| 0.25% | % of Shares Held by All Insider |
| 97.74% | % of Shares Held by Institutions |
| 97.98% | % of Float Held by Institutions |
| 179 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| FMR, LLC | 25,075,725 | Mar 30, 2019 | 15.00% | 64,444,613 |
| Wellington Management Company, LLP | 23,388,484 | Mar 30, 2019 | 13.99% | 60,108,403 |
| Blackrock Inc. | 14,018,349 | Mar 30, 2019 | 8.38% | 36,027,156 |
| State Street Corporation | 7,936,667 | Mar 30, 2019 | 4.75% | 20,397,234 |
| Millennium Management LLC | 6,985,308 | Mar 30, 2019 | 4.18% | 17,952,241 |
| Vanguard Group, Inc. (The) | 6,230,024 | Mar 30, 2019 | 3.73% | 16,011,161 |
| Tamarack Advisers, LP | 5,300,000 | Mar 30, 2019 | 3.17% | 13,621,000 |
| Price (T.Rowe) Associates Inc | 5,095,827 | Mar 30, 2019 | 3.05% | 13,096,275 |
| Oppenheimer Funds, Inc. | 5,000,000 | Mar 30, 2019 | 2.99% | 12,850,000 |
| Rock Springs Capital Management, LP | 4,200,000 | Mar 30, 2019 | 2.51% | 10,794,000 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Growth Company Fund | 11,506,829 | May 30, 2019 | 6.88% | 24,509,545 |
| Invesco Oppenheimer Global Opportunities Fund | 5,000,000 | Dec 30, 2018 | 2.99% | 11,500,000 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 4,680,420 | May 30, 2019 | 2.80% | 9,969,294 |
| Price (T.Rowe) Small-Cap Value Fund | 4,055,100 | Mar 30, 2019 | 2.43% | 10,421,607 |
| iShares Russell 2000 ETF | 3,429,873 | May 30, 2019 | 2.05% | 7,305,629 |
| Fidelity Series Growth Company Fund | 3,327,312 | May 30, 2019 | 1.99% | 7,087,174 |
| Vanguard Extended Market Index Fund | 2,223,331 | Dec 30, 2018 | 1.33% | 5,113,661 |
| iShares NASDAQ Biotechnology ETF | 1,716,046 | May 30, 2019 | 1.03% | 3,655,177 |
| Hartford Healthcare Fund | 1,621,062 | Oct 30, 2018 | 0.97% | 4,652,447 |
| Delaware Group Equity Fds IV-Delaware Healthcare Fund | 1,600,000 | Dec 30, 2018 | 0.96% | 3,680,000 |