| 17.50% | % of Shares Held by All Insider |
| 77.62% | % of Shares Held by Institutions |
| 94.07% | % of Float Held by Institutions |
| 109 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Flagship Pioneering Inc. | 12,682,876 | Dec 30, 2018 | 30.90% | 57,326,599 |
| FMR, LLC | 6,128,386 | Dec 30, 2018 | 14.93% | 27,700,304 |
| ARK Investment Management, LLC | 4,119,479 | Dec 30, 2018 | 10.04% | 18,620,045 |
| Blackrock Inc. | 2,256,858 | Dec 30, 2018 | 5.50% | 10,200,998 |
| Federated Investors, Inc. | 1,739,228 | Dec 30, 2018 | 4.24% | 7,861,310 |
| Vanguard Group, Inc. (The) | 850,846 | Dec 30, 2018 | 2.07% | 3,845,823 |
| Renaissance Technologies, LLC | 804,908 | Dec 30, 2018 | 1.96% | 3,638,184 |
| JP Morgan Chase & Company | 398,791 | Dec 30, 2018 | 0.97% | 1,802,535 |
| State Street Corporation | 387,209 | Dec 30, 2018 | 0.94% | 1,750,184 |
| Shaw D.E. & Co., Inc. | 307,930 | Dec 30, 2018 | 0.75% | 1,391,843 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Biotechnology | 2,320,475 | Feb 27, 2019 | 5.65% | 14,224,511 |
| ARK ETF Tr-ARK Innovation ETF | 1,964,342 | Jul 30, 2018 | 4.79% | 14,870,068 |
| Fidelity Growth Company Fund | 1,519,355 | Feb 27, 2019 | 3.70% | 9,313,646 |
| Federated Kaufmann Fund | 1,269,880 | Dec 30, 2018 | 3.09% | 5,739,857 |
| ARK ETF Tr-ARK Genomic Revolution Multi Sector ETF | 763,426 | Jul 30, 2018 | 1.86% | 5,779,134 |
| Vanguard Total Stock Market Index Fund | 547,662 | Sep 29, 2018 | 1.33% | 4,156,754 |
| JP Morgan U.S. Small Company Fund | 525,500 | Feb 27, 2019 | 1.28% | 3,221,315 |
| Fidelity Series Growth Company Fund | 514,837 | Feb 27, 2019 | 1.25% | 3,155,950 |
| iShares Russell 2000 ETF | 461,838 | Feb 27, 2019 | 1.13% | 2,831,066 |
| iShares NASDAQ Biotechnology ETF | 438,182 | Feb 27, 2019 | 1.07% | 2,686,055 |