeline.When it comes to development, the pathway for treatments is generally smoother than the one for vaccines, which can run into bottlenecks that are fundamentally difficult to break. For one, the fact that innoculations are aimed at healthy individuals means there is a higher safety bar. And the large trials necessary for trying out vaccines would have to occur in places where Covid-19 is spreading substantially to get the random exposure required to test them properly. With multiple candidates in development and ongoing precautions to avoid infection, getting robust data fast may be an issue. Finding volunteers is also an issue for treatment trials, as case counts level off. Still, many outcomes for infected patients can be determined comparatively rapidly. Along with a higher tolerance for side effects in individuals at possible near-term risk of dying, this permits smaller and faster tests.There are a few significant groups of possible treatments. The first involves repurposing existing drugs such as hydroxychloroquine and remdesivir. Because these types of medicines were originally designed to treat other conditions, they are less likely to produce a dramatic effect. However, if one is useful, it can be deployed quickly.One category within this group doesn't aim at the virus, but the out-of-control immune response it can cause. Roche Holding AG's arthritis drug Actemra has shown some early promise and is in larger trials. Researchers plan to test a variety of other medicines that target inflammation. If successful, they could provide several avenues to improved outcomes in critically ill patients. Another idea? Drug cocktails. That's the thought behind a recently started trial combining remdesivir and Actemra. Several other repurposed combinations, existing flu drugs, and a host of other medicines have opportunities to prove their worth.A second category of drug treatments involves a different type of recycling: using the blood of recovered individuals. People who survive Covid-19 develop antibodies against the virus and their donated plasma is already part of treatment regimens for sick patients around the world. Early results look promising, but they need confirmation from randomized trials that are now under way. Scale and variability issues may prevent convalescent plasma from treating millions, so it's worth boosting identification and collection efforts now even if the benefits of this type of treatment aren’t yet fully determined. A concentrated version under development by Takeda Pharmaceutical Co. also could prove useful.A related third group of medicines centers on artificially produced antibodies, which could be more effective and available than natural counterparts. Companies including Eli Lilly & Co., Regeneron Pharmaceuticals Inc. and Vir Biotechnology Inc. are pursuing this approach. Lilly announced the start of its first trial Monday. Regeneron, which created a successful antibody cocktail for an Ebola epidemic, is right behind. While there's no guarantee of success, these treatments have a better chance of autumn availability than even the fastest vaccines. It would take additional trials to confirm, but this category has particular value as a bridge because it can function as both treatment and temporary protection.Unless making and deploying hundreds of millions of inoculations is a lot easier than I expect and the fastest vaccines durably prevent both infection and transmission — a big ask for warp-speed efforts — Covid-19 may be around in diminished form for a while to come. That means treatments will remain valuable even after vaccines arrive. The more tools doctors have, the better.This column does not necessarily reflect the opinion of the editorial board or Bloomberg LP and its owners.Max Nisen is a Bloomberg Opinion columnist covering biotech, pharma and health care. He previously wrote about management and corporate strategy for Quartz and Business Insider.For more articles like this, please visit us at bloomberg.com/opinionSubscribe now to stay ahead with the most trusted business news source.©2020 Bloomberg L.P.

  • AstraZeneca scores twin drug approvals alongside vaccine progress
    Reuters Videos

    AstraZeneca scores twin drug approvals alongside vaccine progress

    AstraZeneca, now the most valuable London-listed company, has received international attention thanks to its hot pursuit of a coronavirus vaccine. It sealed U.S. government funding last month and aims to produce a billion doses this and next year. But while the recent buzz around the British firm has focused on a vaccine, cancer and heart medications are still its core business. On Monday (June 1) AstraZeneca clinched expanded regulatory backing for two medications, including one for major cancer treatment Lynparza. A panel of the European health regulator gave it the go ahead for use on a form of advanced pancreatic cancer. Also on Monday, the company got a green light from the U.S. for a heart medication. Meanwhile, AstraZeneca's covid vaccine manufacturing partner Oxford Biomedica last week signed a one-year deal with with the drugs firm. The vaccine has been developed by researchers at the University of Oxford and licensed to AstraZeneca. It's currently being tested on humans. The drugmaker is in talks with governments and global partners over its efforts to boost production. AstraZeneca shares were up 1% in afternoon trade.

  • Reuters

    U.S. awards new $628 mln contract to boost output of potential COVID-19 vaccine

    The U.S. government on Monday entered into a $628 million contract with drugmaker Emergent BioSolutions to boost manufacturing capacity for a potential COVID-19 vaccine. As drugmakers race to develop vaccines, tests and therapies for COVID-19, the United States is looking to secure manufacturing capacity under its "Operation Warp Speed" program announced in May to accelerate vaccine development. "Securing more manufacturing capacity here in America for candidates that make it to the final stages of Operation Warp Speed will help get a vaccine to American patients without a day wasted," Department of Health and Human Services (HHS) Secretary Alex Azar said in a statement.

  • BRILINTA Approved in the US to Reduce the Risk of a First Heart Attack or Stroke in High-Risk Patients with Coronary Artery Disease
    Business Wire

    BRILINTA Approved in the US to Reduce the Risk of a First Heart Attack or Stroke in High-Risk Patients with Coronary Artery Disease

    AstraZeneca’s BRILINTA® (ticagrelor) has been approved in the US to reduce the risk of a first heart attack or stroke in high-risk patients with coronary artery disease (CAD), the most common type of heart disease.

  • Bristol-Myers Deserves Better Than a Single-Digit Multiple
    GuruFocus.com

    Bristol-Myers Deserves Better Than a Single-Digit Multiple

    The company produced expectation-beating results. The acquisition of Celgene has gone very well, but shares trade with a multiple of less than 10 times earnings Continue reading...

  • AstraZeneca Scored A 'Home Run' With Its Cancer Drug — And Shares Popped
    Investor's Business Daily

    AstraZeneca Scored A 'Home Run' With Its Cancer Drug — And Shares Popped

    AstraZeneca's lung cancer treatment, Tagrisso, hit a "home run amid high expectations," an analyst said Friday as AZN stock popped. Researchers tested Tagrisso use following surgery.

  • AstraZeneca's Blockbuster Lung Cancer Drug Has a Huge Sales Boost Ahead
    Motley Fool

    AstraZeneca's Blockbuster Lung Cancer Drug Has a Huge Sales Boost Ahead

    Recently reported clinical trial data on Tagrisso shows that it lowers the risk of disease recurrence or death by 83% for some classes of lung cancer patients.

  • TheStreet.com

    AstraZeneca Reports Progress With Lung Cancer Drug

    AstraZeneca says its Tagrisso drug cut by 83% the risk of disease recurrence or death in patients with forms of early-stage non-small-cell lung cancer.

  • Barrons.com

    AstraZeneca Stock Jumps on Strong Cancer Drug Data

    The new data shows drug Tagrisso cut by 83% the risk of disease recurrence or death in patients with forms of early-stage non-small cell lung cancer.

  • Barrons.com

    The Dow Is Edging Down. Salesforce.com Falls as AstraZeneca Rises.

    Stocks inched lower as investors worried about increased tensions between Washington and Beijing, focusing on what President Donald Trump might say in a news conference on China planned for Friday.

  • IMFINZI® (durvalumab) Showed a Sustained Overall Survival Benefit in 1st-Line Extensive-Stage Small Cell Lung Cancer in the Phase III CASPIAN Trial
    Business Wire

    IMFINZI® (durvalumab) Showed a Sustained Overall Survival Benefit in 1st-Line Extensive-Stage Small Cell Lung Cancer in the Phase III CASPIAN Trial

    Detailed results from an updated analysis of the Phase III CASPIAN trial showed AstraZeneca’s IMFINZI in combination with a choice of chemotherapies, etoposide plus either carboplatin or cisplatin, demonstrated a sustained, clinically meaningful overall survival (OS) benefit for adults with extensive-stage small cell lung cancer (ES-SCLC) treated in the 1st-line setting.

  • ENHERTU (fam-trastuzumab deruxtecan-nxki) Significantly Improved Tumor Response Rate and Overall Survival in HER2-positive Metastatic Gastric Cancer in Phase II DESTINY-Gastric01 Trial
    Business Wire

    ENHERTU (fam-trastuzumab deruxtecan-nxki) Significantly Improved Tumor Response Rate and Overall Survival in HER2-positive Metastatic Gastric Cancer in Phase II DESTINY-Gastric01 Trial

    Detailed results from the positive registrational, randomized controlled Phase II DESTINY-Gastric01 trial showed AstraZeneca and Daiichi Sankyo Company, Limited’s (Daiichi Sankyo) ENHERTU® (fam-trastuzumab deruxtecan-nxki) demonstrated a statistically significant and clinically meaningful improvement in objective response rate (ORR) and overall survival (OS), a key secondary endpoint, versus chemotherapy.

  • ENHERTU (fam-trastuzumab deruxtecan-nxki) Demonstrated Meaningful Clinical Activity in Patients With HER2-mutant Non-small Cell Lung Cancer in Interim Analysis of Phase II DESTINY-Lung01 Trial
    Business Wire

    ENHERTU (fam-trastuzumab deruxtecan-nxki) Demonstrated Meaningful Clinical Activity in Patients With HER2-mutant Non-small Cell Lung Cancer in Interim Analysis of Phase II DESTINY-Lung01 Trial

    Results from the ongoing Phase II DESTINY-Lung01 trial showed AstraZeneca and Daiichi Sankyo Company, Limited’s (Daiichi Sankyo) ENHERTU® (fam-trastuzumab deruxtecan-nxki) achieved a clinically meaningful tumor response in patients with HER2-mutant (HER2m) unresectable and/or metastatic non-squamous non-small cell lung cancer (NSCLC) whose disease had progressed following one or more systemic therapies.

  • ENHERTU (fam-trastuzumab deruxtecan-nxki) Achieved a Tumor Response Rate of 45.3% in Patients With HER2-Positive Metastatic Colorectal Cancer in Phase II DESTINY-CRC01
    Business Wire

    ENHERTU (fam-trastuzumab deruxtecan-nxki) Achieved a Tumor Response Rate of 45.3% in Patients With HER2-Positive Metastatic Colorectal Cancer in Phase II DESTINY-CRC01

    Results from the ongoing Phase II DESTINY-CRC01 trial showed AstraZeneca and Daiichi Sankyo Company, Limited’s (Daiichi Sankyo) ENHERTU® (fam-trastuzumab deruxtecan-nxki) demonstrated clinically meaningful activity in patients with HER2-positive unresectable and/or metastatic colorectal cancer who received at least two prior lines of standard treatment.

  • AstraZeneca Unveils Data Behind New Win For Blockbuster Drug
    Bloomberg

    AstraZeneca Unveils Data Behind New Win For Blockbuster Drug

    (Bloomberg) -- AstraZeneca Plc’s blockbuster drug Tagrisso cut the risk of lung cancer death or relapse by four-fifths over three years, according to detailed results from a study that raises survival prospects for patients in the early stages of the deadly disease.Adding Tagrisso to the regimen of early-stage lung cancer patients who had undergone surgery reduced the risk of dying or disease recurrence by 79%, compared with a placebo, according to the research. Patients’ tumors also had a mutation in a cancer-linked gene, called EGFR. AstraZeneca will present the results at the American Society of Clinical Oncology’s annual conference on Sunday, a month and a half after the trial was halted early because of its strong outcome.Tagrisso is Astra’s biggest product, with sales of $982 million in the first quarter of this year. Around 60,000 additional patients may be eligible for treatment if the drug is approved in early-stage, post-surgical lung cancer, according to Dave Fredrickson, vice president for global oncology. Patients would take the drug for two to three years.The study results’ strength suggest that most doctors will adopt the therapy now as the standard of care for this new set of patients, rather than waiting for additional data on overall survival, Sam Fazeli, a Bloomberg Intelligence analyst, said in a note.AstraZeneca jumped as much as 3.4% in early London trading on Friday. Shares of the Cambridge, England-based company have gained about 50% in the past year.The most important implication of the trial is that it provides a “reason for more early screening to take place for lung cancer patients,” Fredrickson said in an interview. “The improved outcome that we’re seeking is cure.”Early screening often doesn’t take place currently because there are few therapies available compared with those for late-stage lung cancer, he said.After two years of treatment, 89% of patients in the trial treated with Tagrisso remained alive and disease-free, compared with 53% on placebo, Astra said. The results were consistent, whether patients got chemotherapy along with surgery or not.The ASCO conference is a key event in the calendar of oncology researchers and physicians, with scientists showcasing their best work and unveiling results from high-profile trials. This year’s meeting will be online due to the pandemic, with access to all results from the gathering available starting on Friday.(Updates with analyst’s comment in fourth paragraph.)For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.©2020 Bloomberg L.P.

  • GlobeNewswire

    Chi-Med Announces NDA Acceptance in China for Savolitinib in the Treatment of Non-Small Cell Lung Cancer with MET Exon 14 Skipping Mutations

    — First NDA filing of savolitinib globally — —  Chi-Med seeking first-in-class Chinese marketing authorization for a selective MET inhibitor — LONDON, May 29, 2020 --.

  • Financial Times

    A selection of the FT’s biggest stories and best reads every Friday

    Hello from Hong Kong, where the protests that went quiet during the coronavirus pandemic have come roaring back. Images of police officers rounding up children in school uniforms have added to the sense of shock following China’s announcement that it would impose national security legislation here. In response, the US has declared that Hong Kong is no longer autonomous and the UK has opened a path to citizenship for more than 300,000 Hong Kong residents.