| 1.45% | % of Shares Held by All Insider |
| 95.00% | % of Shares Held by Institutions |
| 96.40% | % of Float Held by Institutions |
| 238 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 6,592,556 | Dec 30, 2018 | 14.95% | 355,404,693 |
| Vanguard Group, Inc. (The) | 3,817,962 | Dec 30, 2018 | 8.66% | 205,826,331 |
| Blackrock Inc. | 3,445,991 | Dec 30, 2018 | 7.81% | 185,773,374 |
| Price (T.Rowe) Associates Inc | 3,022,107 | Dec 30, 2018 | 6.85% | 162,921,788 |
| Wellington Management Company, LLP | 2,631,859 | Dec 30, 2018 | 5.97% | 141,883,518 |
| Oppenheimer Funds, Inc. | 1,705,175 | Dec 30, 2018 | 3.87% | 91,925,984 |
| State Street Corporation | 1,535,024 | Dec 30, 2018 | 3.48% | 82,753,143 |
| Partner Fund Management, L.P. | 1,470,436 | Dec 30, 2018 | 3.33% | 79,271,204 |
| Hillhouse Capital Advisors Ltd. | 1,430,949 | Dec 30, 2018 | 3.24% | 77,142,460 |
| Viking Global Investors, L.P. | 1,200,322 | Dec 30, 2018 | 2.72% | 64,709,359 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Biotechnology | 1,569,611 | Feb 27, 2019 | 3.56% | 129,006,328 |
| Vanguard Small-Cap Index Fund | 1,065,644 | Sep 29, 2018 | 2.42% | 83,184,170 |
| Vanguard Total Stock Market Index Fund | 1,056,465 | Sep 29, 2018 | 2.40% | 82,467,657 |
| Oppenheimer Global Fund | 881,833 | Sep 29, 2018 | 2.00% | 68,835,883 |
| iShares Russell 2000 ETF | 873,026 | Feb 27, 2019 | 1.98% | 71,754,006 |
| Fidelity Select Portfolios - Health Care | 804,300 | Feb 27, 2019 | 1.82% | 66,105,417 |
| Price (T.Rowe) Health Sciences Fund | 797,842 | Dec 30, 2018 | 1.81% | 43,011,662 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 714,424 | Feb 27, 2019 | 1.62% | 58,718,508 |
| Vanguard Small Cap Value Index Fund | 658,558 | Sep 29, 2018 | 1.49% | 51,407,037 |
| Price (T.Rowe) New Horizons Fund | 634,903 | Dec 30, 2018 | 1.44% | 34,227,620 |