| 12.40% | % of Shares Held by All Insider |
| 78.69% | % of Shares Held by Institutions |
| 89.83% | % of Float Held by Institutions |
| 193 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 8,270,193 | Jun 29, 2019 | 14.99% | 107,347,105 |
| Vanguard Group, Inc. (The) | 4,190,181 | Jun 29, 2019 | 7.59% | 54,388,549 |
| Blackrock Inc. | 3,933,274 | Jun 29, 2019 | 7.13% | 51,053,896 |
| Wasatch Advisors Inc | 2,348,032 | Jun 29, 2019 | 4.26% | 30,477,455 |
| Bellevue Group AG | 2,245,500 | Jun 29, 2019 | 4.07% | 29,146,590 |
| BB Biotech Ag | 2,200,000 | Mar 30, 2019 | 3.99% | 26,796,000 |
| Dimensional Fund Advisors LP | 1,709,500 | Jun 29, 2019 | 3.10% | 22,189,310 |
| Schroder Investment Management Group | 1,430,469 | Jun 29, 2019 | 2.59% | 18,567,487 |
| Samlyn Capital, LLC | 1,032,105 | Jun 29, 2019 | 1.87% | 13,396,722 |
| State Street Corporation | 999,100 | Jun 29, 2019 | 1.81% | 12,968,318 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Growth Company Fund | 3,701,544 | Jun 29, 2019 | 6.71% | 48,046,041 |
| Vanguard Total Stock Market Index Fund | 1,152,383 | Dec 30, 2018 | 2.09% | 13,125,642 |
| Vanguard Small-Cap Index Fund | 1,121,183 | Dec 30, 2018 | 2.03% | 12,770,274 |
| Fidelity Series Growth Company Fund | 1,068,252 | Jun 29, 2019 | 1.94% | 13,865,910 |
| iShares Russell 2000 ETF | 928,647 | Jun 29, 2019 | 1.68% | 12,053,838 |
| Wasatch Small Cap Growth Fund | 747,147 | Dec 30, 2018 | 1.35% | 8,510,004 |
| Vanguard Small Cap Value Index Fund | 715,374 | Dec 30, 2018 | 1.30% | 8,148,109 |
| Vanguard Extended Market Index Fund | 657,180 | Dec 30, 2018 | 1.19% | 7,485,280 |
| iShares NASDAQ Biotechnology ETF | 553,798 | Jun 29, 2019 | 1.00% | 7,188,298 |
| Fidelity Select Portfolios - Biotechnology | 544,748 | Jun 29, 2019 | 0.99% | 7,070,829 |