| 13.32% | % of Shares Held by All Insider |
| 79.73% | % of Shares Held by Institutions |
| 91.98% | % of Float Held by Institutions |
| 119 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| TRV GP II, LLC | 10,230,349 | Mar 30, 2019 | 31.03% | 63,428,163 |
| TRV GP III, LLC | 3,048,780 | Mar 30, 2019 | 9.25% | 18,902,436 |
| Wellington Management Company, LLP | 1,502,158 | Mar 30, 2019 | 4.56% | 9,313,379 |
| Blackrock Inc. | 1,143,104 | Mar 30, 2019 | 3.47% | 7,087,244 |
| FMR, LLC | 1,006,874 | Mar 30, 2019 | 3.05% | 6,242,618 |
| Dimensional Fund Advisors LP | 646,000 | Mar 30, 2019 | 1.96% | 4,005,200 |
| Vanguard Group, Inc. (The) | 611,610 | Mar 30, 2019 | 1.85% | 3,791,982 |
| Omega Fund Management (US) Inc. | 529,965 | Mar 30, 2019 | 1.61% | 3,285,783 |
| AQR Capital Management, LLC | 387,175 | Mar 30, 2019 | 1.17% | 2,400,485 |
| Acadian Asset Management | 291,533 | Mar 30, 2019 | 0.88% | 1,807,504 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Biotechnology | 715,474 | Apr 29, 2019 | 2.17% | 4,063,892 |
| iShares Russell 2000 ETF | 340,992 | Apr 29, 2019 | 1.03% | 1,936,834 |
| Vanguard Extended Market Index Fund | 237,499 | Dec 30, 2018 | 0.72% | 800,371 |
| DFA U.S. Small Cap Series | 221,446 | Jan 30, 2019 | 0.67% | 927,858 |
| Bridgeway Funds Inc-Small Cap Growth Fund | 150,700 | Dec 30, 2018 | 0.46% | 507,859 |
| Bridgeway Funds Inc-Ultra Small Company Market Fund | 147,600 | Dec 30, 2018 | 0.45% | 497,412 |
| Fidelity Growth Company Fund | 143,872 | Apr 29, 2019 | 0.44% | 817,192 |
| iShares Russell 2000 Growth ETF | 140,174 | Apr 29, 2019 | 0.43% | 796,188 |
| Vanguard Variable Insurance Fund-Small Company Growth | 99,674 | Sep 29, 2018 | 0.30% | 647,881 |
| Russell Inv Co-U.S. Small Cap Equity Fund | 83,478 | Oct 30, 2018 | 0.25% | 337,251 |