| 26.51% | % of Shares Held by All Insider |
| 74.96% | % of Shares Held by Institutions |
| 102.00% | % of Float Held by Institutions |
| 182 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 4,785,500 | Jun 29, 2019 | 14.64% | 129,926,325 |
| BAMCO Inc. | 4,144,001 | Jun 29, 2019 | 12.67% | 112,509,627 |
| Blackrock Inc. | 2,900,191 | Jun 29, 2019 | 8.87% | 78,740,185 |
| Vanguard Group, Inc. (The) | 2,459,483 | Jun 29, 2019 | 7.52% | 66,774,963 |
| Frontier Capital Management Company LLC | 2,096,873 | Jun 29, 2019 | 6.41% | 56,930,101 |
| Artisan Partners Limited Partnership | 1,184,261 | Jun 29, 2019 | 3.62% | 32,152,686 |
| ArrowMark Colorado Holdings LLC | 1,005,734 | Jun 29, 2019 | 3.08% | 27,305,678 |
| Credit Suisse Ag/ | 954,417 | Jun 29, 2019 | 2.92% | 25,912,421 |
| Baillie Gifford and Company | 860,147 | Jun 29, 2019 | 2.63% | 23,352,991 |
| State Street Corporation | 797,767 | Jun 29, 2019 | 2.44% | 21,659,374 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Baron Growth Fund | 2,200,000 | Dec 30, 2018 | 6.73% | 100,584,000 |
| Fidelity Select Portfolios - Health Care | 1,500,000 | Jun 29, 2019 | 4.59% | 40,725,000 |
| Fidelity Select Portfolios - Medical Technology & Devices Port | 1,290,000 | Jun 29, 2019 | 3.95% | 35,023,500 |
| Fidelity Advisor Health Care Fund | 800,000 | Jun 29, 2019 | 2.45% | 21,720,000 |
| Baron Partners Fund | 774,629 | Dec 30, 2018 | 2.37% | 35,416,037 |
| Artisan Small Cap Fund | 678,000 | Dec 30, 2018 | 2.07% | 30,998,160 |
| iShares Russell 2000 ETF | 617,940 | Jun 29, 2019 | 1.89% | 16,777,071 |
| Vanguard Total Stock Market Index Fund | 518,045 | Dec 30, 2018 | 1.58% | 23,685,017 |
| Vanguard Small-Cap Index Fund | 491,594 | Dec 30, 2018 | 1.50% | 22,475,677 |
| Vanguard Extended Market Index Fund | 321,408 | Dec 30, 2018 | 0.98% | 14,694,773 |