| 4.94% | % of Shares Held by All Insider |
| 93.24% | % of Shares Held by Institutions |
| 98.08% | % of Float Held by Institutions |
| 156 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Primecap Management Company | 10,253,801 | Mar 30, 2019 | 11.29% | 127,044,594 |
| Redmile Group, LLC | 7,694,020 | Mar 30, 2019 | 8.47% | 95,328,907 |
| Palo Alto Investors Lp | 6,935,074 | Mar 30, 2019 | 7.63% | 85,925,566 |
| NEA Management Company, LLC | 6,877,518 | Mar 30, 2019 | 7.57% | 85,212,448 |
| Vanguard Group, Inc. (The) | 5,448,299 | Mar 30, 2019 | 6.00% | 67,504,424 |
| Blackrock Inc. | 4,888,381 | Mar 30, 2019 | 5.38% | 60,567,040 |
| FMR, LLC | 3,484,137 | Mar 30, 2019 | 3.84% | 43,168,457 |
| Consonance Capital Management LP | 3,478,261 | Mar 30, 2019 | 3.83% | 43,095,653 |
| State Street Corporation | 2,285,444 | Mar 30, 2019 | 2.52% | 28,316,651 |
| Great Point Partners LLC | 2,173,913 | Mar 30, 2019 | 2.39% | 26,934,782 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Primecap Odyssey Aggressive Growth Fund | 6,113,784 | Mar 30, 2019 | 6.73% | 75,749,783 |
| Primecap Odyssey Growth Fund | 3,583,517 | Mar 30, 2019 | 3.95% | 44,399,775 |
| Fidelity Select Portfolios - Biotechnology | 2,837,946 | May 30, 2019 | 3.12% | 38,993,378 |
| Vanguard Small-Cap Index Fund | 1,534,255 | Dec 30, 2018 | 1.69% | 9,451,010 |
| iShares Russell 2000 ETF | 1,207,723 | May 30, 2019 | 1.33% | 16,594,114 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,091,918 | May 30, 2019 | 1.20% | 15,002,953 |
| iShares NASDAQ Biotechnology ETF | 924,859 | May 30, 2019 | 1.02% | 12,707,562 |
| Vanguard Extended Market Index Fund | 861,234 | Dec 30, 2018 | 0.95% | 5,305,201 |
| Vanguard Small-Cap Growth Index Fund | 860,463 | Dec 30, 2018 | 0.95% | 5,300,452 |
| iShares Russell 2000 Growth ETF | 373,905 | May 30, 2019 | 0.41% | 5,137,454 |