| 17.50% | % of Shares Held by All Insider |
| 77.62% | % of Shares Held by Institutions |
| 94.07% | % of Float Held by Institutions |
| 109 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Flagship Pioneering Inc. | 21,571,764 | Jun 29, 2019 | 30.85% | 69,461,080 |
| FMR, LLC | 8,101,946 | Jun 29, 2019 | 11.59% | 26,088,266 |
| ARK Investment Management, LLC | 7,038,885 | Jun 29, 2019 | 10.07% | 22,665,209 |
| Nikko Asset Management Americas, Inc. | 4,843,074 | Jun 29, 2019 | 6.93% | 15,594,698 |
| Sumitomo Mitsui Trust Holdings, Inc. | 4,843,074 | Jun 29, 2019 | 6.93% | 15,594,698 |
| Perceptive Advisors Llc | 2,500,000 | Jun 29, 2019 | 3.58% | 8,050,000 |
| Blackrock Inc. | 2,323,332 | Jun 29, 2019 | 3.32% | 7,481,129 |
| Vanguard Group, Inc. (The) | 2,060,327 | Jun 29, 2019 | 2.95% | 6,634,252 |
| Renaissance Technologies, LLC | 1,043,408 | Jun 29, 2019 | 1.49% | 3,359,773 |
| Marshall Wace North America L.P. | 972,939 | Jun 29, 2019 | 1.39% | 3,132,863 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Growth Company Fund | 3,281,755 | Jun 29, 2019 | 4.69% | 10,567,251 |
| Fidelity Select Portfolios - Biotechnology | 2,581,206 | Jun 29, 2019 | 3.69% | 8,311,483 |
| ARK ETF Tr-ARK Innovation ETF | 2,348,727 | Jan 30, 2019 | 3.36% | 14,468,158 |
| ARK ETF Tr-ARK Genomic Revolution Multi Sector ETF | 1,078,589 | Jan 30, 2019 | 1.54% | 6,644,108 |
| Fidelity Series Growth Company Fund | 923,276 | Jun 29, 2019 | 1.32% | 2,972,948 |
| JP Morgan U.S. Small Company Fund | 490,600 | Jun 29, 2019 | 0.70% | 1,579,732 |
| iShares Russell 2000 ETF | 444,657 | Jun 29, 2019 | 0.64% | 1,431,795 |
| iShares NASDAQ Biotechnology ETF | 405,054 | Jun 29, 2019 | 0.58% | 1,304,273 |
| Vanguard Total Stock Market Index Fund | 386,810 | Dec 30, 2018 | 0.55% | 1,748,381 |
| Vanguard Extended Market Index Fund | 295,653 | Dec 30, 2018 | 0.42% | 1,336,351 |