| 0.00% | % of Shares Held by All Insider |
| 20.70% | % of Shares Held by Institutions |
| 20.70% | % of Float Held by Institutions |
| 16 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| BVF Inc. | 8,480,079 | Mar 30, 2019 | 3.59% | 10,092,990 |
| Newtyn Management, LLC | 1,064,501 | Mar 30, 2019 | 0.45% | 1,266,969 |
| Morgan Stanley | 211,795 | Mar 30, 2019 | 0.09% | 252,078 |
| Renaissance Technologies, LLC | 13,800 | Mar 30, 2019 | 0.01% | 16,424 |