| 3.54% | % of Shares Held by All Insider |
| 97.45% | % of Shares Held by Institutions |
| 101.03% | % of Float Held by Institutions |
| 172 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Wellington Management Company, LLP | 7,416,879 | Mar 30, 2019 | 10.70% | 101,166,229 |
| Temasek Holdings (Private) Limited | 6,556,116 | Mar 30, 2019 | 9.46% | 89,425,422 |
| JP Morgan Chase & Company | 4,742,589 | Mar 30, 2019 | 6.84% | 64,688,913 |
| Blackrock Inc. | 4,553,890 | Mar 30, 2019 | 6.57% | 62,115,059 |
| FMR, LLC | 4,127,334 | Mar 30, 2019 | 5.95% | 56,296,835 |
| Kohlberg Kravis Roberts & Co. L.P. | 3,055,055 | Mar 30, 2019 | 4.41% | 41,670,950 |
| Vanguard Group, Inc. (The) | 2,871,492 | Mar 30, 2019 | 4.14% | 39,167,150 |
| Sofinnova Investments, Inc. | 2,868,221 | Mar 30, 2019 | 4.14% | 39,122,534 |
| Rubric Capital Management LP | 2,640,771 | Mar 30, 2019 | 3.81% | 36,020,116 |
| Citadel Advisors LLC | 2,511,982 | Mar 30, 2019 | 3.62% | 34,263,434 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| JP Morgan Small Cap Growth Fund | 1,598,617 | Apr 29, 2019 | 2.31% | 25,449,982 |
| Vanguard Total Stock Market Index Fund | 1,486,189 | Dec 30, 2018 | 2.14% | 13,450,010 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,234,417 | Apr 29, 2019 | 1.78% | 19,651,918 |
| Fidelity Growth Company Fund | 1,098,743 | Apr 29, 2019 | 1.58% | 17,491,988 |
| iShares Russell 2000 ETF | 1,078,747 | Apr 29, 2019 | 1.56% | 17,173,652 |
| College Retirement Equities Fund-Stock Account | 1,070,170 | Sep 29, 2018 | 1.54% | 17,657,805 |
| Hartford Healthcare Fund | 928,526 | Oct 30, 2018 | 1.34% | 10,854,468 |
| Vanguard Extended Market Index Fund | 798,586 | Dec 30, 2018 | 1.15% | 7,227,203 |
| iShares NASDAQ Biotechnology ETF | 718,518 | Apr 29, 2019 | 1.04% | 11,438,806 |
| TIAA-CREF Funds-Mid-Cap Growth Fund | 608,023 | Oct 30, 2018 | 0.88% | 7,107,788 |