| 0.76% | % of Shares Held by All Insider |
| 61.04% | % of Shares Held by Institutions |
| 61.51% | % of Float Held by Institutions |
| 94 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| BVF Inc. | 6,929,690 | Mar 30, 2019 | 11.95% | 6,723,185 |
| Orbimed Advisors LLC. | 5,000,000 | Mar 30, 2019 | 8.62% | 4,851,000 |
| Stonepine Capital Management, LLC | 4,000,000 | Mar 30, 2019 | 6.90% | 3,880,800 |
| NEA Management Company, LLC | 3,750,000 | Mar 30, 2019 | 6.47% | 3,638,250 |
| Blackrock Inc. | 2,794,715 | Mar 30, 2019 | 4.82% | 2,711,432 |
| Vanguard Group, Inc. (The) | 1,504,296 | Mar 30, 2019 | 2.59% | 1,459,467 |
| Renaissance Technologies, LLC | 1,282,352 | Mar 30, 2019 | 2.21% | 1,244,137 |
| State Street Corporation | 958,865 | Mar 30, 2019 | 1.65% | 930,290 |
| Geode Capital Management, LLC | 631,113 | Mar 30, 2019 | 1.09% | 612,305 |
| Northern Trust Corporation | 567,723 | Mar 30, 2019 | 0.98% | 550,804 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| iShares Russell 2000 ETF | 1,035,233 | Apr 29, 2019 | 1.79% | 1,014,321 |
| Vanguard Extended Market Index Fund | 690,723 | Dec 30, 2018 | 1.19% | 506,714 |
| Vanguard Total Stock Market Index Fund | 512,182 | Dec 30, 2018 | 0.88% | 375,736 |
| iShares Russell 2000 Growth ETF | 444,594 | Apr 29, 2019 | 0.77% | 435,613 |
| Fidelity Extended Market Index Fund | 232,172 | Apr 29, 2019 | 0.40% | 227,482 |
| Fidelity Small Cap Index Fund | 184,781 | Jan 30, 2019 | 0.32% | 219,889 |
| iShares Micro Cap ETF | 125,324 | Apr 29, 2019 | 0.22% | 122,792 |
| Schwab Capital Trust-Small Cap Index Fund | 95,500 | Oct 30, 2018 | 0.16% | 164,260 |
| Alps ETF Tr-Alps Medical Breakthroughs ETF | 92,987 | Nov 29, 2018 | 0.16% | 156,218 |
| EQ Advisors Trust-Axa 2000 Managed Volatility Port | 76,320 | Dec 30, 2018 | 0.13% | 55,988 |