| 8.48% | % of Shares Held by All Insider |
| 0.00% | % of Shares Held by Institutions |
| 0.00% | % of Float Held by Institutions |
| 0 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Group, Inc. (The) | 13,296,940 | Jun 29, 2019 | 9.09% | 228,441,429 |
| Blackrock Inc. | 12,625,128 | Jun 29, 2019 | 8.63% | 216,899,699 |
| Third Security, LLC | 10,712,970 | Jun 29, 2019 | 7.32% | 184,048,824 |
| Bellevue Group AG | 8,247,860 | Jun 29, 2019 | 5.64% | 141,698,234 |
| Invesco Ltd. | 5,387,409 | Jun 29, 2019 | 3.68% | 92,555,686 |
| Iridian Asset Management LLC | 4,851,229 | Jun 29, 2019 | 3.32% | 83,344,114 |
| JP Morgan Chase & Company | 4,823,062 | Jun 29, 2019 | 3.30% | 82,860,205 |
| State Street Corporation | 4,428,475 | Jun 29, 2019 | 3.03% | 76,081,200 |
| Thrivent Financial For Lutherans | 3,785,665 | Jun 29, 2019 | 2.59% | 65,037,724 |
| Pictet Asset Management Ltd | 3,712,062 | Jun 29, 2019 | 2.54% | 63,773,225 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 3,542,787 | Mar 30, 2019 | 2.42% | 57,038,870 |
| Vanguard Small-Cap Index Fund | 3,408,121 | Mar 30, 2019 | 2.33% | 54,870,748 |
| iShares Russell 2000 ETF | 3,130,764 | Jul 30, 2019 | 2.14% | 53,191,680 |
| Fidelity Select Portfolios - Biotechnology | 2,561,377 | Jul 30, 2019 | 1.75% | 43,517,795 |
| First Eagle Fund Of America, Inc. | 2,130,775 | Jan 30, 2019 | 1.46% | 34,475,939 |
| Vanguard Small-Cap Growth Index Fund | 1,916,101 | Mar 30, 2019 | 1.31% | 30,849,226 |
| JP Morgan Small Cap Growth Fund | 1,806,883 | Jun 29, 2019 | 1.23% | 31,042,249 |
| Invesco Small Cap Growth Fund | 1,805,342 | Jun 29, 2019 | 1.23% | 31,015,775 |
| Vanguard Extended Market Index Fund | 1,778,041 | Mar 30, 2019 | 1.22% | 28,626,460 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,542,717 | Jul 30, 2019 | 1.05% | 26,210,761 |