| 34.73% | % of Shares Held by All Insider |
| 52.96% | % of Shares Held by Institutions |
| 81.13% | % of Float Held by Institutions |
| 151 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 5,663,196 | Jun 29, 2019 | 9.76% | 52,667,722 |
| Blackrock Inc. | 3,852,875 | Jun 29, 2019 | 6.64% | 35,831,737 |
| Wasatch Advisors Inc | 3,004,865 | Jun 29, 2019 | 5.18% | 27,945,244 |
| Cormorant Asset Management, LP | 2,365,280 | Jun 29, 2019 | 4.07% | 21,997,104 |
| Farallon Capital Management LLC | 2,000,000 | Jun 29, 2019 | 3.45% | 18,600,000 |
| Carmignac Gestion | 1,881,609 | Jun 29, 2019 | 3.24% | 17,498,963 |
| State Street Corporation | 1,799,564 | Jun 29, 2019 | 3.10% | 16,735,945 |
| Vanguard Group, Inc. (The) | 1,774,489 | Jun 29, 2019 | 3.06% | 16,502,747 |
| Consonance Capital Management LP | 1,666,667 | Jun 29, 2019 | 2.87% | 15,500,003 |
| Renaissance Technologies, LLC | 1,465,381 | Jun 29, 2019 | 2.52% | 13,628,043 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Growth Company Fund | 2,253,080 | Jun 29, 2019 | 3.88% | 20,953,644 |
| Fidelity Select Portfolios - Biotechnology | 1,092,532 | Jun 29, 2019 | 1.88% | 10,160,547 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,046,807 | Jun 29, 2019 | 1.80% | 9,735,305 |
| Wasatch Small Cap Growth Fund | 1,007,617 | Dec 30, 2018 | 1.74% | 10,993,101 |
| Vanguard Total Stock Market Index Fund | 859,605 | Dec 30, 2018 | 1.48% | 9,378,290 |
| iShares Russell 2000 ETF | 849,664 | Jun 29, 2019 | 1.46% | 7,901,875 |
| Fidelity Series Growth Company Fund | 615,700 | Jun 29, 2019 | 1.06% | 5,726,010 |
| iShares NASDAQ Biotechnology ETF | 578,382 | Jun 29, 2019 | 1.00% | 5,378,952 |
| Franklin Strategic Series-Franklin Biotechnology Discove | 528,108 | Jan 30, 2019 | 0.91% | 6,464,041 |
| iShares Russell 2000 Growth ETF | 359,605 | Jun 29, 2019 | 0.62% | 3,344,326 |