| 17.50% | % of Shares Held by All Insider |
| 77.62% | % of Shares Held by Institutions |
| 94.07% | % of Float Held by Institutions |
| 109 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Flagship Pioneering Inc. | 12,682,876 | Mar 30, 2019 | 30.86% | 87,131,358 |
| FMR, LLC | 5,822,145 | Mar 30, 2019 | 14.17% | 39,998,136 |
| ARK Investment Management, LLC | 5,287,713 | Mar 30, 2019 | 12.87% | 36,326,588 |
| Blackrock Inc. | 2,200,529 | Mar 30, 2019 | 5.35% | 15,117,634 |
| Renaissance Technologies, LLC | 902,208 | Mar 30, 2019 | 2.20% | 6,198,168 |
| Vanguard Group, Inc. (The) | 901,032 | Mar 30, 2019 | 2.19% | 6,190,089 |
| Nikko Asset Management Americas, Inc. | 818,499 | Mar 30, 2019 | 1.99% | 5,623,088 |
| Sumitomo Mitsui Trust Holdings, Inc. | 801,194 | Mar 30, 2019 | 1.95% | 5,504,202 |
| JP Morgan Chase & Company | 605,849 | Mar 30, 2019 | 1.47% | 4,162,182 |
| State Street Corporation | 401,114 | Mar 30, 2019 | 0.98% | 2,755,653 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| ARK ETF Tr-ARK Innovation ETF | 2,184,356 | Oct 30, 2018 | 5.32% | 15,006,525 |
| Fidelity Growth Company Fund | 2,081,055 | Apr 29, 2019 | 5.06% | 13,610,099 |
| Fidelity Select Portfolios - Biotechnology | 1,633,975 | Apr 29, 2019 | 3.98% | 10,686,196 |
| ARK ETF Tr-ARK Genomic Revolution Multi Sector ETF | 991,661 | Oct 30, 2018 | 2.41% | 6,812,711 |
| Fidelity Series Growth Company Fund | 640,576 | Apr 29, 2019 | 1.56% | 4,189,367 |
| JP Morgan U.S. Small Company Fund | 518,400 | Apr 29, 2019 | 1.26% | 3,390,336 |
| iShares Russell 2000 ETF | 450,218 | Apr 29, 2019 | 1.10% | 2,944,425 |
| iShares NASDAQ Biotechnology ETF | 418,239 | Apr 29, 2019 | 1.02% | 2,735,283 |
| Vanguard Total Stock Market Index Fund | 386,810 | Dec 30, 2018 | 0.94% | 1,748,381 |
| Vanguard Extended Market Index Fund | 295,653 | Dec 30, 2018 | 0.72% | 1,336,351 |