| 3.54% | % of Shares Held by All Insider |
| 97.45% | % of Shares Held by Institutions |
| 101.03% | % of Float Held by Institutions |
| 172 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Wellington Management Company, LLP | 6,822,188 | Jun 29, 2019 | 9.78% | 150,770,354 |
| Temasek Holdings (Private) Limited | 6,556,116 | Jun 29, 2019 | 9.40% | 144,890,163 |
| Blackrock Inc. | 5,037,431 | Jun 29, 2019 | 7.22% | 111,327,225 |
| JP Morgan Chase & Company | 4,263,805 | Jun 29, 2019 | 6.11% | 94,230,090 |
| FMR, LLC | 3,372,527 | Jun 29, 2019 | 4.83% | 74,532,846 |
| Kohlberg Kravis Roberts & Co. L.P. | 3,055,055 | Jun 29, 2019 | 4.38% | 67,516,715 |
| Vanguard Group, Inc. (The) | 2,958,583 | Jun 29, 2019 | 4.24% | 65,384,684 |
| State Street Corporation | 2,440,954 | Jun 29, 2019 | 3.50% | 53,945,083 |
| Lord Abbett & Co | 2,414,338 | Jun 29, 2019 | 3.46% | 53,356,869 |
| Sofinnova Investments, Inc. | 2,093,221 | Jun 29, 2019 | 3.00% | 46,260,184 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 1,576,901 | Mar 30, 2019 | 2.26% | 21,508,929 |
| JP Morgan Small Cap Growth Fund | 1,433,102 | Jul 30, 2019 | 2.05% | 24,104,775 |
| iShares Russell 2000 ETF | 1,333,523 | Jul 30, 2019 | 1.91% | 22,429,856 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,187,583 | Jul 30, 2019 | 1.70% | 19,975,146 |
| Fidelity Growth Company Fund | 1,089,961 | Jul 30, 2019 | 1.56% | 18,333,144 |
| College Retirement Equities Fund-Stock Account | 1,074,967 | Dec 30, 2018 | 1.54% | 9,728,451 |
| Hartford Healthcare Fund | 842,151 | Jan 30, 2019 | 1.21% | 11,335,352 |
| Vanguard Extended Market Index Fund | 813,609 | Mar 30, 2019 | 1.17% | 11,097,626 |
| iShares NASDAQ Biotechnology ETF | 688,865 | Jul 30, 2019 | 0.99% | 11,586,709 |
| TIAA-CREF Funds-Mid-Cap Growth Fund | 625,223 | Jan 30, 2019 | 0.90% | 8,415,501 |