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Graybug Vision, Inc. (GRAY)

NasdaqGM - NasdaqGM Real Time Price. Currency in USD
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4.7300+0.4700 (+11.03%)
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Neutralpattern detected
Previous Close4.2600
Bid0.0000 x 1100
Ask0.0000 x 800
Day's Range3.9500 - 4.9600
52 Week Range3.9500 - 37.8800
Avg. Volume409,050
Market Cap99.594M
Beta (5Y Monthly)N/A
PE Ratio (TTM)N/A
Earnings DateN/A
Forward Dividend & YieldN/A (N/A)
Ex-Dividend DateN/A
1y Target EstN/A
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  • Is Graybug Vision Stock a Buy Right Now? This Is What You Need to Know

    Is Graybug Vision Stock a Buy Right Now? This Is What You Need to Know

    Stocks go up, stocks go down, you can't explain that… Or maybe you can, if the stock happens to be a biotech that just flunked a clinical trial. Which leads us nicely to Graybug Vision (GRAY). Or not so nicely if you happen to be an investor. Shares cratered by a dispiriting 51% yesterday after the eye disease drug maker released preliminary data from the Phase 2b ALTISSIMO trial of GB-102 - the company’s twice-yearly intravitreal injection of sunitinib - and candidate for the treatment of wet age-related macular degeneration (wet AMD). Investors were let down by a different set of data, which showed that the Best-corrected visual acuity (BCVA) of the 1mg GB-102 arm, came in 9 letters below the control arm of Eylea, Regeneron’s competing product. On the plus side, after participants took 1mg of GB-102, the treatment displayed promising duration data with approximately 48% of patients staying treatment-free for over 6 months. Additionally, 62% of patients did not need any treatment for at least 4 months or more, with an overall median duration of 5 months. GB-102’s safety profile was favorable, too. Despite being a secondary endpoint in the Phase 2b trial, BCVA is a major primary endpoint for registrational Phase 3 studies in wet AMD, and therefore, a potential key element in the treatment’s overall success. Given that GB-102 showed very stable BCVA in the previous Phase 1/2 studies, Leerink analyst Marc Goodman considers the result a “negative surprise.” “Management doesn’t have a good explanation for this result and will need to investigate this unexpected outcome further, but we are not surprised that the stock is off significantly, as investors are also clearly disappointed by the vision results,” Goodman said. “While we look forward to seeing additional granular data from the ALTISSIMO trial before making any changes to the numbers, we are lowering our POS [probability of success] today from 50% to 25%.” The disappointing data also results in a cut to Goodman’s price target, which is reduced from $45 to $23. Despite the severe haircut, the figure still represents possible upside of a hefty 210%. To this end, Goodman’s rating stays an Outperform (i.e. Buy). (To watch Goodman’s track record, click here) Since the data was published, other Street analysts have been less forgiving, with several downgrading the stock’s rating. Nevertheless, based on 3 Buys and 2 Holds, the stock still boasts a Moderate Buy consensus rating, backed by a bullish $19.60 average price target. Gains of ~165% could be in the cards, should the target be met over the next 12 months. (See GRAY stock analysis on TipRanks) To find good ideas for healthcare stocks trading at attractive valuations, visit TipRanks’ Best Stocks to Buy, a newly launched tool that unites all of TipRanks’ equity insights. Disclaimer: The opinions expressed in this article are solely those of the featured analyst. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

  • Benzinga

    Why Is Graybug Vision Stock Plunging Today?

    Graybug Vision Inc (NASDAQ: GRAY) shares are dropping after preliminary data from Phase 2b ALTISSIMO trial of GB-102 for wet age-related macular degeneration (wet AMD). Investors are reacting to the mean change of best-corrected visual acuity (BCVA) from the baseline that was lower in GB-102 1mg than aflibercept arm. The mean change from baseline for BCVA for all 20 completers was approximately nine letters lower across all time points versus the study control arm. The study was designed to evaluate two separate doses of GB-102, 1mg, and 2mg, injected every six months compared with Regeneron Pharmaceuticals Inc's (NASDAQ: REGN) Eylea (aflibercept) injected every two months. After interim safety analysis, the 2mg dose was discontinued after the initial dose, and all patients were switched to 1mg for their second dose. The median time to first supportive therapy was five months for GB-102 1mg (primary endpoint of the study). Central subfield thickness of the retina in the GB-102 1mg arm was consistent with the study control arm. GB-102, the company's lead product candidate, is a microparticle depot formulation of sunitinib malate, injected intravitreally. Sunitinib is marketed as Sutent by Pfizer Inc (NYSE: PFE). Piper Sandler has downgraded GRAY to Neutral with a price target of $10 from $27 earlier. Price Action: GRAY shares fell 48.2% at $7.65 in market trading hours on the last check Tuesday. Latest Ratings for GRAY DateFirmActionFromTo Mar 2021SVB LeerinkMaintainsOutperform Mar 2021Piper SandlerDowngradesOverweightNeutral Dec 2020Cantor FitzgeraldInitiates Coverage OnOverweight View More Analyst Ratings for GRAY View the Latest Analyst Ratings See more from BenzingaClick here for options trades from BenzingaJ&J Facing Supply Issues, Shaky To Meet EU Q2 Vaccine Deliveries: ReutersFDA Ok's Roche's Companion Diagnostic For Pfizer's Lorbrena In Lung Cancer© 2021 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.