| 2.76% | % of Shares Held by All Insider |
| 72.73% | % of Shares Held by Institutions |
| 74.80% | % of Float Held by Institutions |
| 527 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Primecap Management Company | 15,792,760 | Mar 30, 2019 | 7.00% | 642,449,476 |
| Massachusetts Financial Services Co. | 12,759,906 | Mar 30, 2019 | 5.66% | 519,072,976 |
| Wellington Management Company, LLP | 11,556,255 | Mar 30, 2019 | 5.12% | 470,108,453 |
| Deutsche Bank Aktiengesellschaft | 8,607,147 | Mar 30, 2019 | 3.82% | 350,138,739 |
| Vanguard Group, Inc. (The) | 6,864,416 | Mar 30, 2019 | 3.04% | 279,244,442 |
| Blackrock Inc. | 6,549,939 | Mar 30, 2019 | 2.90% | 266,451,518 |
| Hardman Johnston Global Advisors LLC | 4,312,772 | Mar 30, 2019 | 1.91% | 175,443,564 |
| FIL LTD | 4,139,891 | Mar 30, 2019 | 1.84% | 168,410,765 |
| Dz Bank Ag Deutsche Zentral Genossenschafts Bank, Frankfurt Am Main | 2,707,321 | Mar 30, 2019 | 1.20% | 110,133,818 |
| First Trust Advisors LP | 2,685,140 | Mar 30, 2019 | 1.19% | 109,231,495 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Horizon Fund-Capital Opportunity Portfolio | 7,147,500 | Sep 29, 2018 | 3.17% | 270,747,300 |
| John Hancock Mutual Fds III-International Growth Fd | 4,548,100 | Mar 30, 2019 | 2.02% | 185,016,708 |
| Primecap Odyssey Aggressive Growth Fund | 3,763,488 | Mar 30, 2019 | 1.67% | 153,098,691 |
| Vanguard International Stock Index-Total Intl Stock Indx | 3,260,728 | Oct 30, 2018 | 1.45% | 118,364,426 |
| Primecap Odyssey Growth Fund | 2,948,961 | Mar 30, 2019 | 1.31% | 119,963,733 |
| First Trust NYSE Arca Biotechnology Index Fund | 2,677,633 | Sep 29, 2018 | 1.19% | 101,428,738 |
| MFS International Growth Fund | 1,967,768 | Nov 29, 2018 | 0.87% | 69,737,697 |
| MFS Institutional International Equity Fund | 1,945,809 | Sep 29, 2018 | 0.86% | 73,707,244 |
| Templeton Foreign Fund | 1,912,321 | Aug 30, 2018 | 0.85% | 74,523,149 |
| Oppenheimer International Small-Mid Company Fund | 1,549,210 | Aug 30, 2018 | 0.69% | 60,372,713 |