| 2.72% | % of Shares Held by All Insider |
| 73.33% | % of Shares Held by Institutions |
| 75.39% | % of Float Held by Institutions |
| 516 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Primecap Management Company | 15,888,770 | Dec 30, 2018 | 7.01% | 547,368,126 |
| Massachusetts Financial Services Co. | 12,615,185 | Dec 30, 2018 | 5.57% | 434,593,123 |
| Deutsche Bank Aktiengesellschaft | 10,790,226 | Dec 30, 2018 | 4.76% | 371,723,285 |
| Wellington Management Company, LLP | 9,957,606 | Dec 30, 2018 | 4.40% | 343,039,526 |
| Vanguard Group, Inc. (The) | 6,831,820 | Dec 30, 2018 | 3.02% | 235,356,199 |
| Blackrock Inc. | 6,607,877 | Dec 30, 2018 | 2.92% | 227,641,362 |
| FIL LTD | 5,503,018 | Dec 30, 2018 | 2.43% | 189,578,970 |
| Hardman Johnston Global Advisors LLC | 4,407,084 | Dec 30, 2018 | 1.95% | 151,824,043 |
| Amundi Pioneer Asset Management | 4,171,442 | Sep 29, 2018 | 1.84% | 158,014,222 |
| Dz Bank Ag Deutsche Zentral Genossenschafts Bank, Frankfurt Am Main | 2,972,176 | Dec 30, 2018 | 1.31% | 102,391,463 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Horizon Fund-Capital Opportunity Portfolio | 7,147,500 | Sep 29, 2018 | 3.15% | 270,747,300 |
| Primecap Odyssey Aggressive Growth Fund | 3,974,388 | Sep 29, 2018 | 1.75% | 150,549,817 |
| Vanguard International Stock Index-Total Intl Stock Indx | 3,260,728 | Oct 30, 2018 | 1.44% | 118,364,426 |
| Templeton Foreign Fund | 3,140,291 | May 30, 2018 | 1.39% | 114,023,966 |
| Primecap Odyssey Growth Fund | 2,948,961 | Sep 29, 2018 | 1.30% | 111,706,642 |
| Templeton Growth Fund, Inc. | 2,046,810 | May 30, 2018 | 0.90% | 74,319,671 |
| MFS International Growth Fund | 1,967,768 | Nov 29, 2018 | 0.87% | 69,737,697 |
| MFS Institutional International Equity Fund | 1,938,504 | Jun 29, 2018 | 0.86% | 70,096,304 |
| First Trust NYSE Arca Biotechnology Index Fund | 1,578,781 | Jun 29, 2018 | 0.70% | 57,088,720 |
| Oppenheimer International Small-Mid Company Fund | 1,549,210 | Aug 30, 2018 | 0.68% | 60,372,713 |