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Incyte Corporation (INCY)

NasdaqGS - NasdaqGS Delayed Price. Currency in USD
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110.85-4.20 (-3.65%)
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  • w
    wereinayellowsubmarine
    wereinayellowsubmarine
    I'm just reposting this as a summary for those who need a nugget.

    INCY has $1.2 billion in liabilities including $650 million in long term debt. If they use this secondary money to renegotiate their debt terms, then you'll know they're seriously strapped for cash. Not saying they will do this, but just keep an eye for it. If that happens we'll see a 20% correction on top of whatever it already corrected at that time.
  • A
    Anonymous
    Anonymous
    Ok, people expect me to say something about why the price shouls be considered too low now. Long-timers will know that my REAL attitude is that today's price just IS. The famous Graham / Buffett quote about voting machine and weign machine and all. But first, to dispose of the insinuation that something is leaking--the question is, where would it be leaking from? Lilly and Merck simply don't leak. Neither, with a shorter track record, does Incyte. I may have seen occasional pre-reactions to Novartis news, but they aren't a critical spot for Incyte.

    Ok, the meat. What is Inccyte worth? Let's start with the UBS analyst's opinion: "Our price target is based on our NPV sum-of-the-parts analysis, including $49 for Jakafi, $54 for Epacadostat, and $10 for Olumiant." They allow $23 for "everything else." Translating those value components to peak annual income (I've done the math in public before), at a "normal" 7% prime rate that's about $2.2bln for [I'll call it ruxo because presently unapproved uses are included], $2.5bln for epac and $250MM for bari [same reason for using the generic term]. So we can go on to asking how optimistic or pessimistic each number is. Start with $23bln for "everything else." That's pretty cheap for a little drug developer with half a dozen known candidates, ita, the delta drug, the mixed FGFR drug and the GITR drug in phase 2---if the drug developer was for sale, which it isn't. So the $23bln looks reasonable.

    It's hard to be sure about ruxo: it's still only at about half plausible penetration in MF, but above projected penetration in PV. Penetration in ET is probably small at present (the disease isn't generally severe enough to demand off-label treatments), and it's a high prevalence condition. Frankly, I think ruxo will continue expanding into less severe MF, and get a decent penetration into ET on the same basis as it has penetratrd PV (ruxo treats people better than it treats charts; hydroxyurea treats charts MUCH better than it treats peeople). We don't know what penetration ruxo has presently in GvHD, but I doubt much further growth will be available once it comes on-label. So: $2.2bln peak sales looks plausible, maybe conservative.
  • i
    icanpickem
    icanpickem
    15% drop on 2.5% dilution a bit much--look for major recovery next week unless market tanks big time. I thought 120 was a good buying opportunity but nobody is perfect.
  • A
    Anonymous
    Anonymous
    Ok, I spent more time than I should have yesterday groveling through clinicaltrials, looking for a time bomb comparable to the too-large phase 2s of the "treat systemic inflammation to cure cancer" program. Nothing. Some investigator-initiated phase 2s in epac, which is good. An odd-looking phase 2 with the GITR agonist antibody (which is, by the way, a product of the Agenus collaboration), but neither too large nor front-loaded. We're a couple months away from the next time people might expect progress reports on epac + Opdivo. There may be some results on no predictable schedule regarding the epac + Tercentriq combo. Nothing is really expected there, but stopping trials could be taken badly.

    Of course, operating management have NEVER in the history of [post-gene licensing] Incyte owned meaningful amounts of the company's stock, so anyone reading something into operating insider stock sales is [shall I say it?] insane. (and in no position to convince even a somewhat dull portfolio-runner)

    But as I've said before, when a [this] stock leaves its trading range, it's appropriate to look for something that has happened. And frankly, since the re-filing schedule for bari [which includes the end of the rumored disagreement with Lilly about how to proceed) looked like a substantial positive development to me, the shortfall is worse than it looks.

    I think the obvious reason, here, is correct. People, portfolio-runners, are looking at the NewLink presentation on Indoximod and seeing a drug in the same class as epac, with comparable marketing attributes, about as effectve as epac and close enough behind it to market to prevent epac becoming installed as the assumed drug of the class. Now, everything about that interpretation is false, but it makes a heckuva story [DO look on Seeking Alpha for the takedown of the trial presented. Look at a Kaplan-Meier curve for any drug trial in advanced melanoma for a graphic demonstration of why excluding subjects who withdraw (or progress) before a scan at 12 weeks SEVERELY [totally] degrades the value of the result. Consider the expense and staffing requirement of a 700-patient phase 3 and try not to laugh at the idea that NewLink could conduct such a thing on a fast schedule. Oh--and there's no evidence that indoximod acts on the IDO axis] The presentation was made at a small meeting coincident with the major ESMO conference, effectively insulating it from criticism on the spot.

    As we saw with the ruxo patent expiration rumor, even a totally baseless rumor can move a [Incyte's, at least] stock price substantially. And as we've seen with imetelstat, the low quality of data supporting a competitor doesn't necessarily wear off quickly.

    As it happens, we're seeing a classic decay curve in the price of NLNK, supporting the idea that among people payig attention, the weakness of their meeting presentation is becoming known.

    The mechanism by which such a "news" item damages the INCY price is that people only modestly classier than our perma-bashers keep repeating it in places where portfolio runners get information (I'm told that company-restricted Bloomberg chat rooms figure in).

    Is it management's responsibility to fight this? Generally, no. When Feuerstein outright stated the ruxo patent lie in his column, they had an arguable responsibility to correct a false material statement. But for most of this, management's responsibility is to permit the market to be orderly. Trying to manage the stock price [as opposed to its value] is outside the job description and often destructive [Chainsaw Al anyone? Enron?).
  • T
    Tom
    Tom
    there must be some bad news out there, maybe by 4thq report they will be open about it
  • M
    Michael
    Michael
    **remember why your long** Sept 12

    Argus said in a note that it sees bullish growth outlook for Incyte Corporation (NASDAQ: INCY) given its solid late-stage pipeline and key strategic R&D partnerships with companies such as Merck & Co., Inc. (NYSE: MRK), Novartis AG (ADR)(NYSE: NVS), Bristol-Myers Squibb Co (NYSE: BMY) and Eli Lilly and Co (NYSE: LLY).

    The firm has a Buy rating on the shares of the company and a $150 price target.

    Analyst Jasper Hellweg noted that the company's main drug Jakafi is the first and only drug approved for the treatment of myelofibrosis and polycythemia vera, two types of rare blood cancer. The analyst said he likes the growth outlook for Jakafi.

    The analyst also noted that Jakafi's net product revenue was up 33 percent year-over-year in the second quarter to $276 million, helped by patient demand for both of its approved indications. Since the second quarter, the analyst noted that the number of patients on Jakafi rose at a CAGR of 46.5 percent.

    Additionally, Argus is upbeat about the company's other approved drugs and their pipeline, including other oncology drugs and treatments for rheumatoid arthritis and atopic dermatitis.

    The firm said Incyte is perpetually a potential M&A candidate for a larger biotech or big Pharma company. However, the firm noted that the company is not consistently profitable and that its shares are volatile.

    Accordingly, the firm said Incyte is appropriate only for risk-tolerant investors as part of a diversified portfolio.

    Meanwhile, the firm noted that the shares of Incyte have outperformed the S&P 500 over the past quarter, as they have run up by 7.1 percent even as the market has gained only 2.4 percent. However, since the beginning of September, the stock has pulled back by 10 percent.

    The firm recommended using the recent weakness as a buying opportunity.
  • w
    wereinayellowsubmarine
    wereinayellowsubmarine
    If you're one of those pretenders who claim to understand finance, here's a biscuit for you.

    What's the dilution for? A dilution obviously means you need cash. It doesn't mean they planned a dilution and that's the end of it. They can have other secondaries after seeing how the market reacts. A crafty board doesn't schedule a huge secondary all at once, they might follow with a reverse split before issuing another secondary. Or if the damage was limited, then they ight go straight for another secondary. Finance isn't a science. The dilution doesn't mean their cash needs are solved.

    INCY has $1.2 billion in liabilities including $650k in long term debt. This is how you'll know if they're REALLY in need of cash... if they leverage this secondary money to renegotiate their debt. INCY isn't in a financially strong position, and a renegotiated debt with this secondary would signal a serious cash problem.

    I'm not saying this will happen, just that it is one common financial play when a company is cash starved. Watch for this move. If this happens, then we're going to see a 20% correction on top of whatever it already corrected at that time. People aren't scared of a 2.5% dilution, they're scared of what might underlie the need for that cash.
  • M
    Michael
    Michael
    **fun one** JAK inhibitors for hair loss receive US patents

    September 5, 2017
    The US patent office has issued two patents for janus kinase inhibitors for hair loss, according to a press release from Aclaris Therapeutics.

    STORY CONTINUES BELOW

    One of the patents includes coverage for tofacitinib, baricitinib (Olumiant, Incyte & Lilly), ruxolitinib (Jakafi, Incyte) and decernotinib (KareBay Biochem) as therapeutic options for androgenetic alopecia, or pattern hair loss. There are 22 claims in this patent, according to the statement.

    The other patent focuses exclusively on baricitinib as an agent for both inducing hair growth and managing a number of hair loss conditions including alopecia areata and androgenetic alopecia. There are 10 claims included in this patent.
  • w
    wereinayellowsubmarine
    wereinayellowsubmarine
    "The fact is that Incyte has over 1 billion of cash flow now"

    "Michael-P" you are an ignoramus. Seriously?

    They just did a secondary. That speaks volumes "Michael-P". And do you realize that earnings is a paltry $100 million? LOL. You sound so ignorant, it's like I'm dealing with a toddler. When you pretend to understand finance you only embarrass yourself. A supermarket makes high cash flow but low earnings, but that's ok because they sell high volume. Pharm can't do high cash flow/low earnings. Not for long, anyway. Because that means they need to raise money a la secondaries and debt. And voila! There's INCY's secondary explained!

    There is no substitute for earnings. That's why INCY suffers. There's no other reason for INCY's price suffering except that their earnings are more than 200x smaller than their cap and the speculator's drunken spell was broken and they saw what a minefield they walked into. Now they're selling 12 million shares and trying to remember the footsteps they took backwards. The problem is they all want to get out but they're bottlenecked. That's what's going to drive this sub $100 by end of year. Confidence is broken and eventually they will cut losses to avoid disaster. They bought on rumors and they'll sell on rumors. Easy come easy go.
  • M
    Michael-P
    Michael-P
    M&A Monday ... one of these days

    It WILL happen

    My guess is Pfizer... it makes sense.
  • r
    ron
    ron
    Feces
  • M
    Maddison
    Maddison
    gotta say my frustration is building...down 10 days in a row... Company needs to grow up and be more investor friendly.... no news, dilution, etc. etc. Yes, Tommy I am starting to feel the pain.....
  • M
    Michael-P
    Michael-P

    From THE FLY copy/paste:

    Morgan Stanley says baricitinib efficacy could be better if trial design changed
    SEP 15, 2017 | 07:59 EDT
    Morgan Stanley analyst David Risinger said Eli Lilly (LLY) and partner Incyte's (INCY) efficacy data from a Phase 2 study of baricitinib in atopic dermatitis looks inferior to competitors' "on the surface," but he contends that a steroid run-in period and usage during trial makes cross-trial comparison difficult. He thinks better efficacy is likely in Phase 3 if Lilly changes the trial design; however, if it does not, it could "end up being a commercial liability," Risinger tells investors. He keeps an Equal Weight rating and $86 price target on Eli Lilly shares.

    And link here:
    http://thefly.com/thestreet/realmoney/index.php/LLY;INCYid2609899/LLY;INCY-Morgan-Stanley-says-baricitinib-efficacy-could-be-better-if-trial-design-changed

    Home | Trading Strategies, Financial Commentary, Investment Ideas
    Real Money from TheStreet: Financial blogs, trading strategies and conversations with financial advisors, hedge fund managers, CFAs and renowned value investors.
    thefly.com
  • T
    Tom
    Tom
    Date Open High Low Close* Adj Close** Volume
    Jan 12, 2017 114.43 118.25 112.88 117.55 117.55 1,221,500
    Jan 11, 2017 118.80 119.93 113.77 115.29 115.29 2,085,500
    Jan 10, 2017 119.09 121.18 117.80 119.30 119.30 2,013,200
    Jan 09, 2017 113.55 119.89 112.83 118.53 118.53 3,004,200
    Jan 06, 2017 105.42 109.30 104.92 108.31 108.31 1,817,400
    Jan 05, 2017 102.82 104.99 102.24 104.81 104.81 940,900
    Jan 04, 2017 103.10 104.63 102.28 102.84 102.84 1,442,500
    Jan 03, 2017 101.14 103.20 100.41 102.32 102.32 1,434,800
    *Close price adjusted for splits.**Adjusted close price adjusted for both dividends and splits.
  • M
    Michael-P
    Michael-P

    A reminder... Roche bailed on NewLink, and now suddenly NewLink says it has a "winner"? Wouldn't Roche know better? Now NewLink is tumbling, and Incyte appears to maybe have bottomed. I don't understand how NewLink could have presented weak data for Roche, then turn around and have great data once Roche returned the rights to NewLink. Something strange there... Here was the story that broke back in June...

    https://seekingalpha.com/news/3272325-roche-bails-ido-inhibitor-gdcminus-0919-newlink-genetics-15-percent-premarket

    Roche bails on IDO inhibitor GDC-0919; NewLink Genetics down 15% premarket
    Roche's (OTCQX:RHHBY) Genentech has notified NewLink Genetics (NASDAQ:NLNK) that it intends to return the rights to IDO inhibitor GDC-0919 to the company thereby canceling their October 2014 lice
    seekingalpha.com
  • m
    mewe
    mewe
    $INCY keeps on tanking breaking all support levels. I thought buying at 120 was a bargain and I added small bits along the way down. I keep wondering if there are some people with insider info and keep dumbing their positions.
  • w
    wereinayellowsubmarine
    wereinayellowsubmarine
    For people who hate facts to guide their investments, don't read this post. You want to see a CLEAR sell signal? Then look at the volume difference starting Aug 25.

    These are many many consecutive days of high volume selling. When you have sustained selling it means that people are rebalancing or closing positions. Let's make a note of the institutional ownership today it's at 90%. You'll see the market fundamentals in action at the next reporting. My guess is that this move is more than the recent 12 million shares sold. If the price is going to rebound "Michael-P"'s unsubstantiated $300 fantasy, where are the buyers now? They'll have to pick up all these shares first. Sub $100 by EOY.
  • .
    .
    .
    Ok, I'll admit it (as an angry long) Tom, YellowSub, etc. were right about this stock. Yes, bios are down today, but $140 -> 111? Huge Secondary. This company and stock are total garbage. Where's Cramer the BS hyper now? He was hyping this trash at $140+...
  • T
    Tom
    Tom
    i vote maddison
  • M
    Marinshell
    Marinshell
    I think somebody knows something: INCY working on a purchase; cash and stock deal??Might hear something on Merger Monday morning - summer is over, Autumn is beginning, let the mergers begin!