| 2.76% | % of Shares Held by All Insider |
| 72.73% | % of Shares Held by Institutions |
| 74.80% | % of Float Held by Institutions |
| 527 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Primecap Management Company | 15,282,003 | Jun 29, 2019 | 6.78% | 619,685,221 |
| Massachusetts Financial Services Co. | 12,053,604 | Jun 29, 2019 | 5.35% | 488,773,642 |
| Wellington Management Company, LLP | 11,414,007 | Jun 29, 2019 | 5.06% | 462,837,983 |
| Vanguard Group, Inc. (The) | 7,070,710 | Jun 29, 2019 | 3.14% | 286,717,290 |
| Blackrock Inc. | 6,542,645 | Jun 29, 2019 | 2.90% | 265,304,254 |
| Deutsche Bank Aktiengesellschaft | 6,138,773 | Jun 29, 2019 | 2.72% | 248,927,245 |
| FIL LTD | 5,052,109 | Jun 29, 2019 | 2.24% | 204,863,019 |
| Hardman Johnston Global Advisors LLC | 4,219,305 | Jun 29, 2019 | 1.87% | 171,092,817 |
| FMR, LLC | 4,137,724 | Jun 29, 2019 | 1.83% | 167,784,708 |
| First Trust Advisors LP | 2,484,585 | Jun 29, 2019 | 1.10% | 100,749,921 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Horizon Fund-Capital Opportunity Portfolio | 7,147,500 | Mar 30, 2019 | 3.17% | 290,760,300 |
| John Hancock Mutual Fds III-International Growth Fd | 4,190,421 | Jun 29, 2019 | 1.86% | 169,921,571 |
| Primecap Odyssey Aggressive Growth Fund | 3,503,221 | Jun 29, 2019 | 1.55% | 142,055,611 |
| Vanguard International Stock Index-Total Intl Stock Indx | 3,336,784 | Jan 30, 2019 | 1.48% | 123,561,111 |
| Primecap Odyssey Growth Fund | 2,830,443 | Jun 29, 2019 | 1.26% | 114,774,463 |
| First Trust NYSE Arca Biotechnology Index Fund | 2,685,140 | Mar 30, 2019 | 1.19% | 109,231,495 |
| MFS International Growth Fund | 2,234,792 | Feb 27, 2019 | 0.99% | 85,883,056 |
| Vanguard Specialized-Health Care Fund | 2,056,300 | Jan 30, 2019 | 0.91% | 76,144,789 |
| MFS Institutional International Equity Fund | 1,967,122 | Mar 30, 2019 | 0.87% | 80,022,522 |
| Invesco Oppenheimer International Small-Mid Company Fund | 1,549,210 | Feb 27, 2019 | 0.69% | 59,536,140 |