| 10.40% | % of Shares Held by All Insider |
| 13.41% | % of Shares Held by Institutions |
| 14.96% | % of Float Held by Institutions |
| 39 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Boxer Capital, LLC | 10,188,312 | Mar 30, 2019 | 7.13% | 11,105,260 |
| Vivo Capital, LLC | 6,818,181 | Mar 30, 2019 | 4.77% | 7,431,817 |
| Vanguard Group, Inc. (The) | 3,578,800 | Mar 30, 2019 | 2.50% | 3,900,892 |
| Broadfin Capital, LLC | 2,727,272 | Mar 30, 2019 | 1.91% | 2,972,726 |
| Stonepine Capital Management, LLC | 2,008,006 | Mar 30, 2019 | 1.40% | 2,188,726 |
| Victory Capital Management Inc. | 1,712,900 | Mar 30, 2019 | 1.20% | 1,867,061 |
| Granite Point Capital Management, L.P. | 1,706,134 | Mar 30, 2019 | 1.19% | 1,859,686 |
| J. Goldman & Co., L.P. | 1,045,000 | Mar 30, 2019 | 0.73% | 1,139,050 |
| Millennium Management LLC | 968,908 | Mar 30, 2019 | 0.68% | 1,056,109 |
| CVI Holdings, LLC | 909,625 | Mar 30, 2019 | 0.64% | 991,491 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 1,428,048 | Dec 30, 2018 | 1.00% | 849,688 |
| Vanguard Extended Market Index Fund | 1,171,741 | Dec 30, 2018 | 0.82% | 697,185 |
| Fidelity Extended Market Index Fund | 434,477 | May 30, 2019 | 0.30% | 417,097 |
| iShares Core S&P Total U.S. Stock Market ETF | 332,056 | May 30, 2019 | 0.23% | 318,773 |
| Fidelity Total Market Index Fund | 160,352 | May 30, 2019 | 0.11% | 153,937 |
| Vanguard Institutional Index-Inst Total Stock Market Ind | 69,805 | Dec 30, 2018 | 0.05% | 41,533 |
| Fidelity Series Total Market Index Fund | 58,281 | May 30, 2019 | 0.04% | 55,949 |
| Vanguard Balanced Index Fund | 38,696 | Dec 30, 2018 | 0.03% | 23,024 |
| USAA Mutual Fd Tr-Extended Market Index Fd | 11,213 | Dec 30, 2018 | 0.01% | 6,671 |