| 6.08% | % of Shares Held by All Insider |
| 104.64% | % of Shares Held by Institutions |
| 111.42% | % of Float Held by Institutions |
| 132 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Tang Capital Management, LLC | 4,938,893 | Jun 29, 2019 | 18.21% | 45,684,760 |
| FMR, LLC | 4,064,816 | Jun 29, 2019 | 14.98% | 37,599,548 |
| RTW Investments LP | 2,011,340 | Jun 29, 2019 | 7.41% | 18,604,895 |
| Sectoral Asset Management, Inc. | 1,657,171 | Jun 29, 2019 | 6.11% | 15,328,831 |
| Baker Brothers Advisors, LLC | 1,559,231 | Jun 29, 2019 | 5.75% | 14,422,886 |
| Blackrock Inc. | 1,414,765 | Jun 29, 2019 | 5.21% | 13,086,576 |
| Sio Capital Management, LLC | 1,310,367 | Jun 29, 2019 | 4.83% | 12,120,894 |
| VHCP Management III, LLC | 1,251,898 | Jun 29, 2019 | 4.61% | 11,580,056 |
| Millennium Management LLC | 1,052,888 | Jun 29, 2019 | 3.88% | 9,739,214 |
| Vanguard Group, Inc. (The) | 1,045,292 | Jun 29, 2019 | 3.85% | 9,668,951 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Biotechnology | 1,361,589 | Jun 29, 2019 | 5.02% | 12,594,698 |
| Fidelity Advisor Biotechnology Fund | 1,280,788 | Jun 29, 2019 | 4.72% | 11,847,289 |
| Fidelity Small Cap Opportunities Fund | 668,700 | Apr 29, 2019 | 2.46% | 5,383,035 |
| Vanguard Total Stock Market Index Fund | 556,593 | Mar 30, 2019 | 2.05% | 3,578,892 |
| Fidelity Advisor Growth Opportunities Fund | 466,200 | Jun 29, 2019 | 1.72% | 4,312,350 |
| iShares Russell 2000 ETF | 443,314 | Jul 30, 2019 | 1.63% | 3,706,105 |
| Vanguard Extended Market Index Fund | 299,433 | Mar 30, 2019 | 1.10% | 1,925,354 |
| iShares Russell 2000 Growth ETF | 192,476 | Jul 30, 2019 | 0.71% | 1,609,099 |
| Fidelity Stock Selector Small Cap Fund | 131,200 | Apr 29, 2019 | 0.48% | 1,056,160 |
| Variable Insurance Products Fund III-Growth Opportunities | 104,870 | Jun 29, 2019 | 0.39% | 970,047 |