17.88 0.00 (0.00%)
After hours: 5:48PM EST
|Bid||17.88 x 4000|
|Ask||17.88 x 1400|
|Day's Range||17.45 - 18.10|
|52 Week Range||15.02 - 25.31|
|Beta (5Y Monthly)||1.72|
|PE Ratio (TTM)||9.14|
|Earnings Date||Feb 25, 2020|
|Forward Dividend & Yield||N/A (N/A)|
|1y Target Est||24.50|
With rents soaring in other Bay Area biotech hubs, Alameda is staking its claim as an industry hotspot. Three companies — cancer drug developer Exelixis Inc., medical device company Penumbra Inc. and the diabetes care unit of Abbott Laboratories — are expanding in the East Bay island city. "It's Alameda's time again," said Joe Ernst, principal and founder of srmErnst Development Partners.
Roche (RHHBY) submits sBLA for the label expansion of the Tecentriq-Avastin combo to treat HCC patients who have not received prior systemic therapy.
Exelixis, Inc. (NASDAQ: EXEL) today announced phase 1/2 clinical trial results from the combination of cabozantinib (CABOMETYX®) and nivolumab (Opdivo®) with or without ipilimumab (Yervoy®) in advanced hepatocellular carcinoma (HCC). Data from the cabozantinib combination cohort of the CheckMate 040 trial will be presented on Friday, January 24 during Rapid Abstract Session B from 7:00 – 7:45 a.m. PT at the 2020 American Society of Clinical Oncology’s Gastrointestinal Cancers Symposium (ASCO GI), which is being held in San Francisco, California, January 23-25, 2020. The data will also be included in Poster Session B from 12:00 – 1:30 p.m. PT and 4:30 – 5:30 p.m. PT on January 24.
The company had about $500M in debt 10 years ago and was down to 80 employees five years ago. Today it's debt-free, hiring and taking more space in Alameda.
Exelixis (EXEL) has an impressive earnings surprise history and currently possesses the right combination of the two key ingredients for a likely beat in its next quarterly report.
Exelixis, Inc. (Nasdaq: EXEL) today announced its key priorities and anticipated milestones for 2020-21, including generating top-line data from key clinical trials, completing enrollment of ongoing studies, initiating new pivotal trials, and progressing its mid-stage and early pipeline. The company intends to make appropriate investments to maximize the clinical development opportunities for CABOMETYX® (cabozantinib), which Exelixis believes could lead to as many as four additional approved indications by year-end 2021, while concurrently working to advance a pipeline of potential new Exelixis medicines through internal drug discovery and business development.
While the market driven by short-term sentiment influenced by the accomodative interest rate environment in the US, increasing oil prices and deteriorating expectations towards the resolution of the trade war with China, many smart money investors kept their cautious approach regarding the current bull run in the third quarter and hedging or reducing many of […]
Exelixis, Inc. (Nasdaq: EXEL) today announced that Michael M. Morrissey, Ph.D., the company’s President and Chief Executive Officer, will provide a corporate overview at the 38th Annual J.P. Morgan Healthcare Conference being held next week in San Francisco. Exelixis’ presentation has been scheduled for Tuesday, January 14, 2020 at 7:30 PM EST / 4:30 PM PST.
Exelixis, Inc. (NASDAQ: EXEL) today announced that based on continued encouraging efficacy and safety data, the company plans to further expand the metastatic castration-resistant prostate cancer (CRPC) cohort of COSMIC-021, the phase 1b trial of cabozantinib (CABOMETYX®) in combination with atezolizumab (TECENTRIQ®) in patients with locally advanced or metastatic solid tumors. The cohort, which was previously expanded from 30 to 80 patients in July 2019, will now include up to 130 patients.
Exelixis, Inc. (NASDAQ:EXEL) today announced a collaboration agreement with Roche to evaluate cabozantinib (CABOMETYX®), Exelixis’ small molecule inhibitor of receptor tyrosine kinases, in combination with atezolizumab (TECENTRIQ®), Roche’s PD-L1 immune checkpoint inhibitor, in patients with locally advanced or metastatic solid tumors. The clinical program, which will be co-funded by the companies, is expected to include three phase 3 pivotal trials in advanced non-small cell lung cancer (NSCLC), castration-resistant prostate cancer (CRPC) and renal cell carcinoma (RCC).
The following is a roundup of top developments in the biotech space over the last 24 hours. Scaling The Peaks (Biotech stocks that hit 52-week highs on Dec. 12.) Allergan plc (NYSE: AGN ) Amgen, Inc. (NASDAQ: ...
Exelixis, Inc. (Nasdaq: EXEL) today announced positive results from IMspire150, the phase 3 trial of atezolizumab (TECENTRIQ®), cobimetinib (COTELLIC®) and vemurafenib (ZELBORAF®) in people with previously untreated BRAF V600 mutation-positive advanced melanoma. Genentech, Inc. (a member of the Roche Group), Exelixis’ collaborator and the sponsor of the IMspire150 trial, informed the company that the study met its primary endpoint of progression-free survival (PFS). Adding atezolizumab to cobimetinib and vemurafenib helped to reduce the risk of disease worsening or death, compared to placebo plus cobimetinib and vemurafenib.
Hedge funds are known to underperform the bull markets but that's not because they are bad at investing. Truth be told, most hedge fund managers and other smaller players within this industry are very smart and skilled investors. Of course, they may also make wrong bets in some instances, but no one knows what the […]
Michael Morrissey became the CEO of Exelixis, Inc. (NASDAQ:EXEL) in 2010. This analysis aims first to contrast CEO...
Since 1986, Farallon Capital has built a proven record for success, mainly from steady hands at the helm and consistent returns for investors. The firm was founded by Tom Steyer, with $15 million in initial capital, and when he retired as managing director in 2012 Farallon had grown to hold over $20 billion in assets under management.Steyer’s successor, Andrew Spokes, has continued the firm’s strategy of ‘absolute return’ investing, assuming every investment has a guaranteed return. As far as stocks are concerned, this investment strategy tends toward the conservative – but it also tends to ensure a good return.So, it makes sense that Farallon would get rid of underperforming or overly risky stocks. In the last quarter, the firm backed out of three high-profile biotech firms.Let’s dive into the TipRanks database to learn more about the doubts and why Farallon is backing out of these biotechs.Sarepta Therapeutics (SRPT)This Massachusetts-based firm takes a focus on genetic disorders, especially muscular dystrophy. Sarepta has one approved product, Exondys 51, a treatment for Duchenne muscular dystrophy, and approved for patients with a confirmed mutation in the DMD gene. With another 16 projects in the pipeline, Sarepta is well positioned for the future. The company is a collaborator on an additional 9 projects.Biotech is a sector with inherent high overhead, high risk, and long lead times to profitability, so Sarepta, like many biotechs focused on clinical phase research, operates at loss. In Q3, the company’s EPS loss increased by 103% year-over-year, to $1.14, even though revenues, at $99 million, showed a 26% yoy gain. The quarterly report noted increased expenditures as the root cause of the increased earnings loss.Interestingly, Farallon divested 500,000 shares – the firm’s entire position in Sarepta. It was a major move by a major fund, that signals a serious lack of confidence in SRPT going forward.At least one Wall Street analyst would agree with Farallon’s position. Hartaj Singh, writing from Oppenheimer, set a Hold on the stock. He wrote, “We believe that with management's focus on early stage gene therapy trials, investor sentiment is slowly shifting to a more skeptical stance on other projects." The analyst added, "While management's (and the Street's) focus has been on the development pipeline, namely SRP-9001, we have highlighted the role a golodirsen CRL could have on the P&L in the medium term. Updates on regulatory actions remain a potential catalyst for 2019, but we keep vigilant on the progress of commercial supply development for SRP-9001. Feasibility of these outlined timelines could be put to the test in 2020." (To watch Singh's track record, click here)Other analysts might have to seriously disagree with Singh. The Street considers Sarepta stock a Strong Buy. According to TipRanks analytics, out of 13 analysts, 12 are bullish, while only one is sidelined. The consensus price target stands at $184.91, showing a 73% upside from the current share price. (See Sarepta stock analysis on TipRanks)Exelixis (EXEL)Located in Alameda, not far from Silicon Valley, Exelixis develops medications for the treatment of a variety of cancers. Unlike many small- to mid-cap biotech companies, Exelixis operates at a profit, thanks to three approved medications on the market. Two of the drugs, Cabometyx and Cometriq, are brand names for cabozantinib, used to treat thyroid and renal cancers, while the third, Cotellic, is used for treatment of melanoma.Having several products on the market for common cancers puts EXEL stock in the black. The company has been running a profit and beating earnings expectations since early in 2018. In its most recent quarterly report, EXEL posted an EPS of 31 cents, beating the 20-cent forecast by an impressive 55%. Still, the EPS was down 24% from the year-ago quarter. The drop in year-over-year earnings came even as revenues, at $271.7 million, increased 20% in the same period.The slide in earnings, despite strong revenues, indicate slower sales than expected – and that induced Farallon to shed 42% of its Exelixis holdings. In all, Farallon sold off 1.25 million shares of EXEL in Q3. Farallon still owns more than $28 million worth of EXEL. It will be interesting to see what the fund does with this stock going forward.5-star BMO analyst George Farmer looks at EXEL and says Hold. He notes the company’s profits, but is cautious on sales. He noted, “Weak Cabometyx sales of $187M, well below ours/consensus of $203M/ $198M, were recorded in spite of a 4.5% price increase last July. We believe this result, ostensibly due to a backlog of patients slow to progress, creates a new overhang on shares…” (To watch Farmer's track record, click here)However, it looks like other analysts aren’t ready to tap out just yet. This stock’s Moderate Buy consensus rating is based on 6 Buys and 3 Holds given in the past three months. Shares are priced at $16.80 and have an average price target of $24.78, indicating upside potential of 48%. (See Exelixis stock analysis on TipRanks)Amarin (AMRN)The company’s omega-3 based drug, Vascepa, is available by prescription as a treatment for hypertriglyceridemia, an indicator for heart disease, and has been shown to have a clear beneficial effect in preventing heart attack. Vascepa was approved and put on the market in 2013, and forecasts show it reaching well over $2 billion in sales by 2024. However, the omega-3 niche is starting to fill up, and Vascepa is facing increasing competition.That competition has not impacted Amarin’s profits – yet. The company’s Q3 results showed $112 million in revenues, a 103% year-over-year gain, and the company has $677 million in cash-on-hand. Vascepa prescription were up 9.9% from Q2, to 865,000 orders.Amarin saw its shares surge as high as 50% this month. The boost came on the heels of FDA AdCom vote in favor of extending the label on the company’s flagship drug, Vascepa, to include patients at risk of a heart attack and other major adverse cardiovascular events. The FDA is set to make a final decision on December 28, 2019.Spokes, however, saw risk here, and Farallon’s sale of Amarin shares was its largest biotech divestment. The firm sold off 2,249,400 shares in AMRN in Q3, reducing its holding by 53% to just over 2 million shares.Two Wall Street analysts become more skeptical about Amarin's valuation earlier this month. Joel Beatty of Citigroup, wrote, “We believe Vascepa is an effective drug and anticipate sales accelerating significantly over the next year, however, we believe this is now already priced into the stock.” Beatty downgraded AMRN from Buy to Hold, although his $27 target suggests an upside of 29% for AMRN. (To watch Beatty's track record, click here)Oppenheimer analyst Leland Gershell is even more downbeat on Amarin. He said, in his recent initiation of coverage report, “We believe that a ~12-month stream of late-stage competitor data starting next month will increasingly weigh on shares as these products, which we believe offer superior profiles, are factored into models.” Gershell’s price target, $7, implies a strong 66% downside here. (To watch Gershell's track record, click here)Overall, Amarin still gets a Moderate Buy from the analyst consensus, with 7 Buys, 2 Holds, and 1 Sell set in recent weeks. The stock has a $27.50 average stock-price forecast, indicating a 35% upside from the $20.42 trading price. (See Amarin stock analysis on TipRanks)
– Approval based on statistically significant and clinically meaningful overall survival benefit demonstrated in the CELESTIAL phase 3 pivotal trial –
-- Results being presented today in a late-breaking presentation (abstract TH-PO1201) at Kidney Week 2019, the annual meeting of the American Society of Nephrology in Washington, D.C. Exelixis, Inc. (EXEL) announced today that its partner Daiichi Sankyo Company, Limited (“Daiichi Sankyo”) has reported positive results from a phase 3 pivotal trial of esaxerenone, a product of the companies’ prior research collaboration, in patients with diabetic nephropathy. Esaxerenone is a novel mineralocorticoid receptor (MR) blocker identified during the prior research collaboration between Exelixis and Daiichi Sankyo and subsequently developed and commercialized by Daiichi Sankyo.