| 0.76% | % of Shares Held by All Insider |
| 61.04% | % of Shares Held by Institutions |
| 61.51% | % of Float Held by Institutions |
| 94 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| BVF Inc. | 6,929,690 | Jun 29, 2019 | 11.95% | 5,954,682 |
| Orbimed Advisors LLC. | 5,000,000 | Jun 29, 2019 | 8.62% | 4,296,500 |
| Stonepine Capital Management, LLC | 3,904,400 | Jun 29, 2019 | 6.73% | 3,355,050 |
| NEA Management Company, LLC | 3,750,000 | Jun 29, 2019 | 6.47% | 3,222,375 |
| Renaissance Technologies, LLC | 1,596,587 | Jun 29, 2019 | 2.75% | 1,371,947 |
| Vanguard Group, Inc. (The) | 1,055,954 | Jun 29, 2019 | 1.82% | 907,381 |
| Millennium Management LLC | 689,551 | Jun 29, 2019 | 1.19% | 592,531 |
| Northern Trust Corporation | 538,290 | Jun 29, 2019 | 0.93% | 462,552 |
| Fosun International Ltd | 459,274 | Jun 29, 2019 | 0.79% | 394,654 |
| Geode Capital Management, LLC | 456,654 | Jun 29, 2019 | 0.79% | 392,402 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Extended Market Index Fund | 690,723 | Mar 30, 2019 | 1.19% | 670,139 |
| Vanguard Total Stock Market Index Fund | 512,401 | Mar 30, 2019 | 0.88% | 497,131 |
| Fidelity Extended Market Index Fund | 232,172 | Jun 29, 2019 | 0.40% | 199,505 |
| Fidelity Small Cap Index Fund | 189,439 | Apr 29, 2019 | 0.33% | 185,612 |
| Schwab Capital Trust-Small Cap Index Fund | 95,500 | Jan 30, 2019 | 0.16% | 113,645 |
| EQ Advisors Trust-Axa 2000 Managed Volatility Port | 76,320 | Dec 30, 2018 | 0.13% | 55,988 |
| Quantitative Master Series Tr-Master Small Cap Index Series | 72,383 | Dec 30, 2018 | 0.12% | 53,100 |
| College Retirement Equities Fund-Stock Account | 71,056 | Dec 30, 2018 | 0.12% | 52,126 |
| Vanguard Institutional Index-Inst Total Stock Market Ind | 70,123 | Mar 30, 2019 | 0.12% | 68,033 |
| Fidelity Total Market Index Fund | 69,610 | Jun 29, 2019 | 0.12% | 59,815 |