| 22.24% | % of Shares Held by All Insider |
| 50.05% | % of Shares Held by Institutions |
| 64.37% | % of Float Held by Institutions |
| 111 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Consonance Capital Management LP | 3,093,690 | Mar 30, 2019 | 8.63% | 22,800,495 |
| Farallon Capital Management LLC | 2,425,000 | Mar 30, 2019 | 6.77% | 17,872,250 |
| Blackrock Inc. | 2,197,491 | Mar 30, 2019 | 6.13% | 16,195,508 |
| Vanguard Group, Inc. (The) | 1,239,460 | Mar 30, 2019 | 3.46% | 9,134,820 |
| Sectoral Asset Management, Inc. | 896,200 | Mar 30, 2019 | 2.50% | 6,604,994 |
| Mangrove Partners | 813,615 | Mar 30, 2019 | 2.27% | 5,996,342 |
| Sofinnova Investments, Inc. | 766,672 | Mar 30, 2019 | 2.14% | 5,650,372 |
| Great Point Partners LLC | 660,366 | Mar 30, 2019 | 1.84% | 4,866,897 |
| State Street Corporation | 442,793 | Mar 30, 2019 | 1.24% | 3,263,384 |
| Brown Advisory Inc. | 406,751 | Mar 30, 2019 | 1.14% | 2,997,754 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| iShares Russell 2000 ETF | 754,350 | Jun 29, 2019 | 2.11% | 1,787,809 |
| Vanguard Total Stock Market Index Fund | 699,205 | Dec 30, 2018 | 1.95% | 5,292,981 |
| Vanguard Extended Market Index Fund | 393,472 | Dec 30, 2018 | 1.10% | 2,978,583 |
| iShares NASDAQ Biotechnology ETF | 377,079 | Jun 29, 2019 | 1.05% | 893,677 |
| Fidelity Small Cap Growth Fund | 314,540 | Apr 29, 2019 | 0.88% | 3,359,287 |
| iShares Russell 2000 Growth ETF | 280,375 | Jun 29, 2019 | 0.78% | 664,488 |
| Financial Investors Tr-Emerald Growth Fund | 186,939 | Jan 30, 2019 | 0.52% | 1,418,867 |
| Fidelity Extended Market Index Fund | 124,425 | May 30, 2019 | 0.35% | 1,348,767 |
| Fidelity Small Cap Index Fund | 113,722 | Apr 29, 2019 | 0.32% | 1,214,550 |
| iShares Micro Cap ETF | 83,428 | Jun 29, 2019 | 0.23% | 197,724 |