| 17.52% | % of Shares Held by All Insider |
| 78.76% | % of Shares Held by Institutions |
| 95.50% | % of Float Held by Institutions |
| 117 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Flagship Pioneering Inc. | 12,682,876 | Sep 29, 2018 | 31.09% | 96,263,028 |
| FMR, LLC | 6,119,349 | Sep 29, 2018 | 15.00% | 46,445,858 |
| ARK Investment Management, LLC | 4,040,735 | Sep 29, 2018 | 9.90% | 30,669,178 |
| Blackrock Inc. | 2,281,563 | Sep 29, 2018 | 5.59% | 17,317,063 |
| Federated Investors, Inc. | 1,770,255 | Sep 29, 2018 | 4.34% | 13,436,235 |
| Vanguard Group, Inc. (The) | 1,029,643 | Sep 29, 2018 | 2.52% | 7,814,990 |
| Renaissance Technologies, LLC | 756,608 | Sep 29, 2018 | 1.85% | 5,742,654 |
| JP Morgan Chase & Company | 421,494 | Sep 29, 2018 | 1.03% | 3,199,139 |
| State Street Corporation | 391,273 | Sep 29, 2018 | 0.96% | 2,969,762 |
| Shaw D.E. & Co., Inc. | 290,736 | Sep 29, 2018 | 0.71% | 2,206,686 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| ARK ETF Tr-ARK Innovation ETF | 1,346,960 | Apr 29, 2018 | 3.30% | 10,331,183 |
| Federated Kaufmann Fund | 1,300,000 | Jun 29, 2018 | 3.19% | 11,180,000 |
| Fidelity Growth Company Fund | 1,289,798 | Sep 29, 2018 | 3.16% | 9,789,566 |
| Fidelity Select Portfolios - Biotechnology | 1,028,440 | Sep 29, 2018 | 2.52% | 7,805,859 |
| Vanguard Total Stock Market Index Fund | 547,662 | Sep 29, 2018 | 1.34% | 4,156,754 |
| iShares Russell 2000 ETF | 492,216 | Oct 30, 2018 | 1.21% | 3,381,523 |
| iShares NASDAQ Biotechnology ETF | 472,195 | Oct 30, 2018 | 1.16% | 3,243,979 |
| ARK ETF Tr-ARK Genomic Revolution Multi Sector ETF | 468,672 | Apr 29, 2018 | 1.15% | 3,594,714 |
| Fidelity Series Growth Company Fund | 447,332 | Sep 29, 2018 | 1.10% | 3,395,249 |
| Federated Kaufmann Small Cap Fund | 432,800 | Sep 29, 2018 | 1.06% | 3,284,952 |