| 0.68% | % of Shares Held by All Insider |
| 103.57% | % of Shares Held by Institutions |
| 104.28% | % of Float Held by Institutions |
| 285 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Group, Inc. (The) | 3,921,465 | Mar 30, 2019 | 9.50% | 149,250,957 |
| Consonance Capital Management LP | 3,652,134 | Mar 30, 2019 | 8.84% | 139,000,220 |
| Blackrock Inc. | 3,316,602 | Mar 30, 2019 | 8.03% | 126,229,872 |
| Macquarie Group Limited | 1,805,866 | Mar 30, 2019 | 4.37% | 68,731,259 |
| Frontier Capital Management Company LLC | 1,379,625 | Mar 30, 2019 | 3.34% | 52,508,527 |
| Rock Springs Capital Management, LP | 1,250,000 | Mar 30, 2019 | 3.03% | 47,575,000 |
| Stephens Investment Management Group | 1,199,737 | Mar 30, 2019 | 2.91% | 45,661,990 |
| ClearBridge Investments, LLC | 1,149,062 | Mar 30, 2019 | 2.78% | 43,733,299 |
| Millennium Management LLC | 1,093,703 | Mar 30, 2019 | 2.65% | 41,626,336 |
| Armistice Capital, LLC | 1,072,000 | Mar 30, 2019 | 2.60% | 40,800,320 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Delaware Group Equity Funds IV-Delaware SMID Cap Growth Fund | 1,943,925 | Dec 30, 2018 | 4.71% | 83,627,653 |
| Vanguard Total Stock Market Index Fund | 1,046,125 | Dec 30, 2018 | 2.53% | 45,004,297 |
| Legg Mason Clearbridge Small Cap Growth Fd | 1,011,719 | Mar 30, 2019 | 2.45% | 38,506,025 |
| Vanguard Small-Cap Index Fund | 1,005,916 | Dec 30, 2018 | 2.44% | 43,274,506 |
| iShares Russell 2000 ETF | 808,332 | May 30, 2019 | 1.96% | 35,170,525 |
| Vanguard Explorer Fund, Inc. | 758,087 | Jan 30, 2019 | 1.84% | 30,838,979 |
| Vanguard Small-Cap Growth Index Fund | 567,304 | Dec 30, 2018 | 1.37% | 24,405,418 |
| Vanguard Extended Market Index Fund | 563,379 | Dec 30, 2018 | 1.36% | 24,236,564 |
| iShares NASDAQ Biotechnology ETF | 421,570 | May 30, 2019 | 1.02% | 18,342,510 |
| College Retirement Equities Fund-Stock Account | 347,196 | Dec 30, 2018 | 0.84% | 14,936,371 |