| 5.12% | % of Shares Held by All Insider |
| 95.64% | % of Shares Held by Institutions |
| 100.80% | % of Float Held by Institutions |
| 127 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| RTW Investments LP | 16,587,491 | Jun 29, 2019 | 32.95% | 248,812,365 |
| Tang Capital Management, LLC | 2,965,485 | Jun 29, 2019 | 5.89% | 44,482,275 |
| Blackrock Inc. | 2,563,600 | Jun 29, 2019 | 5.09% | 38,454,000 |
| Adage Capital Partners GP L.L.C. | 2,157,739 | Jun 29, 2019 | 4.29% | 32,366,085 |
| Cormorant Asset Management, LP | 2,074,595 | Jun 29, 2019 | 4.12% | 31,118,925 |
| Perceptive Advisors Llc | 1,977,412 | Jun 29, 2019 | 3.93% | 29,661,180 |
| Vanguard Group, Inc. (The) | 1,502,349 | Jun 29, 2019 | 2.98% | 22,535,235 |
| Boxer Capital, LLC | 1,466,051 | Jun 29, 2019 | 2.91% | 21,990,765 |
| FMR, LLC | 1,359,787 | Jun 29, 2019 | 2.70% | 20,396,805 |
| Bridger Management LLC | 1,247,366 | Jun 29, 2019 | 2.48% | 18,710,490 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Biotechnology | 1,359,736 | Jul 30, 2019 | 2.70% | 16,561,584 |
| Vanguard Total Stock Market Index Fund | 736,885 | Mar 30, 2019 | 1.46% | 12,924,962 |
| Mutual Fund Ser Tr-Eventide Healthcare & Life Sciences Fund | 708,600 | Mar 30, 2019 | 1.41% | 12,428,844 |
| iShares Russell 2000 ETF | 640,642 | Jul 30, 2019 | 1.27% | 7,803,019 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 509,927 | Jul 30, 2019 | 1.01% | 6,210,910 |
| Price (T.Rowe) New Horizons Fund | 502,480 | Jun 29, 2019 | 1.00% | 7,537,200 |
| iShares NASDAQ Biotechnology ETF | 499,720 | Jul 30, 2019 | 0.99% | 6,086,589 |
| Price (T.Rowe) Health Sciences Fund | 460,662 | Jun 29, 2019 | 0.91% | 6,909,930 |
| Invesco Health Care Fund | 427,394 | Jun 29, 2019 | 0.85% | 6,410,910 |
| Vanguard Extended Market Index Fund | 367,679 | Mar 30, 2019 | 0.73% | 6,449,089 |