| 11.84% | % of Shares Held by All Insider |
| 64.96% | % of Shares Held by Institutions |
| 73.68% | % of Float Held by Institutions |
| 159 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| RA Capital Management, LLC | 8,198,337 | Dec 30, 2018 | 9.90% | 33,613,181 |
| venBio Select Advisor LLC | 4,750,000 | Dec 30, 2018 | 5.74% | 19,475,000 |
| Blackrock Inc. | 4,519,331 | Dec 30, 2018 | 5.46% | 18,529,257 |
| State Street Corporation | 4,342,618 | Dec 30, 2018 | 5.24% | 17,804,733 |
| Bridger Management LLC | 3,791,531 | Dec 30, 2018 | 4.58% | 15,545,277 |
| FMR, LLC | 2,723,437 | Dec 30, 2018 | 3.29% | 11,166,091 |
| Vanguard Group, Inc. (The) | 1,979,668 | Dec 30, 2018 | 2.39% | 8,116,638 |
| Great Point Partners LLC | 1,950,000 | Sep 29, 2018 | 2.35% | 10,920,000 |
| Credit Agricole S.A. | 1,307,428 | Dec 30, 2018 | 1.58% | 5,360,454 |
| Renaissance Technologies, LLC | 875,900 | Dec 30, 2018 | 1.06% | 3,591,190 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 2,837,967 | Nov 29, 2018 | 3.43% | 14,303,353 |
| Fidelity Select Portfolios - Biotechnology | 2,723,437 | Nov 29, 2018 | 3.29% | 13,726,122 |
| Vanguard Total Stock Market Index Fund | 1,670,142 | Sep 29, 2018 | 2.02% | 9,352,795 |
| iShares Russell 2000 ETF | 1,408,830 | Nov 29, 2018 | 1.70% | 7,100,503 |
| Franklin Strategic Series-Small Cap Growth Fund | 875,000 | Apr 29, 2018 | 1.06% | 12,556,250 |
| Vanguard Extended Market Index Fund | 867,560 | Sep 29, 2018 | 1.05% | 4,858,336 |
| iShares Russell 2000 Growth ETF | 567,422 | Nov 29, 2018 | 0.69% | 2,859,806 |
| Franklin Strategic Series-Franklin Biotechnology Discove | 504,000 | Apr 29, 2018 | 0.61% | 7,232,400 |
| Fidelity Extended Market Index Fund | 289,019 | Nov 29, 2018 | 0.35% | 1,456,655 |
| JP Morgan U.S. Small Company Fund | 248,900 | Nov 29, 2018 | 0.30% | 1,254,456 |