| 5.92% | % of Shares Held by All Insider |
| 92.97% | % of Shares Held by Institutions |
| 98.82% | % of Float Held by Institutions |
| 251 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Wellington Management Company, LLP | 6,381,870 | Mar 30, 2019 | 11.10% | 442,646,503 |
| Capital Research Global Investors | 6,355,432 | Mar 30, 2019 | 11.06% | 440,812,763 |
| Capital International Investors | 5,568,549 | Mar 30, 2019 | 9.69% | 386,234,558 |
| Vanguard Group, Inc. (The) | 4,893,771 | Mar 30, 2019 | 8.51% | 339,431,956 |
| Blackrock Inc. | 4,745,363 | Mar 30, 2019 | 8.26% | 329,138,377 |
| Price (T.Rowe) Associates Inc | 3,501,623 | Mar 30, 2019 | 6.09% | 242,872,571 |
| FMR, LLC | 2,517,746 | Mar 30, 2019 | 4.38% | 174,630,862 |
| State Street Corporation | 1,921,711 | Mar 30, 2019 | 3.34% | 133,289,874 |
| First Trust Advisors LP | 1,859,052 | Mar 30, 2019 | 3.23% | 128,943,846 |
| Capital World Investors | 1,808,390 | Mar 30, 2019 | 3.15% | 125,429,930 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Growth Fund Of America Inc | 4,535,428 | Mar 30, 2019 | 7.89% | 314,577,286 |
| New Perspective Fund Inc | 3,397,088 | Mar 30, 2019 | 5.91% | 235,622,023 |
| Smallcap World Fund | 1,933,070 | Mar 30, 2019 | 3.36% | 134,077,735 |
| Hartford Mid Cap Fund | 1,731,964 | Oct 30, 2018 | 3.01% | 83,913,655 |
| New Economy Fund (The) | 1,484,906 | Mar 30, 2019 | 2.58% | 102,993,080 |
| First Trust NYSE Arca Biotechnology Index Fund | 1,427,658 | Dec 30, 2018 | 2.48% | 62,074,569 |
| Federated Kaufmann Fund | 1,257,934 | Mar 30, 2019 | 2.19% | 87,250,302 |
| Vanguard Total Stock Market Index Fund | 1,215,699 | Dec 30, 2018 | 2.12% | 52,858,592 |
| Vanguard Small-Cap Index Fund | 1,171,776 | Dec 30, 2018 | 2.04% | 50,948,820 |
| Fidelity Select Portfolios - Biotechnology | 1,062,037 | May 30, 2019 | 1.85% | 58,337,692 |