| 7.12% | % of Shares Held by All Insider |
| 78.27% | % of Shares Held by Institutions |
| 84.27% | % of Float Held by Institutions |
| 188 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Invesco Ltd. | 4,486,077 | Jun 29, 2019 | 9.18% | 76,128,726 |
| Blackrock Inc. | 4,399,564 | Jun 29, 2019 | 9.00% | 74,660,601 |
| Bellevue Group AG | 4,395,264 | Jun 29, 2019 | 8.99% | 74,587,630 |
| Vanguard Group, Inc. (The) | 3,198,214 | Jun 29, 2019 | 6.54% | 54,273,691 |
| Millennium Management LLC | 2,946,050 | Jun 29, 2019 | 6.03% | 49,994,468 |
| State Street Corporation | 2,623,875 | Jun 29, 2019 | 5.37% | 44,527,158 |
| Ameriprise Financial, Inc. | 2,389,012 | Jun 29, 2019 | 4.89% | 40,541,533 |
| Wasatch Advisors Inc | 1,422,245 | Jun 29, 2019 | 2.91% | 24,135,497 |
| Hood River Capital Management LLC | 1,415,445 | Jun 29, 2019 | 2.89% | 24,020,101 |
| FMR, LLC | 1,282,543 | Jun 29, 2019 | 2.62% | 21,764,754 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Invesco Oppenheimer Global Fund | 2,401,800 | Mar 30, 2019 | 4.91% | 43,184,364 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,629,479 | Jul 30, 2019 | 3.33% | 23,448,202 |
| Vanguard Total Stock Market Index Fund | 1,250,421 | Mar 30, 2019 | 2.56% | 22,482,569 |
| Federated Kaufmann Small Cap Fund | 1,100,200 | Mar 30, 2019 | 2.25% | 19,781,596 |
| iShares Russell 2000 ETF | 1,026,931 | Jul 30, 2019 | 2.10% | 14,777,537 |
| Vanguard Extended Market Index Fund | 597,014 | Mar 30, 2019 | 1.22% | 10,734,311 |
| JNL Series Trust-JNL/Oppenheimer Global Growth Fund | 555,000 | Mar 30, 2019 | 1.14% | 9,978,900 |
| Wasatch Small Cap Growth Fund | 512,111 | Mar 30, 2019 | 1.05% | 9,207,755 |
| Invesco Oppenheimer V.I. Global Fund | 511,180 | Dec 30, 2018 | 1.05% | 6,491,986 |
| Mutual Fund Ser Tr-Eventide Healthcare & Life Sciences Fund | 485,000 | Mar 30, 2019 | 0.99% | 8,720,300 |