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Vaxcyte, Inc. (PCVX)

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Previous Close25.20
Open25.23
Bid23.70 x 1000
Ask25.49 x 1000
Day's Range23.07 - 25.53
52 Week Range17.80 - 58.47
Volume456,061
Avg. Volume371,077
Market Cap1.2B
Beta (5Y Monthly)N/A
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EPS (TTM)N/A
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1y Target Est49.75
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    • Vaxcyte Announces Publication of Preclinical Proof-of-Concept Data Supporting Potential of VAX-A1, a Novel Conjugate Vaccine Designed to Prevent Group A Strep Infections
      GlobeNewswire

      Vaxcyte Announces Publication of Preclinical Proof-of-Concept Data Supporting Potential of VAX-A1, a Novel Conjugate Vaccine Designed to Prevent Group A Strep Infections

      FOSTER CITY, Calif., Jan. 06, 2021 (GLOBE NEWSWIRE) -- Vaxcyte, Inc., a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide, today announced the publication of preclinical data for VAX-A1, the Company’s novel Group A Streptococcus (Group A Strep) conjugate vaccine candidate, in the journal Infectious Microbes & Diseases. Group A Strep is one of the leading causes of bacterial infections worldwide, including strep throat and certain severe invasive infections such as sepsis, necrotizing fasciitis and toxic shock syndrome. Strep throat is particularly common in school-age children and a significant source of antibiotic prescriptions globally. The Group A Strep pathogen is also a leading cause of mortality in emerging countries by eliciting immune-mediated diseases such as rheumatic fever and rheumatic heart disease. The World Health Organization (WHO) has recognized the significant public health need caused by Group A Strep and has articulated a strategic goal to develop a safe and globally effective Group A Strep vaccine for prevention of acute infections, secondary immune-mediated sequelae and disease-associated mortality and to reduce reliance on antibiotics to help mitigate the growing concern of antibiotic resistance.In the study, a novel protein and polysaccharide conjugate of the Group A Strep polysaccharide was constructed for inclusion in a universal subunit vaccine against infections by the pathogen. The study demonstrated that active immunization of mice with the vaccine protected against a Group A Strep challenge in systemic infection and localized skin infection models. Moreover, the antibodies induced by the vaccine bound to a wide array of genetically distinct circulating strains of Group A Strep, without evidence of cross-reactivity to human heart or brain tissue antigens.The study referenced in the paper, “Site-Specific Conjugation of Cell Wall Polyrhamnose to Protein SpyAD Envisioning a Safe Universal Group A Streptococcal Vaccine,” was carried out in collaboration with researchers at the Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California School of Medicine and the Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego. The paper can be accessed here.“In these preclinical models, the vaccine showed broad and significant protection against systemic and soft tissue infection after challenge with no evidence of cross-reactivity with human tissue, which supports the path for further development,” said Jeff Fairman, Ph.D., Vice President, Research and Co-founder of Vaxcyte. “Furthermore, by using conserved antigens, we believe that the vaccine could address the full range of pathogenic serotypes of Group A Strep.”Victor Nizet, M.D., a professor of pediatrics and pharmaceutical sciences at UC San Diego who led the preclinical vaccine testing, noted, “Successful immunization against Group A Strep to prevent strep throat, invasive infections and rheumatic heart disease would not only save lives, but also reduce the need for antibiotic prescriptions, which fuel the continual evolution of resistance to these important medications.”Highlights of Findings from the Preclinical Study: * The study examined the efficacy of a novel polysaccharide protein conjugate for a vaccine covering all serotypes of Group A Strep. * The vaccine elicited antibodies that were protective in systemic and soft tissue mouse models of infection. * Broad-based cross-reactivity with multiple M-protein serotypes of Group A Strep was observed in the serum of vaccinated animals. * No cross-reactivity was detected with human heart or brain proteins.About Group A Streptococcus Streptococcus pyogenes (S. pyogenes or Group A Strep) is a preeminent human pathogen causing 700 million cases of disease annually, the majority of which are pharyngitis, commonly known as strep throat. Pharyngitis is highly prevalent in school-age children and a significant source of antibiotic prescriptions, contributing to the growing problem of antibiotic resistance globally. In the United States, an estimated 17.1% of outpatient antibiotic prescriptions dispensed to children aged 3 to 9 years are for treatment of suspected Group A Strep infections. Studies indicate that antibiotic resistance to Group A Strep has significantly increased in this past decade. For example, from 2010 to 2017, the percentage of Group A Strep infections that are resistant to erythromycin has nearly tripled from 8% to 23%, resulting in the elevation of the bacteria by the U.S. Centers for Disease Control (CDC) to the antibiotic resistant category of a “concerning threat.” Group A Strep also increases the risk of severe invasive infections, such as sepsis, necrotizing fasciitis and toxic shock syndrome, and is responsible for post-infectious, immune-mediated rheumatic heart disease (RHD), a leading cause of mortality in emerging countries. Some 30 million people are currently affected by RHD, with over 300,000 deaths in 2015 and 10.5 million disability-adjusted life years lost.About VAX-A1 VAX-A1 is a conjugate vaccine candidate designed to confer broad protective immune responses against all subtypes of Group A Strep and be boostable to offer long-lasting protection from infection. A central component of the vaccine is polyrhamnose, a conserved polysaccharide in the bacterial cell wall, genetically engineered by UC San Diego technology to eliminate an immune epitope implicated in the autoimmune cross-reaction of rheumatic heart disease. Vaxcyte exclusively licensed the rights to this patented antigen and is developing the Group A Strep vaccine utilizing its proprietary conjugation technology. In the research program, the polyrhamnose was conjugated to conserved Group A Strep-specific immunogenic protein carrier using the Company’s site-specific conjugation technology. The resulting conjugate is designed to ensure optimal exposure of both the B-cell and T-cell epitopes on the protein carrier to confer robust, boostable and durable protective immune responses. The vaccine is a combination of this novel conjugate with three additional highly conserved virulence factors, designed to cover all Group A Strep strains.  In July 2019, Vaxcyte received a cost-reimbursement research award from Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator (CARB-X), a global non-profit partnership dedicated to supporting the development of antibiotics, vaccines, diagnostics and other products that address antibiotic-resistant bacteria. The CARB-X award provides funding of up to $2.7 million to support the development of an innovative vaccine to prevent infections caused by Group A Strep bacteria in developing countries and in the developed world. If the project meets certain milestones, Vaxcyte could be eligible to receive additional funding from CARB-X to support further development of the vaccine.About Vaxcyte Vaxcyte is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide. The Company’s cell-free protein synthesis platform, comprising the XpressCFTM platform, exclusively licensed from Sutro Biopharma, Inc., together with Vaxcyte’s proprietary know-how, enables the design and production of protein carriers and antigens, the critical building blocks of vaccines, in ways that the Company believes conventional vaccine technologies currently cannot. Vaxcyte’s lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). Vaxcyte’s pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains, including newly emerging strains responsible for IPD and antibiotic resistance; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease. For more information, visit www.vaxcyte.com.Forward-Looking Statements This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements related to the process and timing of anticipated future development of Vaxcyte’s vaccine candidates, whether preclinical results support further development of its VAX-A1 and the potential success of the VAX-A1 program. The words “believe,” “could,” “expect,” “may,” “potential,” “should,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements are based on Vaxcyte’s current expectations and actual results and timing of events could differ materially from those anticipated in such forward-looking statements as a result of risks and uncertainties, including, without limitation, risks related to Vaxcyte’s product development programs, including development timelines, success and timing of chemistry, manufacturing and controls and related manufacturing activities, potential delays or inability to obtain and maintain required regulatory approvals for its vaccine candidates, and the risks and uncertainties inherent with preclinical and clinical development processes; the success, cost and timing of all development activities and clinical trials; and sufficiency of cash and other funding to support Vaxcyte’s development programs and other operating expenses. These and other risks are described more fully in Vaxcyte’s filings with the Securities and Exchange Commission (SEC), including its Quarterly Report on Form 10-Q filed with the SEC on November 12, 2020 or in other documents Vaxcyte subsequently files with or furnishes to the SEC. Vaxcyte undertakes no duty or obligation to update any forward-looking statements contained in this release as a result of new information, future events or changes in its expectations. Readers should not rely upon the information in this press release as current or accurate after its publication date.The research reported in this news release is supported by the Cooperative Agreement Number IDSEP160030 from ASPR/BARDA and awards from Wellcome Trust, the UK Government’s Global AMR Innovation Fund (GAMRIF) and the German Federal Ministry of Education and Research, as administered by CARB-X. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response, other funders or CARB-X. Investor Contact: Andrew Guggenhime, President & Chief Financial Officer Vaxcyte, Inc. 650-837-0111 investors@vaxcyte.com

    • Vaxcyte Promotes Andrew Guggenhime to President and Chief Financial Officer
      GlobeNewswire

      Vaxcyte Promotes Andrew Guggenhime to President and Chief Financial Officer

      FOSTER CITY, Calif., Dec. 22, 2020 (GLOBE NEWSWIRE) -- Vaxcyte, Inc., formerly known as SutroVax, a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide, today announced the promotion of Andrew Guggenhime from Chief Financial Officer and Chief Business Officer to President and Chief Financial Officer effective January 1, 2021. In this new role, Mr. Guggenhime will lead the finance, human resources, corporate communications, investor relations, business and corporate development, strategy, information technology and facilities activities at Vaxcyte. “Andrew has demonstrated his outstanding leadership capabilities since joining Vaxcyte earlier this year, and brings significant experience across a wide range of functions,” said Grant Pickering, Chief Executive Officer and Co-founder of Vaxcyte. “Today's announcement reflects an evolution in our leadership structure which enables us to continue to scale our organization effectively as we execute on our mission and advance our pipeline of novel vaccine candidates, led by VAX-24, our pneumococcal conjugate vaccine candidate designed to prevent invasive pneumococcal disease.”Mr. Guggenhime joined Vaxcyte in May 2020, bringing more than two decades of finance, strategic and operational leadership experience at both private and public healthcare companies. Mr. Guggenhime joined Vaxcyte from Dermira, Inc., where he served as Chief Financial Officer from April 2014 through the acquisition of the company by Eli Lilly and Company in February 2020. Prior to Dermira, Mr. Guggenhime served as Chief Financial Officer for CardioDx, Inc., a privately held commercial-stage cardiovascular molecular diagnostics company. He also served as Chief Financial Officer for Calistoga Pharmaceuticals, Inc., a privately held, development-stage company, which was acquired by Gilead Sciences, Inc. in 2011, and as Chief Financial Officer for Facet Biotech Corporation, a biotechnology company that was acquired by Abbott Laboratories in April 2010. He previously served as Chief Financial Officer of PDL BioPharma, Inc. until Facet Biotech was spun off from PDL BioPharma in December 2008. Prior to joining Facet Biotech, Mr. Guggenhime served as Chief Financial Officer for Neoforma, Inc. a provider of supply chain management solutions for the healthcare industry, which was acquired by Global Healthcare Exchange, LLC in March 2006. Mr. Guggenhime began his career in financial services at Merrill Lynch & Co. and Wells Fargo & Company. He currently serves on the board of directors of Metacrine, Inc., a biotechnology company. Mr. Guggenhime holds an M.B.A. from the J.L. Kellogg Graduate School of Management at Northwestern University and a B.A. in international politics and economics from Middlebury College.About Vaxcyte Vaxcyte is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide. The Company’s cell-free protein synthesis platform, comprising the XpressCFTM platform, exclusively licensed from Sutro Biopharma, Inc., together with Vaxcyte’s proprietary know-how, enables the design and production of protein carriers and antigens, the critical building blocks of vaccines, in ways that the Company believes conventional vaccine technologies currently cannot. Vaxcyte’s lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). Vaxcyte’s pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains, including newly emerging strains responsible for IPD and antibiotic resistance; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease. For more information, visit www.vaxcyte.com.Contact: Andrew Guggenhime, Chief Financial Officer & Chief Business Officer Vaxcyte, Inc. 650-837-0111 investors@vaxcyte.com

    • Is PCVX A Good Stock To Buy Now?
      Insider Monkey

      Is PCVX A Good Stock To Buy Now?

      Most investors tend to think that hedge funds and other asset managers are worthless, as they cannot beat even simple index fund portfolios. In fact, most people expect hedge funds to compete with and outperform the bull market that we have witnessed in recent years. However, hedge funds are generally partially hedged and aim at […]