| 5.69% | % of Shares Held by All Insider |
| 86.30% | % of Shares Held by Institutions |
| 91.50% | % of Float Held by Institutions |
| 146 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Woodford Investment Management LTD | 13,379,979 | Mar 30, 2019 | 23.83% | 303,324,123 |
| Baupost Group, Inc,.(The) LLC | 9,309,168 | Mar 30, 2019 | 16.58% | 211,038,838 |
| FMR, LLC | 8,195,049 | Mar 30, 2019 | 14.60% | 185,781,760 |
| Vanguard Group, Inc. (The) | 3,878,225 | Mar 30, 2019 | 6.91% | 87,919,360 |
| Blackrock Inc. | 3,716,673 | Mar 30, 2019 | 6.62% | 84,256,976 |
| Price (T.Rowe) Associates Inc | 1,210,979 | Mar 30, 2019 | 2.16% | 27,452,893 |
| State Street Corporation | 903,754 | Mar 30, 2019 | 1.61% | 20,488,103 |
| Norges Bank Investment Management | 876,173 | Dec 30, 2018 | 1.56% | 22,421,267 |
| Morgan Stanley | 687,392 | Mar 30, 2019 | 1.22% | 15,583,176 |
| Northern Trust Corporation | 550,082 | Mar 30, 2019 | 0.98% | 12,470,358 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Growth Company Fund | 1,526,108 | Mar 30, 2019 | 2.72% | 34,596,868 |
| Fidelity Select Portfolios - Health Care | 1,292,500 | Mar 30, 2019 | 2.30% | 29,300,975 |
| Vanguard Small-Cap Index Fund | 1,054,823 | Sep 29, 2018 | 1.88% | 34,461,067 |
| Vanguard Total Stock Market Index Fund | 1,040,016 | Sep 29, 2018 | 1.85% | 33,977,322 |
| iShares Russell 2000 ETF | 924,517 | Mar 30, 2019 | 1.65% | 20,958,800 |
| Fidelity Advisor Biotechnology Fund | 709,334 | Mar 30, 2019 | 1.26% | 16,080,601 |
| Fidelity Small Cap Opportunities Fund | 663,172 | Jan 30, 2019 | 1.18% | 17,275,630 |
| Vanguard Small-Cap Growth Index Fund | 609,962 | Sep 29, 2018 | 1.09% | 19,927,458 |
| iShares NASDAQ Biotechnology ETF | 579,812 | Mar 30, 2019 | 1.03% | 13,144,338 |
| Vanguard Extended Market Index Fund | 564,103 | Sep 29, 2018 | 1.00% | 18,429,245 |