| 11.16% | % of Shares Held by All Insider |
| 68.87% | % of Shares Held by Institutions |
| 77.52% | % of Float Held by Institutions |
| 155 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| RA Capital Management, LLC | 8,198,337 | Mar 30, 2019 | 9.32% | 65,914,629 |
| Millennium Management LLC | 4,905,786 | Mar 30, 2019 | 5.58% | 39,442,519 |
| Blackrock Inc. | 4,437,891 | Mar 30, 2019 | 5.04% | 35,680,643 |
| Bridger Management LLC | 4,003,481 | Mar 30, 2019 | 4.55% | 32,187,987 |
| Vanguard Group, Inc. (The) | 3,375,742 | Mar 30, 2019 | 3.84% | 27,140,965 |
| State Street Corporation | 3,276,966 | Mar 30, 2019 | 3.73% | 26,346,806 |
| FMR, LLC | 2,402,037 | Mar 30, 2019 | 2.73% | 19,312,377 |
| Opaleye Management Inc. | 1,366,062 | Mar 30, 2019 | 1.55% | 10,983,138 |
| Credit Agricole S.A. | 1,307,428 | Mar 30, 2019 | 1.49% | 10,511,721 |
| Point72 Asset Management, L.P. | 1,278,900 | Mar 30, 2019 | 1.45% | 10,282,356 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Fidelity Select Portfolios - Biotechnology | 2,027,037 | May 30, 2019 | 2.30% | 12,709,521 |
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 2,021,325 | May 30, 2019 | 2.30% | 12,673,707 |
| iShares Russell 2000 ETF | 1,309,924 | May 30, 2019 | 1.49% | 8,213,223 |
| Vanguard Extended Market Index Fund | 919,526 | Dec 30, 2018 | 1.05% | 3,770,056 |
| iShares Russell 2000 Growth ETF | 532,910 | May 30, 2019 | 0.61% | 3,341,345 |
| Vanguard Total Stock Market Index Fund | 351,572 | Dec 30, 2018 | 0.40% | 1,441,445 |
| Fidelity Extended Market Index Fund | 346,215 | May 30, 2019 | 0.39% | 2,170,768 |
| Franklin Strategic Series-Franklin Biotechnology Discove | 339,700 | Oct 30, 2018 | 0.39% | 1,545,635 |
| Fidelity Small Cap Index Fund | 256,252 | Apr 29, 2019 | 0.29% | 2,037,203 |
| Franklin Strategic Series-Small Cap Growth Fund | 247,875 | Oct 30, 2018 | 0.28% | 1,127,831 |