| 7.63% | % of Shares Held by All Insider |
| 55.70% | % of Shares Held by Institutions |
| 60.29% | % of Float Held by Institutions |
| 53 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fosun International Ltd | 7,453,857 | Mar 30, 2019 | 9.39% | 2,964,398 |
| Oracle Investment Management Inc | 5,621,199 | Mar 30, 2019 | 7.08% | 2,235,550 |
| Baker Brothers Advisors, LLC | 2,914,536 | Mar 30, 2019 | 3.67% | 1,159,110 |
| Vanguard Group, Inc. (The) | 2,888,433 | Mar 30, 2019 | 3.64% | 1,148,729 |
| Adage Capital Partners GP L.L.C. | 2,880,000 | Mar 30, 2019 | 3.63% | 1,145,376 |
| 683 Capital Management LLC | 2,500,000 | Mar 30, 2019 | 3.15% | 994,250 |
| BVF Inc. | 1,898,990 | Mar 30, 2019 | 2.39% | 755,228 |
| White Pine Capital, LLC | 907,430 | Mar 30, 2019 | 1.14% | 360,884 |
| Lombard Odier Asset Management (USA) Corp | 500,000 | Mar 30, 2019 | 0.63% | 198,850 |
| Geode Capital Management, LLC | 377,908 | Mar 30, 2019 | 0.48% | 150,294 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 1,678,529 | Dec 30, 2018 | 2.11% | 2,568,149 |
| Vanguard Extended Market Index Fund | 958,686 | Dec 30, 2018 | 1.21% | 1,466,789 |
| Fidelity Extended Market Index Fund | 293,502 | Apr 29, 2019 | 0.37% | 150,273 |
| iShares Micro Cap ETF | 148,957 | Apr 29, 2019 | 0.19% | 76,265 |
| Fidelity NASDAQ Composite Index Fund | 97,445 | Apr 29, 2019 | 0.12% | 49,891 |
| Fidelity Total Market Index Fund | 88,575 | Apr 29, 2019 | 0.11% | 45,350 |
| Vanguard Institutional Index-Inst Total Stock Market Ind | 76,434 | Dec 30, 2018 | 0.10% | 116,944 |
| Vanguard Balanced Index Fund | 40,456 | Dec 30, 2018 | 0.05% | 61,897 |
| USAA Mutual Fd Tr-Extended Market Index Fd | 15,199 | Dec 30, 2018 | 0.02% | 23,254 |
| EQ Advisors Trust-1290 VT Micro Cap Port | 12,690 | Dec 30, 2018 | 0.02% | 19,415 |