| 1.45% | % of Shares Held by All Insider |
| 95.00% | % of Shares Held by Institutions |
| 96.40% | % of Float Held by Institutions |
| 238 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 6,939,294 | Mar 30, 2019 | 14.20% | 555,490,484 |
| Vanguard Group, Inc. (The) | 3,959,505 | Mar 30, 2019 | 8.10% | 316,958,375 |
| Blackrock Inc. | 3,399,075 | Mar 30, 2019 | 6.96% | 272,095,953 |
| Price (T.Rowe) Associates Inc | 3,375,609 | Mar 30, 2019 | 6.91% | 270,217,500 |
| Wellington Management Company, LLP | 2,537,439 | Mar 30, 2019 | 5.19% | 203,121,991 |
| Oppenheimer Funds, Inc. | 1,710,895 | Mar 30, 2019 | 3.50% | 136,957,144 |
| Hillhouse Capital Advisors Ltd. | 1,498,516 | Mar 30, 2019 | 3.07% | 119,956,205 |
| State Street Corporation | 1,335,649 | Mar 30, 2019 | 2.73% | 106,918,702 |
| Perceptive Advisors Llc | 1,271,054 | Mar 30, 2019 | 2.60% | 101,747,872 |
| AllianceBernstein, L.P. | 992,129 | Mar 30, 2019 | 2.03% | 79,419,926 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Biotechnology | 1,475,211 | May 30, 2019 | 3.02% | 112,116,036 |
| Vanguard Total Stock Market Index Fund | 1,112,494 | Dec 30, 2018 | 2.28% | 59,974,551 |
| Vanguard Small-Cap Index Fund | 1,070,089 | Dec 30, 2018 | 2.19% | 57,688,497 |
| Invesco Oppenheimer Global Fund | 920,923 | Dec 30, 2018 | 1.89% | 49,646,958 |
| iShares Russell 2000 ETF | 912,486 | May 30, 2019 | 1.87% | 69,348,936 |
| Price (T.Rowe) New Horizons Fund | 870,913 | Mar 30, 2019 | 1.78% | 69,716,585 |
| Fidelity Select Portfolios - Health Care | 800,000 | May 30, 2019 | 1.64% | 60,800,000 |
| Price (T.Rowe) Health Sciences Fund | 796,262 | Mar 30, 2019 | 1.63% | 63,740,773 |
| Vanguard Extended Market Index Fund | 603,031 | Dec 30, 2018 | 1.23% | 32,509,401 |
| Carillon Ser Tr-Carillon Eagle Small Cap Growth Fund | 566,166 | Mar 30, 2019 | 1.16% | 45,321,588 |