| 3.54% | % of Shares Held by All Insider |
| 97.45% | % of Shares Held by Institutions |
| 101.03% | % of Float Held by Institutions |
| 172 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Wellington Management Company, LLP | 7,663,457 | Dec 30, 2018 | 11.05% | 69,354,285 |
| Temasek Holdings (Private) Limited | 6,556,116 | Dec 30, 2018 | 9.46% | 59,332,849 |
| Blackrock Inc. | 4,722,418 | Dec 30, 2018 | 6.81% | 42,737,882 |
| FMR, LLC | 4,580,230 | Dec 30, 2018 | 6.61% | 41,451,081 |
| JP Morgan Chase & Company | 3,731,881 | Dec 30, 2018 | 5.38% | 33,773,523 |
| Kohlberg Kravis Roberts & Co. L.P. | 3,055,055 | Dec 30, 2018 | 4.41% | 27,648,247 |
| Rubric Capital Management LP | 3,050,000 | Dec 30, 2018 | 4.40% | 27,602,500 |
| Sofinnova Investments, Inc. | 2,868,221 | Dec 30, 2018 | 4.14% | 25,957,400 |
| Vanguard Group, Inc. (The) | 2,766,112 | Dec 30, 2018 | 3.99% | 25,033,313 |
| State Street Corporation | 2,644,123 | Dec 30, 2018 | 3.81% | 23,929,313 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,740,794 | Feb 27, 2019 | 2.51% | 24,962,985 |
| JP Morgan Small Cap Growth Fund | 1,490,675 | Feb 27, 2019 | 2.15% | 21,376,279 |
| Vanguard Total Stock Market Index Fund | 1,458,133 | Sep 29, 2018 | 2.10% | 24,059,194 |
| Fidelity Growth Company Fund | 1,165,046 | Feb 27, 2019 | 1.68% | 16,706,759 |
| iShares Russell 2000 ETF | 1,106,467 | Feb 27, 2019 | 1.60% | 15,866,736 |
| College Retirement Equities Fund-Stock Account | 1,070,170 | Sep 29, 2018 | 1.54% | 17,657,805 |
| Hartford Healthcare Fund | 928,526 | Jul 30, 2018 | 1.34% | 17,688,420 |
| Vanguard Extended Market Index Fund | 770,912 | Sep 29, 2018 | 1.11% | 12,720,048 |
| iShares NASDAQ Biotechnology ETF | 738,900 | Feb 27, 2019 | 1.07% | 10,595,826 |
| TIAA-CREF Funds-Mid-Cap Growth Fund | 608,023 | Oct 30, 2018 | 0.88% | 7,107,788 |