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AC Immune SA (ACIU)

NasdaqGM - NasdaqGM Real Time Price. Currency in USD
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6.51-0.22 (-3.27%)
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Neutralpattern detected
Previous Close6.73
Open6.72
Bid0.00 x 800
Ask0.00 x 2200
Day's Range6.40 - 6.74
52 Week Range4.42 - 13.00
Volume259,344
Avg. Volume1,010,818
Market Cap473.288M
Beta (5Y Monthly)0.80
PE Ratio (TTM)N/A
EPS (TTM)-0.94
Earnings DateMay 03, 2021 - May 07, 2021
Forward Dividend & YieldN/A (N/A)
Ex-Dividend DateN/A
1y Target Est13.86
  • AC Immune Hosts Investor Webinar Highlighting the Power of its Morphomer™ Platform to Enable Precision Medicine for Neurodegenerative Disease
    GlobeNewswire

    AC Immune Hosts Investor Webinar Highlighting the Power of its Morphomer™ Platform to Enable Precision Medicine for Neurodegenerative Disease

    Clinically validated platform accelerates the discovery and development of first-in-class small molecule therapeutics in parallel with companion diagnosticsLAUSANNE, Switzerland, March 31, 2021 (GLOBE NEWSWIRE) -- AC Immune SA (NASDAQ: ACIU), a clinical-stage biopharmaceutical company pioneering precision medicine for neurodegenerative diseases, will host an investor webinar today to discuss the unique benefits of the Company’s innovative MorphomerTM technology platform, which generates first-in-class therapeutic and diagnostic candidates to power AC Immune’s precision medicine approach for neurodegenerative diseases. The live webinar begins at 10am ET and can be accessed here. Prof. Andrea Pfeifer, Ph.D., CEO of AC Immune SA, commented: “Our industry-leading precision medicine approach aims to address the complexity and heterogeneity of neurodegenerative diseases by pairing highly selective and conformation-specific therapeutics with first- or best-in-class companion diagnostics. This approach is fueled, in part, by our clinically validated MorphomerTM platform, which combines decades of medicinal chemistry and drug development expertise to accelerate the design, synthesis, and development of brain- and cell-penetrant small molecules capable of binding to intracellular pathological proteins. “Through the successful application of this platform, we are advancing a comprehensive pipeline of therapeutic and diagnostic Morphomers™ that address key targets such as Tau, TDP-43, alpha-synuclein, and the NLRP3 inflammasome. We are pleased to provide an overview of the discovery and development of these programs, several of which have been validated in the clinic, as well as outline the significant milestones we expect to achieve across our portfolio or Morphomer™- and SupraAntigen™-derived portfolio over the coming months.” The webinar features presentations and a Q&A session with members of AC Immune’s Management and Research and Development Teams: Prof. Andrea Pfeifer; Dr. Marie Kosco-Vilbois, Chief Scientific Officer; Dr. Sonia Poli, Life Cycle Leader; and Dr. Francesca Capotosti, Group Leader, in vivo Pharmacology and Non-Clinical Safety. Key highlights from the event: AC Immune’s Morphomer™ technology enables the Company to deliver on its vision for precision medicine by fulfilling the need for differentiated therapies and a more comprehensive panel of diagnostic agents to characterize neurodegenerative diseases at the individual patient level. Brain- and cell-penetrant Morphomer™ therapeutics that disrupt and/or inhibit intracellular protein aggregation may preserve neurons and prevent spreading of pathology and disease progressionEarlier, more reliable detection of specific neuropathologies may unlock the value of disease-modifying therapeutics and create a pathway for personalized combination therapies AC Immune’s Morphomer™ platform has generated significant value through partnership and clinical validation and will continue to drive future value as early-stage programs mature. Tau-targeted therapeutic and diagnostic Morphomers™ have generated more than CHF 174 million to date from strategic partnerships with the potential for considerable future milestone payments and royaltiesThe Company’s current portfolio of therapeutic and diagnostic Morphomer™ candidates targeting TDP-43, alpha-synuclein and the NLRP3 inflammasome can address multiple significant market opportunities in neurodegenerative and non-CNS indicationsThe Morphomer™ platform can rapidly deliver first-/best-in-class small molecule candidates against emerging targets The unique benefits and competitive advantages of AC Immune’s MorphomerTM platform include: A highly focused, proprietary library of ~12,000 conformation-specific small molecules reflecting years of know-how and enrichment for compounds that bind mis-folded, aggregated protein structuresEfficient generation of CNS-optimized compounds with favorable brain penetration and pharmacokineticsRational design and deep expertise in medicinal chemistry to ensure optimized candidates bind selectively to pathological forms of misfolded proteins inside neurons at the earliest stage of diseaseA proprietary suite of cellular and functional assays that use patient-derived brain samples to enable rapid identification and validation of successful compoundsBroad applicability as potentially disease-modifying therapies as well as precision diagnostics, directed against both established and novel neurodegenerative disease targetsValidation both clinically and through collaboration agreements with industry leaders Eli Lilly and Company and Life Molecular Imaging Morphomer Tau candidate ACI-3024 achieves potentially therapeutic target levels in the cerebrospinal fluid (CSF) at the highest administered dose in a Phase 1 study – the first therapeutic Morphomer candidate to be tested in humans. Single and multiple dosing with ACI-3024 resulted in dose-dependent exposure, and after multiple doses, ACI-3024 concentrations in CSF exceeded target concentrations based on animal studiesACI-3024 is being evaluated for efficacy in models of rare Tauopathies, while AC Immune and strategic partner Eli Lilly and Company have decided to pursue other promising Tau Morphomer candidates with the desired CSF exposure and selectivity for pathological aggregated Tau for potential clinical development in Alzheimer’s diseasePlatform validation has positive readthrough for earlier-stage candidates targeting a-syn and NLRP3 Morphomer™-derived positron emission tomography (PET) imaging agents are first-/best-in-class, representing potential game changers for alpha-synuclein-, TDP-43- and certain Tau-driven diseases. Published results for AC Immune’s differentiated Tau PET tracer, PI-2620, demonstrate its ability to reliably detect 3- and 4-repeat Tau protein, identifying early Tau pathology in Alzheimer’s disease patients and reproducibly differentiating patients with Alzheimer’s and progressive supranuclear palsy from those with other disease pathologies such as alpha-synucleinopathiesClinical-stage alpha-synuclein PET tracer ACI-12589 provides specific signal in tissue from Parkinson’s disease patients and differentiates between disease and non-disease controlsFirst-in-class TDP-43 PET tracer candidates show nanomolar affinities on patient-derived brain tissue and rapid uptake in vivo Dr. Kosco-Vilbois concluded: “As the field expands its understanding of co-pathologies and the heterogeneity inherent to neurodegenerative diseases, it becomes increasingly clear that precision medicine will be the future of this treatment landscape. Our proprietary Morphomer™ and SupraAntigen™ technology platforms and the deep expertise at AC Immune give us the ability to remain at the forefront of this paradigm shift.” About AC Immune SA AC Immune SA is clinical-stage biopharmaceutical company that aims to become a global leader in precision medicine for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and NeuroOrphan indications driven by misfolded proteins. The Company’s two clinically validated technology platforms, SupraAntigenTM and MorphomerTM, fuel its broad and diversified pipeline of first- and best-in-class assets, which currently features nine therapeutic and three diagnostic candidates, six of which are currently in clinical trials. AC Immune has a strong track record of securing strategic partnerships with leading global pharmaceutical companies including Genentech, a member of the Roche Group, Eli Lilly and Company, and Janssen Pharmaceuticals, Inc., resulting in substantial non-dilutive funding to advance its proprietary programs and >$3 billion in potential milestone payments. For further information, please contact: Head of Investor RelationsJoshua Drumm, Ph.D.AC ImmunePhone: +1 917 809 0814Email: joshua.drumm@acimmune.comUS MediaKatie GallagherLaVoie Health SciencePhone: +1 617 792 3937Email: kgallagher@lavoiehealthscience.com European Investors & MediaChris MaggosLifeSci AdvisorsPhone: +41 79 367 6254 Email: chris@lifesciadvisors.com Forward looking statementsThis press release contains statements that constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical fact and may include statements that address future operating, financial or business performance or AC Immune’s strategies or expectations. In some cases, you can identify these statements by forward-looking words such as “may,” “might,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “projects,” “potential,” “outlook” or “continue,” and other comparable terminology. Forward-looking statements are based on management’s current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include those described under the captions “Item 3. Key Information – Risk Factors” and “Item 5. Operating and Financial Review and Prospects” in AC Immune’s Annual Report on Form 20-F and other filings with the Securities and Exchange Commission. These include: the impact of Covid-19 on our business, suppliers, patients and employees and any other impact of Covid-19. Forward-looking statements speak only as of the date they are made, and AC Immune does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law. All forward-looking statements are qualified in their entirety by this cautionary statement.

  • These Analysts Just Made A Sizeable Downgrade To Their AC Immune SA (NASDAQ:ACIU) EPS Forecasts
    Simply Wall St.

    These Analysts Just Made A Sizeable Downgrade To Their AC Immune SA (NASDAQ:ACIU) EPS Forecasts

    One thing we could say about the analysts on AC Immune SA ( NASDAQ:ACIU ) - they aren't optimistic, having just made a...

  • AC Immune to Host Webinar Highlighting its Innovative Morphomer™ Technology Platform and Pipeline
    GlobeNewswire

    AC Immune to Host Webinar Highlighting its Innovative Morphomer™ Technology Platform and Pipeline

    Therapeutic and diagnostic Morphomers™ enable AC Immune’s unique precision medicine approach for neurodegenerative diseases Webinar will take place on Wednesday, March 31, 2020 at 10:00 AM ET LAUSANNE, Switzerland, March 26, 2021 (GLOBE NEWSWIRE) -- AC Immune SA (NASDAQ: ACIU), a clinical-stage biopharmaceutical company pioneering precision medicine for neurodegenerative diseases, today announced that it will host a corporate update webinar on Wednesday, March 31st at 10:00 AM ET until 11:30 AM ET. During the webinar, members of the AC Immune Management and Research and Development Teams will discuss the unique benefits of the Company’s innovative Morphomer™ technology platform, which accelerates the design, synthesis, and development of CNS-optimized, conformation-specific small molecules directed against pathological proteins. The platform has produced multiple clinically validated therapeutic and diagnostic candidates that bind selectively to target proteins intracellularly, at the earliest stages of disease. The current Morphomer™ pipeline includes two clinical-stage diagnostic candidates (Tau-PET tracer and alpha-synuclein-PET tracer), and one therapeutic candidate that has completed Phase 1 (Morphomer™ Tau ACI-3024). Additional first-in-class Morphomer™-derived therapeutic and diagnostic candidates targeting Tau, alpha-synuclein, TDP-43 and NLRP3-ASC are in preclinical development. Together with the Company’s SupraAntigen™-derived therapeutic antibody and vaccine candidates, AC Immune’s comprehensive Morphomer™ pipeline enables a differentiated Precision Medicine approach against multiple key proteins by pairing the Company’s targeted therapeutics with proprietary companion diagnostics. Following the formal presentations, there will be an interactive virtual roundtable discussion between the audience and the AC Immune Management and Research and Development Teams. To register for the webinar, please click here. Webinar Speakers Andrea Pfeifer, Ph.D. Chief Executive OfficerAC Immune Marie Kosco-Vilbois, Ph.D. Chief Scientific OfficerAC Immune Sonia Poli, Ph.D.Life Cycle LeaderAC Immune Francesca Capotosti, Ph.D.Group Leader, In vivo Pharmacology and Non-Clinical SafetyAC Immune About AC Immune SA AC Immune SA is clinical-stage biopharmaceutical company that aims to become a global leader in precision medicine for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and NeuroOrphan indications driven by misfolded proteins. The Company’s two clinically validated technology platforms, SupraAntigenTM and MorphomerTM, fuel its broad and diversified pipeline of first- and best-in-class assets, which currently features nine therapeutic and three diagnostic candidates, six of which are currently in clinical trials. AC Immune has a strong track record of securing strategic partnerships with leading global pharmaceutical companies including Genentech, a member of the Roche Group, Eli Lilly and Company, and Janssen Pharmaceuticals, Inc., resulting in substantial non-dilutive funding to advance its proprietary programs and >$3 billion in potential milestone payments. For further information, please contact: Head of Investor RelationsJoshua Drumm, Ph.D.AC ImmunePhone: +1 917 809 0814Email: joshua.drumm@acimmune.comUS MediaKatie GallagherLaVoie Health SciencePhone: +1 617 792 3937Email: kgallagher@lavoiehealthscience.com European Investors & MediaChris MaggosLifeSci AdvisorsPhone: +41 79 367 6254 Email: chris@lifesciadvisors.com Forward looking statementsThis press release contains statements that constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical fact and may include statements that address future operating, financial or business performance or AC Immune’s strategies or expectations. In some cases, you can identify these statements by forward-looking words such as “may,” “might,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “projects,” “potential,” “outlook” or “continue,” and other comparable terminology. Forward-looking statements are based on management’s current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include those described under the captions “Item 3. Key Information – Risk Factors” and “Item 5. Operating and Financial Review and Prospects” in AC Immune’s Annual Report on Form 20-F and other filings with the Securities and Exchange Commission. These include: the impact of Covid-19 on our business, suppliers, patients and employees and any other impact of Covid-19. Forward-looking statements speak only as of the date they are made, and AC Immune does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law. All forward-looking statements are qualified in their entirety by this cautionary statement.