| 12.40% | % of Shares Held by All Insider |
| 78.69% | % of Shares Held by Institutions |
| 89.83% | % of Float Held by Institutions |
| 193 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 8,267,510 | Mar 30, 2019 | 15.11% | 100,698,271 |
| Vanguard Group, Inc. (The) | 4,216,535 | Mar 30, 2019 | 7.70% | 51,357,396 |
| Blackrock Inc. | 3,849,211 | Mar 30, 2019 | 7.03% | 46,883,389 |
| Wasatch Advisors Inc | 2,361,619 | Mar 30, 2019 | 4.32% | 28,764,519 |
| BB Biotech Ag | 2,200,000 | Mar 30, 2019 | 4.02% | 26,796,000 |
| Dimensional Fund Advisors LP | 1,623,196 | Mar 30, 2019 | 2.97% | 19,770,527 |
| Samlyn Capital, LLC | 1,363,086 | Mar 30, 2019 | 2.49% | 16,602,387 |
| Schroder Investment Management Group | 1,354,712 | Mar 30, 2019 | 2.48% | 16,500,392 |
| State Street Corporation | 990,169 | Mar 30, 2019 | 1.81% | 12,060,258 |
| Rhenman & Partners Asset Management AB | 949,833 | Mar 30, 2019 | 1.74% | 11,568,965 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Growth Company Fund | 3,701,544 | Apr 29, 2019 | 6.76% | 48,749,334 |
| Vanguard Total Stock Market Index Fund | 1,152,383 | Dec 30, 2018 | 2.11% | 13,125,642 |
| Vanguard Small-Cap Index Fund | 1,121,183 | Dec 30, 2018 | 2.05% | 12,770,274 |
| Fidelity Series Growth Company Fund | 1,065,569 | Apr 29, 2019 | 1.95% | 14,033,543 |
| iShares Russell 2000 ETF | 907,492 | Apr 29, 2019 | 1.66% | 11,951,669 |
| Wasatch Small Cap Growth Fund | 747,147 | Dec 30, 2018 | 1.37% | 8,510,004 |
| Vanguard Small Cap Value Index Fund | 715,374 | Dec 30, 2018 | 1.31% | 8,148,109 |
| Vanguard Extended Market Index Fund | 657,180 | Dec 30, 2018 | 1.20% | 7,485,280 |
| iShares NASDAQ Biotechnology ETF | 571,798 | Apr 29, 2019 | 1.04% | 7,530,579 |
| Fidelity Select Portfolios - Biotechnology | 544,748 | Apr 29, 2019 | 1.00% | 7,174,331 |