| 17.28% | % of Shares Held by All Insider |
| 24.15% | % of Shares Held by Institutions |
| 29.19% | % of Float Held by Institutions |
| 52 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,982,208 | Jun 29, 2019 | 8.98% | 5,546,906 |
| Vanguard Group, Inc. (The) | 1,252,233 | Jun 29, 2019 | 3.77% | 2,329,153 |
| Renaissance Technologies, LLC | 1,191,419 | Jun 29, 2019 | 3.59% | 2,216,039 |
| Fosun International Ltd | 581,834 | Jun 29, 2019 | 1.75% | 1,082,211 |
| Blackrock Inc. | 487,816 | Jun 29, 2019 | 1.47% | 907,337 |
| Arnhold, LLC | 425,338 | Jun 29, 2019 | 1.28% | 791,128 |
| Geode Capital Management, LLC | 262,935 | Jun 29, 2019 | 0.79% | 489,059 |
| Bridgeway Capital Management, Inc. | 112,240 | Jun 29, 2019 | 0.34% | 208,766 |
| Bank Of New York Mellon Corporation | 64,304 | Jun 29, 2019 | 0.19% | 119,605 |
| Northern Trust Corporation | 62,188 | Jun 29, 2019 | 0.19% | 115,669 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 893,474 | Mar 30, 2019 | 2.69% | 1,778,013 |
| Vanguard Extended Market Index Fund | 363,068 | Mar 30, 2019 | 1.09% | 722,505 |
| Fidelity Extended Market Index Fund | 112,824 | Jun 29, 2019 | 0.34% | 209,852 |
| iShares Micro Cap ETF | 72,861 | Jul 30, 2019 | 0.22% | 165,394 |
| Fidelity NASDAQ Composite Index Fund | 67,371 | Jun 29, 2019 | 0.20% | 125,310 |
| Fidelity Total Market Index Fund | 59,119 | Jun 29, 2019 | 0.18% | 109,961 |
| Vanguard Institutional Index-Inst Total Stock Market Ind | 37,775 | Mar 30, 2019 | 0.11% | 75,172 |
| Fidelity Series Total Market Index Fund | 21,488 | Jun 29, 2019 | 0.06% | 39,967 |
| iShares Core S&P Total U.S. Stock Market ETF | 14,493 | Jul 30, 2019 | 0.04% | 32,899 |
| Vanguard Balanced Index Fund | 6,995 | Dec 30, 2018 | 0.02% | 4,825 |