| 1.16% | % of Shares Held by All Insider |
| 75.28% | % of Shares Held by Institutions |
| 76.17% | % of Float Held by Institutions |
| 248 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Redmile Group, LLC | 14,616,560 | Sep 29, 2019 | 9.76% | 35,372,075 |
| Vanguard Group, Inc. (The) | 13,939,556 | Sep 29, 2019 | 9.31% | 33,733,725 |
| Blackrock Inc. | 12,181,989 | Dec 30, 2019 | 8.14% | 62,189,053 |
| Renaissance Technologies, LLC | 10,707,139 | Dec 30, 2019 | 7.15% | 54,659,944 |
| ClearBridge Investments, LLC | 10,364,463 | Sep 29, 2019 | 6.92% | 25,082,000 |
| State Street Corporation | 5,346,426 | Dec 30, 2019 | 3.57% | 27,293,504 |
| Primecap Management Company | 3,693,800 | Sep 29, 2019 | 2.47% | 8,938,996 |
| Morgan Stanley | 2,745,852 | Sep 29, 2019 | 1.83% | 6,644,961 |
| Geode Capital Management, LLC | 2,420,015 | Dec 30, 2019 | 1.62% | 12,354,176 |
| PanAgora Asset Management, Inc. | 2,104,217 | Dec 30, 2019 | 1.41% | 10,742,027 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 3,290,639 | Jun 29, 2019 | 2.20% | 7,140,686 |
| iShares Russell 2000 ETF | 3,157,734 | Oct 30, 2019 | 2.11% | 7,515,406 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 3,016,077 | Oct 30, 2019 | 2.01% | 7,178,263 |
| Primecap Odyssey Growth Fund | 2,400,000 | Sep 29, 2019 | 1.60% | 5,808,000 |
| Vanguard Strategic Equity Fund | 2,379,833 | Sep 29, 2019 | 1.59% | 5,759,195 |
| Vanguard Extended Market Index Fund | 2,090,792 | Jun 29, 2019 | 1.40% | 4,537,018 |
| Vanguard Explorer Fund, Inc. | 1,861,938 | Oct 30, 2019 | 1.24% | 4,431,412 |
| Vanguard Horizon Fund-Strategic Small-Cap Equity Fund | 1,448,576 | Sep 29, 2019 | 0.97% | 3,505,553 |
| iShares NASDAQ Biotechnology ETF | 1,423,182 | Oct 30, 2019 | 0.95% | 3,387,173 |
| Vanguard Horizon Fund-Capital Opportunity Portfolio | 810,800 | Sep 29, 2019 | 0.54% | 1,962,136 |