| 17.28% | % of Shares Held by All Insider |
| 24.15% | % of Shares Held by Institutions |
| 29.19% | % of Float Held by Institutions |
| 52 | Number of Institutions Holding Shares |
| Name | Shares | Date Reported |
|---|---|---|
| AURIGENE DISCOVERY TECHNOLOGIES LTD | 27,328,464 | Sep 6, 2016 |
| MCNAB JAMES R | 879,688 | Apr 25, 2017 |
| FATTAEY ALI PH.D. | 322,140 | Jan 21, 2018 |
| RUBIN MARC | 236,596 | Jan 21, 2018 |
| GREENACRE MARTYN D | 222,945 | Jan 21, 2018 |
| KAITIN KENNETH I | 214,607 | Jan 21, 2018 |
| DENTZER JAMES E | 212,011 | Jan 21, 2018 |
| MARTELL ROBERT | 185,000 | Jan 21, 2018 |
| TUCK DAVID | 169,424 | Jan 21, 2018 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,982,208 | Dec 30, 2018 | 9.00% | 2,057,127 |
| Vanguard Group, Inc. (The) | 995,327 | Dec 30, 2018 | 3.00% | 686,576 |
| Renaissance Technologies, LLC | 823,029 | Dec 30, 2018 | 2.48% | 567,725 |
| Arnhold, LLC | 494,980 | Dec 30, 2018 | 1.49% | 341,437 |
| First Eagle Investment Management, LLC | 448,547 | Dec 30, 2018 | 1.35% | 309,407 |
| Blackrock Inc. | 422,623 | Dec 30, 2018 | 1.27% | 291,525 |
| Geode Capital Management, LLC | 218,803 | Dec 30, 2018 | 0.66% | 150,930 |
| Oxford Asset Management Llp | 212,036 | Dec 30, 2018 | 0.64% | 146,262 |
| Fosun International Ltd | 201,086 | Dec 30, 2018 | 0.61% | 138,709 |
| Millennium Management LLC | 177,577 | Dec 30, 2018 | 0.54% | 122,492 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 673,049 | Sep 29, 2018 | 2.03% | 1,198,027 |
| Vanguard Extended Market Index Fund | 363,068 | Sep 29, 2018 | 1.10% | 646,261 |
| Bridgeway Funds Inc-Ultra Small Company Market Fund | 178,900 | Sep 29, 2018 | 0.54% | 318,442 |
| Fidelity Extended Market Index Fund | 112,824 | Feb 27, 2019 | 0.34% | 118,465 |
| Fidelity NASDAQ Composite Index Fund | 67,371 | Feb 27, 2019 | 0.20% | 70,739 |
| Vanguard Institutional Index-Inst Total Stock Market Ind | 37,775 | Sep 29, 2018 | 0.11% | 67,239 |
| Fidelity Total Market Index Fund | 35,800 | Feb 27, 2019 | 0.11% | 37,590 |
| iShares Core S&P Total U.S. Stock Market ETF | 13,293 | Feb 27, 2019 | 0.04% | 13,957 |
| Vanguard Balanced Index Fund | 6,695 | Sep 29, 2018 | 0.02% | 11,917 |
| Meeder Funds-Spectrum Fund | 5,388 | Sep 29, 2018 | 0.02% | 9,590 |