| 0.00% | % of Shares Held by All Insider |
| 7.30% | % of Shares Held by Institutions |
| 7.30% | % of Float Held by Institutions |
| 36 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 5,078,619 | Jun 29, 2019 | 63.80% | 122,597,862 |
| Redmile Group, LLC | 733,699 | Jun 29, 2019 | 9.22% | 17,711,493 |
| Franklin Resources, Inc | 669,800 | Jun 29, 2019 | 8.41% | 16,168,972 |
| Deerfield Management Company, L.P. (Series C) | 600,000 | Jun 29, 2019 | 7.54% | 14,484,000 |
| Times Square Capital Management, LLC | 598,000 | Jun 29, 2019 | 7.51% | 14,435,720 |
| Massachusetts Financial Services Co. | 471,524 | Jun 29, 2019 | 5.92% | 11,382,589 |
| Alps Advisors Inc. | 265,420 | Jun 29, 2019 | 3.33% | 6,407,238 |
| Alyeska Investment Group, L.P. | 95,490 | Jun 29, 2019 | 1.20% | 2,305,128 |
| Millennium Management LLC | 86,778 | Jun 29, 2019 | 1.09% | 2,094,820 |
| SEI Investments Co | 58,500 | Jun 29, 2019 | 0.73% | 1,412,190 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Biotechnology | 1,114,727 | Jul 30, 2019 | 14.00% | 33,475,251 |
| Fidelity Diversified International Fund | 739,773 | Jul 30, 2019 | 9.29% | 22,215,383 |
| Fidelity Advisor Biotechnology Fund | 397,244 | Jul 30, 2019 | 4.99% | 11,929,237 |
| Franklin Strategic Series-Franklin Biotechnology Discove | 275,700 | Jan 30, 2019 | 3.46% | 7,179,228 |
| MFS New Discovery Fund | 268,909 | Feb 27, 2019 | 3.38% | 6,919,028 |
| MFS Variable Insurance Trust-MFS New Discovery Series | 154,242 | Mar 30, 2019 | 1.94% | 3,504,378 |
| Fidelity Diversified International K6 Fund | 149,700 | Jul 30, 2019 | 1.88% | 4,495,491 |
| Advanced Series Tr-AST Fidelity Institutional AM Quantitative Port | 116,175 | Mar 30, 2019 | 1.46% | 2,639,496 |
| Fidelity Advisor Diversified International Fund | 104,317 | Jul 30, 2019 | 1.31% | 3,132,639 |
| Fidelity Select Portfolios - Pharmaceuticals | 86,300 | Jul 30, 2019 | 1.08% | 2,591,589 |