| 5.56% | % of Shares Held by All Insider |
| 93.01% | % of Shares Held by Institutions |
| 98.48% | % of Float Held by Institutions |
| 173 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| SC XII Management LLC | 7,744,460 | Mar 30, 2019 | 11.13% | 159,690,765 |
| Vanguard Group, Inc. (The) | 4,772,109 | Mar 30, 2019 | 6.86% | 98,400,887 |
| Alger (Fred) Management Inc | 4,232,500 | Mar 30, 2019 | 6.08% | 87,274,150 |
| FMR, LLC | 3,616,068 | Mar 30, 2019 | 5.20% | 74,563,322 |
| Jennison Associates LLC | 3,565,307 | Mar 30, 2019 | 5.12% | 73,516,630 |
| Sofinnova Investments, Inc. | 3,100,560 | Mar 30, 2019 | 4.45% | 63,933,547 |
| Millennium Management LLC | 3,018,121 | Mar 30, 2019 | 4.34% | 62,233,655 |
| Blackrock Inc. | 2,776,341 | Mar 30, 2019 | 3.99% | 57,248,151 |
| Capital World Investors | 2,715,580 | Mar 30, 2019 | 3.90% | 55,995,259 |
| Macquarie Group Limited | 2,225,869 | Mar 30, 2019 | 3.20% | 45,897,418 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Smallcap World Fund | 2,715,580 | Mar 30, 2019 | 3.90% | 55,995,259 |
| Alger Small Cap Focus Fund | 1,946,537 | Oct 30, 2018 | 2.80% | 42,745,952 |
| PGIM Jennison Health Sciences Fd | 1,789,756 | May 30, 2019 | 2.57% | 40,985,412 |
| Delaware Group Equity Fds V-Small Cap Core Fund | 1,521,670 | Nov 29, 2018 | 2.19% | 26,355,324 |
| Fidelity Select Portfolios - Medical Technology & Devices Port | 1,280,000 | May 30, 2019 | 1.84% | 29,312,000 |
| Vanguard Total Stock Market Index Fund | 1,145,560 | Dec 30, 2018 | 1.65% | 15,992,017 |
| Vanguard Small-Cap Index Fund | 1,105,670 | Dec 30, 2018 | 1.59% | 15,435,153 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,044,256 | May 30, 2019 | 1.50% | 23,913,462 |
| PGIM Jennison Small Company Fd | 817,529 | May 30, 2019 | 1.17% | 18,721,414 |
| Fidelity Blue Chip Growth Fund | 810,652 | May 30, 2019 | 1.16% | 18,563,930 |