| 17.28% | % of Shares Held by All Insider |
| 24.15% | % of Shares Held by Institutions |
| 29.19% | % of Float Held by Institutions |
| 52 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,982,208 | Mar 30, 2019 | 9.00% | 5,934,593 |
| Vanguard Group, Inc. (The) | 1,312,327 | Mar 30, 2019 | 3.96% | 2,611,530 |
| Renaissance Technologies, LLC | 987,829 | Mar 30, 2019 | 2.98% | 1,965,779 |
| Arnhold, LLC | 425,338 | Mar 30, 2019 | 1.28% | 846,422 |
| Blackrock Inc. | 423,554 | Mar 30, 2019 | 1.28% | 842,872 |
| Fosun International Ltd | 396,869 | Mar 30, 2019 | 1.20% | 789,769 |
| Geode Capital Management, LLC | 218,128 | Mar 30, 2019 | 0.66% | 434,074 |
| Millennium Management LLC | 107,750 | Mar 30, 2019 | 0.33% | 214,422 |
| Northern Trust Corporation | 66,188 | Mar 30, 2019 | 0.20% | 131,714 |
| Bank Of New York Mellon Corporation | 64,301 | Mar 30, 2019 | 0.19% | 127,958 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 576,377 | Dec 30, 2018 | 1.74% | 397,584 |
| Vanguard Extended Market Index Fund | 363,068 | Dec 30, 2018 | 1.10% | 250,444 |
| Fidelity Extended Market Index Fund | 112,824 | Apr 29, 2019 | 0.34% | 212,109 |
| Fidelity NASDAQ Composite Index Fund | 67,371 | Apr 29, 2019 | 0.20% | 126,657 |
| Fidelity Total Market Index Fund | 59,119 | Apr 29, 2019 | 0.18% | 111,143 |
| Vanguard Institutional Index-Inst Total Stock Market Ind | 37,775 | Dec 30, 2018 | 0.11% | 26,057 |
| iShares Core S&P Total U.S. Stock Market ETF | 13,643 | Apr 29, 2019 | 0.04% | 25,648 |
| Vanguard Balanced Index Fund | 6,995 | Dec 30, 2018 | 0.02% | 4,825 |
| Meeder Funds-Spectrum Fund | 5,388 | Sep 29, 2018 | 0.02% | 9,590 |
| Blackstone Alternative Multi-Strategy Fund | 4,160 | Sep 29, 2018 | 0.01% | 7,404 |