| 2.88% | % of Shares Held by All Insider |
| 68.49% | % of Shares Held by Institutions |
| 70.52% | % of Float Held by Institutions |
| 48 | Number of Institutions Holding Shares |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Nantahala Capital Management, LLC | 6,581,465 | Mar 30, 2019 | 14.16% | 6,185,260 |
| RTW Investments LP | 4,480,565 | Mar 30, 2019 | 9.64% | 4,210,834 |
| Stonepine Capital Management, LLC | 3,403,402 | Mar 30, 2019 | 7.32% | 3,198,517 |
| Hood River Capital Management LLC | 2,972,616 | Mar 30, 2019 | 6.39% | 2,793,664 |
| UBS Group AG | 2,362,745 | Mar 30, 2019 | 5.08% | 2,220,507 |
| HighTower Advisors, LLC | 1,910,951 | Mar 30, 2019 | 4.11% | 1,795,911 |
| Vanguard Group, Inc. (The) | 1,830,177 | Mar 30, 2019 | 3.94% | 1,720,000 |
| Meitav Dash Investments Ltd | 988,573 | Mar 30, 2019 | 2.13% | 929,060 |
| Blackrock Inc. | 743,051 | Mar 30, 2019 | 1.60% | 698,319 |
| Polar Capital LLP | 602,684 | Mar 30, 2019 | 1.30% | 566,402 |
| Holder | Shares | Date Reported | % Out | Value |
|---|---|---|---|---|
| Vanguard Total Stock Market Index Fund | 1,048,461 | Dec 30, 2018 | 2.26% | 1,100,884 |
| Roxbury/Hood River Small Cap Growth Fund | 824,627 | Mar 30, 2019 | 1.77% | 774,984 |
| Vanguard Extended Market Index Fund | 570,640 | Dec 30, 2018 | 1.23% | 599,172 |
| Fidelity Extended Market Index Fund | 129,860 | May 30, 2019 | 0.28% | 72,085 |
| iShares Micro Cap ETF | 81,915 | May 30, 2019 | 0.18% | 45,471 |
| Fidelity NASDAQ Composite Index Fund | 62,000 | May 30, 2019 | 0.13% | 34,416 |
| Fidelity Total Market Index Fund | 33,354 | May 30, 2019 | 0.07% | 18,514 |
| Vanguard Institutional Index-Inst Total Stock Market Ind | 28,575 | Dec 30, 2018 | 0.06% | 30,003 |
| Vanguard Balanced Index Fund | 22,283 | Dec 30, 2018 | 0.05% | 23,397 |
| Fidelity Series Total Market Index Fund | 12,123 | May 30, 2019 | 0.03% | 6,729 |